Inbreeding depression in single, three way and double-cross hybrids of maize
Authors: F.B.S. Botelho, A.T. Bruzi, I.P. Lima, C.S. Rodrigues and R.T. de C. Botelho
Currently, one of the acclaimed alternatives for increasing maize yield is accomplished through utilization of heterosis in hybrid cultivars. However, upon performing crosses between related pairs, there are losses due to inbreeding depression. Thus, the aim of this study was to estimate inbreeding depression and the contribution of loci in heterozygosity.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15035497
- DOI:
- 10.4238/gmr.15035497
Identification of significant pathway cross-talk in rheumatoid arthritis by the Monte Carlo cross-validation method
Authors: W. Song, Y.M. Zhang, T. Ma, J. Wang and K.Z. Wang
We attempted to identify significant pathway cross-talk in rheumatoid arthritis (RA) by the Monte Carlo cross-validation (MCCV) method. We therefore obtained and preprocessed the gene expression profile of RA. MCCV involves identifying differentially expressed genes (DEGs), identifying differential pathways (DPs), calculating .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029142
- DOI:
- 10.4238/gmr16029142
Correlation of acetabular chondrocyte apoptosis with caspase-3 and Bcl-2 expression in developmental dislocations of the hip
Authors: L.J. Ding, Y.L. Liu, G. Ma, Y.Q. Jia, Y.S.H. Wei and X.M. Liu
This study aimed to determine whether abnormal apoptosis is present in acetabular cartilage in early developmental dislocations of the hip (DDH), and if so, whether it is correlated with the expression of caspase-3 and Bcl-2. DDH was induced in 24 4-week-old New Zealand white rabbits. Acetabular cartilage specimens from the experimental and control groups.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15036809
- DOI:
- 10.4238/gmr.15036809
A novel stop codon mutation in exon 1 (558C>A) of the UGT1A1 gene in a Thai neonate with Crigler-Najjar syndrome type I
Authors: N. Wanlapakorn, P. Nilyanimit, T. Vorawandthanachai, T. Deesudjit, N. Dumrongpisutikul and Y. Poovorawan
Human uridine 5'-diphosphate-glucuronosyltransferases play a critical role in detoxification by conjugating bilirubin with glucoronic acid. Impaired or reduced enzymatic activity causes a spectrum of clinical disorders such as Crigler-Najjar syndrome type I (CN1), Crigler-Najjar syndrome type II, and GilbertâÃ?Â?Ã?Â?s syndrome. CN1 is a severe form .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.15
- DOI:
- 10.4238/2015.January.23.15
Genomic characterization and phylogenetic analysis of Chinese sacbrood virus isolated from Loess Plateau, China
Authors: H. Yu, T.X. Liu and D. Wang
The complete genomic RNA of the Chinese sacbrood virus (CSBV) strain, which infects the honeybees in the Loess plateau, was sequenced and analyzed. The CSBV-SX strain contains 8705 nucleotides, which includes a single large open reading frame (99-8681 nucleotides) encoding 2860 amino acids. A novel efficient identification method was used to investigate t.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15036928
- DOI:
- 10.4238/gmr.15036928
A novel 3-base pair deletion of the CRYAA gene identified in a large Chinese pedigree featuring autosomal dominant congenital perinuclear cataract
Authors: X.D. Kong, N. Liu, H.R. Shi, J.M. Dong, Z.H. Zhao, J. Liu,J. Li-Ling and Y.X. Yang
Congenital cataract is caused by reduced transparency of the lens resulting from metabolic disorders during the fetal period. The disease shows great heterogeneity both clinically and genetically. We identified a 4-generation ethnic Han Chinese family affected by autosomal dominant congenital perinuclear cataract. The patients underwent full clinical and .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.16
- DOI:
- 10.4238/2015.January.23.16
Role of GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms in the response to chemotherapy and overall survival of advanced non-small cell lung cancer
Authors: W. Jia, J.Y. Sun, K.Y. Jia and X.C. Liu
We evaluated the association between GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms and treatment outcomes of advanced non-small cell lung carcinoma. Between January 2010 and December 2012, a total of 244 patients with non-small cell lung carcinoma were recruited from Yiwu Central Hospital. The GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms we.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037668
- DOI:
- 10.4238/gmr.15037668
Genetic diversity of Lippia sidoides Cham. and L. gracilis Schauer germplasm
Authors: C.P. Santos, J.B. Pinheiro, M.I. Zucchi, M.M. Bajay, J.B. Campos, M.F. Arrigoni-Blank, J.A.O. Pinto and A.F. Blank
The conservation of plants in germplasm banks ensures the characterization and availability of these resources for future generations. The present study used DNA markers to obtain genetic information about germplasm collections of Lippia sidoides and L. gracilis, which are maintained in an Active Germplasm Bank (AGB). Genetic variability of samples in the.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037781
- DOI:
- 10.4238/gmr.15037781
Novel NPHS1 splice site mutations in a Chinese child with congenital nephrotic syndrome
Authors: R. Fu, M.F. Gou, W.H. Ma, J.J. He, Y. Luan and J. Liu
Congenital nephrotic syndrome (CNS) is defined as heavy proteinuria or nephrotic syndrome occurring before 3 months of age. It is characterized by early onset and progresses to end-stage renal disease. Recently, several genes associated with CNS have been identified, including NPHS1 and NPHS2. Mutations in the NPHS1 gene have been identified in patients w.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.17
- DOI:
- 10.4238/2015.January.23.17
Activin A is associated with asthma in underweight and overweight patients
Authors: L.L. Zhang and C.T. Liu
There are limited data regarding the effects of activin A on underweight, normal weight, and overweight patients with asthma. We determined serum levels of activin A in asthmatic patients in relation to body mass index. The study protocol included questionnaires, measurement of exhaled nitric oxide, blood sampling for inflammatory biomarkers, and high-res.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.18
- DOI:
- 10.4238/2015.January.23.18