Cardiac damage and dysfunction in diabetic cardiomyopathy are ameliorated by Grx1
Authors: X. Qi, A. Xu, Y. Gao, Y. Shi, X. Sun, J. Xu, J. Liu, Q. Lan, L. Chang, C. Zhang and H. Yu
Glutaredoxin 1 (Grx1) has been found to be an important endogenous antioxidant enzyme closely related to the pathogenesis of diabetes and cardiovascular diseases caused by oxidative stress. In this study, the functional changes of the Grx1 redox system in blood of hyperglycemic patients were examined. Furthermore, using a rat model of streptozotocin (STZ).. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039000
- DOI:
- 10.4238/gmr.15039000
Association of polymorphism in ICAM-1 (K469E) and cytology parameters in patients� initial blood test with acute ischemic stroke
Authors: D. Wang, F.H. Zhang,Y.T. Zhao, X.G. Xiao,S. Liu, H.B. Shi, A.L. Lin, Y.J. Wang, Q. Han, Q.M. Sun
Acute ischemic stroke (AIS) has become a serious health problem in many countries because of its poor outcome and worsening epidemic trend. Early identification of genetic risk factors and physiological indicators for stroke occurrence may help to reduce the incidence of stroke. Therefore, we conducted a case-control study inc.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.2
- DOI:
- 10.4238/2015.December.1.2
Expression of the ROR�± gene in Inner Mongolian cashmere goat hair follicles
Authors: Y.H. Zhao, Z.H. Liu, L. Wang, H.M. Xiao, C.G. Du, Y.J. Zhang,R. Su and J.Q. Li
The expression of retinoid-acid-related orphan receptor Ã?± (RORÃ?±) was evaluated at the mRNA level using real-time polymerase chain reaction (qRT-PCR), and its expression localization was determined by in situ hybridization of adult Inner Mongolian cashmere goats at different times of the year. In situ hybridization demonstrated that RORÃ?±was expressed.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.11
- DOI:
- 10.4238/2015.January.23.11
Molecular characterization, tissue expression, and polymorphism analysis of liver-type fatty acid binding protein in Landes geese
Authors: Z. Song, D. Shao, X.X. Sun, J.W. Niu and D.Q. Gong
Liver weight is an important economic trait in the fatty goose liver industry. Liver-type fatty acid binding protein (L-FABP) is involved in the formation and metabolism of fatty acids. Thus, we hypothesized that sequence polymorphisms in L-FABP were associated with fatty liver weight in goose. We first isolated, sequenced, and characterized the goose L-F.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.12
- DOI:
- 10.4238/2015.January.23.12
JNK pathway and relative transcriptional factor were involved in ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells
Authors: X. Liu, Y. Sun, L. Yue, S. Li, X. Qi, H. Zhao, Y. Yang, C. Zhang and H. Yu
Ginsenoside Rh2 has been shown to have an anti-tumor effect on a wide range of cancers. A previous study has shown that ginsenoside Rh2 can inhibit the proliferation of the human lung adenocarcinoma A549 cell line in a dose-dependent manner byactivating caspase-8/3 activity to promote apoptosis. However, the association of the JNK signaling pathways and t.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039003
- DOI:
- 10.4238/gmr.15039003
Analysis of allopolyploidy-induced rapid genetic and epigenetic changes and their relationship in wheat
Authors: T. Qiu, Y.Z. Dong, X.M. Yu, N. Zhao and Y.F. Yang
We used the conventional and methylation-sensitive randomly amplified polymorphic DNA (RAPD) and inter-simple sequence repeat (ISSR) analyses to assess genome-wide changes and explore the relationships between genetic and epigenetic variations among individuals of a newly synthesized allohexaploid wheat line whose genomic cons.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029303
- DOI:
- 10.4238/gmr16029303
Comparison of DNA extraction methods for polymerase chain reaction amplification of guanaco (Lama guanicoe) fecal DNA samples
Authors: M.I. Espinosa, A. Bertin, F.A. Squeo, A. Cort�©s and N. Gouin
Feces-based population genetic studies have become increasingly popular. However, polymerase chain reaction (PCR) amplification rates from fecal material vary depending on the species, populations, loci, and extraction protocols. Here, we assessed the PCR amplification success of three microsatellite markers and a segment of the mitochondrial control regi.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.13
- DOI:
- 10.4238/2015.January.23.13
In vitro inhibition of invasion and metastasis in colon cancer cells by TanIIA
Authors: R.W. Zhang, Z.G. Liu, Y. Xie, L.X. Wang, M.C. Li and X. Sun
The purpose of this study was to investigate the effect of the traditional Chinese medicine TanIIA on the viability, invasion, and metastasis of SW480 cells. SW480 cells were treated with TanIIA for 24 h, and MTT assays were performed to determine the effect of TanIIA on cell viability. Transwell transmembrane experiments were applied to test the effect o.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039008
- DOI:
- 10.4238/gmr.15039008
Association between interleukin-4 polymorphisms and risk of pre-eclampsia in a population of Chinese pregnant women
Authors: J. Chen, M. Zhong and Y.H. Yu
Preeclampsia is a common disease unique to pregnant women, and its development involves many genetics l factors. IL-4 is an important regulatory factor of the Th2 cellular immune response, and plays an important role in the induction of placental growth. In this study, we investigated the relationship between IL-4 C-590T, C+33.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029218
- DOI:
- 10.4238/gmr16029218
Polymorphism analysis of the intron one of insulin-like growth factor 2 receptor gene (IGF2R) in FFRC strain common carp (Cyprinus carpio L.) and its relationship with growth performance
Authors: Z.J. Dong, S.Y. Su, W.B. Zhu, C.F. Zhang, M. Ding, W.X. Chen, X.H. Yuan and Z. Xie
The insulin-like growth factor 2 receptor gene (IGF2R) encodes a transmembrane protein receptor and acts to sequester and degrade excess circulating insulin-like growth factor 2, which is critical for normal mammalian growth and development. Thus, IGF2R may serve as a candidate gene underlying growth trait in the common carp. In this study, we isolated th.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.14
- DOI:
- 10.4238/2015.January.23.14