Expression of transforming growth factor-�²1 and connective tissue growth factor in congenital biliary atresia and neonatal hepatitis liver tissue
Authors: F.B. Li1, H. Zhao1, K.R. Peng1, Z.G. Gao2, S.J. Huang2, J.F. Tou2, X.L. Shu3and W.Z. Gu4
We investigated the expression of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) in the liver tissue of infants with congenital biliary atresia and neonatal hepatitis, as well as the relationship between the expression of the two factors and liver fibrosis. Thirty-six infants who met the cholestasis criteria we.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017217
- DOI:
- 10.4238/gmr.15017217
Genetic control and transgressive segregation of zinc, iron, potassium, phosphorus, calcium, and sodium accumulation in cowpea (Vigna unguiculata) seeds
Authors: C.A. Fernandes Santos1 and L.S. Boiteux2
Cowpea crop, through combining a range of essential minerals with high quality proteins, plays an important role in providing nutritional security to human population living in semi-arid regions. Studies on genetics of biofortification with essential minerals are still quite scarce, and the major objective of the present study was to provide genetic informat.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.16.10
- DOI:
- 10.4238/2015.January.16.10
Immunoexpression of HPV 16/18 E6 and E7 oncoproteins in high-grade cervical squamous intraepithelial lesions in HIV-positive women
Authors: L.C. Rodrigues1, N.M. de Gois Speck1, G.R. de Azevedo Focchi2, M.A. Schimidt1, R.M. Marques3 and J.C. Lascasas Ribalta1
The aim of this study was to assess the immunoexpression of human papillomavirus genotypes 16 and 18 (E6 and E7) oncoproteins in cervical high-grade squamous intraepithelial lesions (HSIL) of human immunodeficiency virus (HIV)-positive women. These results were also compared to the persistence and/or recurrence of lesions after loop electrosurgical excisi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017220
- DOI:
- 10.4238/gmr.15017220
Genetic diversity of Saccharum officinarum accessions in Pakistan as revealed by random amplified polymorphic DNA
Authors: F.A. Khan, A. Khan, F.M. Azhar and S. Rauf
Genetic diversity of 20 sugarcane accessions in Pakistan was studied using 21 random amplified polymorphic DNA markers. The mean genetic distance between the cultivars was 39.03%, demonstrating that a large part of the genome is similar among the accessions. This probably arises from a lack of parental diversity, with few clon.. Read More»
- Genet. Mol. Res. 8(4):
Genetic variability of CYP3A4 in a heterogeneous Brazilian population from Maranh�£o
Authors: S.C. Moutinho Monteiro1, I.H. de Sousa1, I.K. Pereira Belfort1,J.D. Nunes1, B.A. Sousa Penha1, M. dos Santos2, I. Drumond Louro3 and I.D.C. Guerreiro da Silva4
Inter-individual variability in drug metabolism may result in adverse drug responses. Pharmacogenetic studies have shown that polymorphisms in drug metabolizing enzymes may contribute to this variability. Among these enzymes, CYP3A4 is responsible for metabolizing over 50% of the clinically used drugs. The Brazilian population is composed of people with N.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017275
- DOI:
- 10.4238/gmr.15017275
Cloning and characterization of SPL-family genes in the peanut (Arachis hypogaea L.)
Authors: M. Li1*, S.Z. Zhao1*, C.Z. Zhao1, Y. Zhang1, H. Xia1, J. Lopez-Baltazar2, S.B. Wan1 and X.J. Wang1
SQUAMOSA promoter-binding protein-like (SPL) proteins play crucial roles in plant growth, development, and responses to environmental stressors. The peanut (Arachis hypogaea L.) is a globally important oil crop. In this study, we cloned the full-length cDNA of 15 SPLs in the peanut by transcriptome sequencing and rapid amplification of cDNA ends, and anal.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017344
- DOI:
- 10.4238/gmr.15017344
Molecular characterization of patchouli (Pogostemon spp) germplasm
Authors: S.S. Sandes1, M.I. Zucchi2, J.B. Pinheiro3, M.M. Bajay3, C.E.A. Batista3,F.A. Brito1, M.F. Arrigoni-Blank1, S.V. Alvares-Carvalho1, R. Silva-Mann1 and A.F. Blank1
atchouli [Pogostemon cablin (Blanco) Benth.] is an aromatic, herbaceous plant belonging to the Lamiaceae family native to Southeast Asia. Its leaves produce an essential oil regularly used by the perfume and cosmetics industries. However, since patchouli from the Philippines and India were described and named Pogostemon patchouli, there has been a diverge.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017458
- DOI:
- 10.4238/gmr.15017458
Protective effects of �²-carotene against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster
Authors: C.D. Dias, B.C. Ara�ºjo, E.S. Dutra and J.C. Nepomuceno
β-carotene (BC), pro-vitamin A, is an efficient antioxidant, effective in the neutralization of oxygen reactive species, which cause serious damage to DNA. Various studies have been conducted on the effectiveness of BC for chemoprevention of cancer and heart disease. Doxorubicin is a chemotherapeutic agent used for cancer.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr626
- DOI:
- 10.4238/vol8-4gmr626
Relationship between 5-HTTLPR polymorphism and post-stroke depression
Authors: W.Y. Guo1,4*, Z.H. Zhang2*, J.L. Mu3, D. Liu3, L. Zhao2, Z.Y. Yao4,5 and J.G. Song3
Post-stroke depression (PSD) is a mental illness characterized by subjective feelings of depression, cognitive dysfunction, and decreased interest. The serotoninergic system is involved in the pathogenesis of depressive disorders and is regulated by the serotonin transporter gene. The serotonin transporter-linked polymorphic region (5-HTTLPR) has been exa.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017460
- DOI:
- 10.4238/gmr.15017460
Microsatellite markers linked to the locus of the watermelon fruit stripe pattern
Authors: R.N.C.S. Gama, C.A.F. Santos, R.C.S. Dias, J.C.S.F. Alves and T.O. Nogueira
Agronomic performance and external and internal appearance of watermelon (Citrullus lanatus) fruit are important traits that should be taken into consideration during the development of a new cultivar, as well as being the principal identification elements used by the consumer, which are based on the external appearance and quality of the fruit. Externally, .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.16.11
- DOI:
- 10.4238/2015.January.16.11