Structural chromosomal abnormalities in couples in cases of recurrent spontaneous abortions in Jilin Province, China
Authors: H.-T. Fan, M. Zhang, P. Zhan, X. Yang, W.-J. Tian and R.-W. Li
Recurrent spontaneous abortions (RSAs) occur in approximately 15 to 20% of all clinically recognizable pregnancies. Structural chromosome abnormalities result in increased risk of pregnancy loss. Parental chromosomal abnormalities are an important genetic cause of RSAs. Some cytogenetic investigations have been performed in various countries and regions t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017443
- DOI:
- 10.4238/gmr.15017443
Association of interleukin-1?² -511C/T promoter polymorphism with COPD risk: a meta-analysis
Authors: Y.S. Wang, L. Liu, X.Y. Xu, J.L. Wang, H. Zhou, T.L. Li and Z.A. Liang
Studies examining the role of interleukin (IL)-1β -511C/ T promoter polymorphism in the pathogenesis of chronic obstructive pulmonary disease (COPD) have shown inconsistent results. This metaanalysis was performed to assess the association between the IL-1β -511C/T promoter polymorphism and COPD susceptibility. Published case-control, cross-sect.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.5
- DOI:
- 10.4238/2015.May.4.5
Geographic shifts in climatically suitable areas and loss of genetic variability in Dipteryx alata (â??Baruâ? Tree; Fabaceae)
Authors: J.A.F. Diniz-Filho, R.G. Collevatti, L.J. Chaves, T.N. Soares, J.C. Nabout, T.F. Rangel, D.B. Melo, J.S. Lima and M.P.C. Telles
Many species are expected to suffer strong shifts in their geographic ranges due to climate changes in the next 50 years, with severe consequences for biodiversity patterns and population structure. We used here an ensemble forecast approach for obtaining species’ range in which multiple species distribution models and c.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.June.15.11
- DOI:
- 10.4238/2012.June.15.11
Comparative petiole anatomy of cassava (Manihot) species
Authors: D. Graciano-Ribeiro1,3, D.Y. Hashimoto-Freitas2 and N.M.A. Nassar3
In this study, we describe the petiole anatomy of six wild cassava (Manihot) species, one hybrid, and two cultivars of Manihot esculenta, in order to identify their dominant anatomical patterns and relate them to possible adaptations to abiotic factors in the Cerrado biome. The median parts of several petiole samples were transversally and longitudinally .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017495
- DOI:
- 10.4238/gmr.15017495
Expression of EpCAM and Wnt/ ?²-catenin in human colon cancer
Authors: F.Q. Zhou, Y.M. Qi, H. Xu, Q.Y. Wang, X.S. Gao and H.G. Guo
The aims of this study were to explore the correlation between the expression of EpCAM and the Wnt/β-catenin pathway in human colon cancer and its clinical significance for the evaluation of cancer prognosis. Samples from colon cancer, para-carcinoma, or benign intestinal tissue from individual patients (50) and from normal intestinal mucosal tissues.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.6
- DOI:
- 10.4238/2015.May.4.6
Analysis of prognostic factors for infantile rotavirus infection
Authors: R. Zhou, J.L. Xu, D. Wu and J.L. Tang
In this study, we investigated the prognostic factors of infantile rotavirus (RV) infection. A total of 102 infants with RV enteritis were divided into 2 groups according to the standards of improvement and cure at the time of discharge from the hospital: improvement group (N = 58; 47 males and 11 females with an average age of 15.19 ± 5.03 months).. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.3
- DOI:
- 10.4238/2015.February.2.3
Lack of association of CYP1A1-MspI SNP and GSTM1 null genotypes with cancer in a Brazilian family with unusually high cancer incidence
Authors: L.N. Moraes, M.F. Borges, P.A.C. Sousa, P.C. Venere and I.L. Souza
Research has shown that genetic polymorphisms in biotransformation enzymes, such as CYP1A1 and GSTM1, are related to a greater or lesser susceptibility to various cancers. We made an analysis of CYP1A1m1 SNP and GSTM1 null genotypes in a family group (71 members) related by consanguinity who had an unusually high incidence of .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.June.15.10
- DOI:
- 10.4238/2012.June.15.10
?²-asarone from Acorus gramineus alleviates depression by modulating MKP-1
Authors: Y.R. Sun, X.Y. Wang, S.S. Li, H.Y. Dong and X.J. Zhang
In this study, we investigated the antidepressant effects of hippocampal neuron administration of β-asarone, a selective mitogen-activated protein kinase phosphatase-1 inhibitor, in a rat model of depression. Our previous studies showed that the extracellular signal-regulated kinase signaling pathway and brain-derived neurotrophic factor expression, .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.7
- DOI:
- 10.4238/2015.May.4.7
Association between macrophage migration inhibitory factor rs1007888 and GDM
Authors: Y. Zhan, C. Li, J. Chen, S. Yu, Q. Gao, Y.P. Wang and S.G. Liu
We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study. Differences in the MIF rs1007888 genot.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.4
- DOI:
- 10.4238/2015.February.2.4
A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese
Authors: L.Q. Shen, Y.Z. Xie, X.F. Qian, Z.X. Zhuang, Y. Jiao and X.F. Qi
Lung cancer is a complex polygenic disease and many genetic factors are involved in the development of the disease. As one of the most important and widely studied families of microRNA, let- 7 appears to play an important role in initiation and progression of lung cancer. Any small changes in miRNA level or its target point can cause significant changes i.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.8
- DOI:
- 10.4238/2015.May.4.8