Effect of pregnancy on the proliferation of rat adipose-derived stem cells
Authors: J.N. Li, Y. Zhang, Y.F. Wang and J.Y. Chen
Stem cell therapy faces many problems including poor survival rates and low viability. Enhancing the biological functions of stem cells improves efficacy of therapies. Estrogen, whose levels are elevated during pregnancy, affects the properties of bone marrow mesenchymal stem cells. Evidence suggests that adipose-derived stem .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019059
- DOI:
- 10.4238/gmr16019059
Association of single nucleotide polymorphisms with carcass traits in Nellore cattle
Authors: J.B.S. Ferraz, L.F.B. Pinto, F.V. Meirelles, J.P. Eler, F.M. de Rezende, E.C.M. Oliveira, H.B. Almeida, B. Woodward4 and D. Nkrumah
The association between two single nucleotide polymorphisms (SNPs), T945M and UCP1SNP1, with hot carcass weight (HCW, kg, N = 618), longissimus dorsi muscle area (REA, cm2, N = 633), and backfat thickness (BF, mm, N = 625), measured in Nellore cattle in Brazil, was evaluated. Likelihood ratio tests were used to evaluate reduce.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr650
- DOI:
- 10.4238/vol8-4gmr650
GRK2 desensitizes flow-induced responses in osteoblasts
Authors: Y. Xing, Y. Gu, X. Shan, L. Wang and J. You
Bone desensitization after mechanical loading is essential for bone to adapt to its mechanical environment. However, the desensitization mechanism is unknown. Previous studies suggest that G protein-coupled receptors (GPCRs), including P2Y and parathyroid hormone receptors, play important roles in osteoblast mechanobiology. Th.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019363
- DOI:
- 10.4238/gmr16019363
Changes of peripheral-type benzodiazepine receptors in the penumbra area after cerebral ischemia-reperfusion injury and effects of astragaloside IV on rats
Authors: Y.L. Cao, C.F. Chen, A.W. Wang, Y.B. Feng, H.X. Cheng,W.W. Zhang4and W. Xin
This study investigated the changes in peripheral benzodiazepine receptors (PBRs) in the penumbra after cerebral ischemia-reperfusion injury, and examined the effects of astragaloside IV (AST) on PBRs in rats. Sixty Sprague-Dawley rats were divided into a sham operation group, a model group, and three AST treatment groups. Cerebral ischemic models were in.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.1
- DOI:
- 10.4238/2015.January.23.1
Long non-coding RNA ENST00000457645 reverses cisplatin resistance in CP70 ovarian cancer cells
Authors: H. Yan, J.Y. Xia and F.Z. Feng
The objective of this study was to investigate the effect of downregulating long non-coding RNAs (lncRNAs) on the reversal of cisplatin resistance in CP70 ovarian cancer cells, and to identify the underlying mechanism(s) of action. An lncRNA microarray was performed to screen for downregulated lncRNAs in cisplatin-resistant CP.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019411
- DOI:
- 10.4238/gmr16019411
Genetic association between the HLA-G 14-bp insertion/deletion polymorphism and the recurrent spontaneous abortions in Saudi Arabian women
Authors: S.Y. Al Omar, L. Mansour, A.F. Alkhuriji, S. Alwasel and S. Al-Qahtani
The non-classical class I human leukocyte antigen (HLA)-G molecule was found to be predominately expressed in the extravillous cytotrophoblasts at the fetal-maternal interface during pregnancy. This molecule is critically important for successful implantation during human pregnancy. The polymorphic insertion-deletion (indel) 14-base pair (bp) site localiz.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.2
- DOI:
- 10.4238/2015.January.23.2
miR-187 induces apoptosis of SiHa cervical carcinoma cells by downregulating Bcl-2
Authors: C.Y. He and J. Yang
Cervical carcinoma is a life-threatening illness posing considerable danger to women’s health. microRNAs (miRNAs) have been shown to regulate multiple cellular events, including growth and proliferation, and miR-187 is thought to regulate the growth and apoptosis of certain cell types. Our study focused on the influence .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018969
- DOI:
- 10.4238/gmr16018969
Genetic diversity analysis of Croton antisyphiliticus Mart. using AFLP molecular markers
Authors: T.G. Oliveira1, A.M.S. Pereira2, J.S. Coppede2, S.C. Fran�§a2, L.C. Ming1 and B.W. Bertoni2
Croton antisyphiliticus Mart. is a medicinal plant native to Cerrado vegetation in Brazil, and it is popularly used to treat urogenital tract infections. The objective of the present study was to assess the genetic variability of natural C. antisyphiliticus populations using AFLP molecular markers. Accessions were collected in the states of Minas Gerais, .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017461
- DOI:
- 10.4238/gmr.15017461
Identification and association of single-nucleotide polymorphisms in gonadotropin-inhibitory hormone (GnIH) gene with egg production traits in Erlang mountainous chickens
Authors: Y.D. Hu, Q.K. Huang, Q. Zhu, D. Lan, Z.Q. Feng, L. Zhang,X. Lan, L. Ye, Y.P. Liu, M. He and H.B. Pu
Gonadotropin-inhibitory hormone (GnIH) gene is an important gene in reproduction. In this study, we screened single-nucleotide polymorphisms (SNPs) in the chicken GnIH gene among 204 individuals in Erlang mountainous chickens. We then analyzed the associations between polymorphisms of the GnIH gene and 5 egg production traits in chickens. Five SNPs (T3305C, .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.3
- DOI:
- 10.4238/2015.January.23.3
Identification of novel and useful EST-SSR markers from de novo transcriptome sequence of wheat (Triticum aestivum L.)
Authors: Z.J. Yang, Z.S. Peng and H. Yang
Simple sequence repeats (SSRs) are highly informative, polymorphic, and co-dominant Mendelian markers that provide an important genomic resource for genetic research. Recently, the use of large-scale transcriptome sequence has become a reliable and efficient approach for the identification and development of new EST-SSR markers. In this study, 8389 potent.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017509
- DOI:
- 10.4238/gmr.15017509