Development and validation of the first SSR markers for Mimosa scabrella Benth
Authors: F.A. Saiki, A.P. Bernardi, M.S. Reis, H. Faoro, E.M. Souza, F.O. Pedrosa, A. Mantovani and A.F. Guidolin
Mimosa scabrella Benth., popularly known as ‘‘bracatinga’’, is a pioneer and endemic species of Brazil, occurring in Mixed Ombrophilous Forest associated with Brazilian Atlantic Rainforest biomes. It is a fast-growing tree of the Fabaceae family that facilitates the dynamics of ecological succession. SS.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019571
- DOI:
- 10.4238/gmr16019571
Frequency of alterations in the MEFV gene and clinical signs in familial Mediterranean fever in Central Anatolia, Turkey
Authors: G.G. Ceylan, C. Ceylan and E. Ozturk
Familial Mediterranean fever is a recessive autoinflammatory disease that is frequent in Armenians, Jews, Arabs, and Turks. The MEFV gene is responsible for this disease. We looked for MEFV gene variations (polymorphism and mutations) in a population that resides in Central Anatolia, Turkey. DNA was extracted from peripheral b.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.7.4
- DOI:
- 10.4238/2012.May.7.4
Expression of macrophage migration-inhibitory factor in duodenal ulcer and its relation to Helicobacter pylori infection
Authors: X.H. Yu, Q. Zhang, X.P. Yang, W. Yang, F. Dai, Z. Qian, Z.L. Wang, C.F. Wu, H.Z. Zhao and G.H. Wang
The aim of this study was to examine the expression of macrophage migration-inhibitory factor (MIF) in duodenal ulcer epithelial cells and its relation to Helicobacter pylori (Hp) infection, and to discuss the pathogenic roles of MIF expression and Hp infection in duodenal ulcer. MIF protein and mRNA expression was examined in samples from patients with d.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.6
- DOI:
- 10.4238/2015.October.29.6
Chloroplast diversity of Casearia grandiflora in the Cerrado of Piau� State
Authors: M.F. Costa, A.A. Pereira, J.B. Pinheiro, M.I. Zucchi, A.S.F. Ara�ºjo, R.L.F. Gomes, S.E.S. Valente, M.E.A. Oliveira and A.C.A. Lopes
Casearia grandiflora (Salicaceae) is a typical Cerrado species adapted to disturbed environments, making it useful for restoration projects. Knowledge of genetic diversity is important for establishing conservation strategies for this species. This study aimed to compare chloroplast haplotype diversity and structure of C. gran.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019572
- DOI:
- 10.4238/gmr16019572
Differential expression of hENT1 and hENT2 in colon cancer cell lines
Authors: Y. Liu, T. Zuo, X. Zhu, N. Ahuja and T. Fu
Human equilibrative nucleoside transporters (hENT) 1 and 2, encoded by SLC29A1 and SLC29A2, permit the bidirectional passage of nucleoside analogues into cells and may correlate with clinical responses to chemotherapy in patients with colorectal cancer (CRC). The purpose of this study was to evaluate the expression profiles of.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019549
- DOI:
- 10.4238/gmr16019549
Polyandrous behavior in an overexploited giant South American turtle (Podocnemis expansa) population in Central Amazon, Brazil
Authors: C. Fantin, J. Morais, R. Botero-Arias, C. Ara�ºjo, C. Camillo and I.P. Farias
The aim of the present study was to investigate the reproductive behavior of the giant Amazon River turtle (Podocnemis expansa) in the Amazon. This was carried out by estimating the degree of polymorphism in five DNA microsatellites in a sample of 359 hatchlings from 12 nests in the Mamirauá Sustainable Development Rese.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019537
- DOI:
- 10.4238/gmr16019537
Dysregulation of gene expression in a patient with depressive disorder after transient ischemic attack confirmed by a neurophysiological neuromarker
Authors: M. Trystu��a, M. �»ychowska, M. Wilk-Fra��czuk, J.D. Kropotov and M. P��chalska
The aim of this study was to evaluate dysregulation of gene expression associated with the cellular stress response in a patient with a post-“warning stroke” depressive disorder confirmed by the presence of a neurophysiological neuromarker through the use of quantitative EEG and event-related potentials. The patien.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019532
- DOI:
- 10.4238/gmr16019532
Effects and mechanism of lipoic acid on beta-amyloid-intoxicated C6 glioma cells
Authors: Z.G. Xing, G.D. Yu, L. Qin, F. Jiang and W.H. Zhao
β-amyloid peptides (Aβs) can exert neurotoxic effects through induction of oxidative damage, whereas lipoic acid (LA), a powerful antioxidant, can alleviate oxidative damage. In this study, we explored the effect and mechanism of action of LA on beta-amyloid-intoxicated C6 glioma cells. Cells were randomly divided into three groups: control (veh.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.8
- DOI:
- 10.4238/2015.October.29.8
Lack of association of the G22A polymorphism of the ADA gene in patients with ankylosing spondylitis
Authors: U. Camargo, R.A. Toledo, J.R. Cintra, D.P.T. Nunes, R. Acayaba de Toledo, C.C. Brand�£o de Mattos and L.C. Mattos
Genes located outside the HLA region (6p21) have been considered as candidates for susceptibility to ankylosing spondylitis. We tested the hypothesis that the G22A polymorphism of the adenosine deaminase gene (ADA; 20q13.11) is associated with ankylosing spondylitis in 166 Brazilian subjects genotyped for the HLA*27 gene (47 p.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.7.3
- DOI:
- 10.4238/2012.May.7.3
5-Fluorouracil induces apoptosis of colorectal cancer cells
Authors: J.T. Zhang1, W.L. Zhou2, C. He3, T. Liu1, C.Y. Li1 and L. Wang1
5-Fluorouracil (5-FU) is widely used in chemotherapy for treatment of colorectal cancer. Leucine-rich repeat-containing G protein-coupled receptor (LGR) is known to participate in the occurrence and development of breast cancer by regulating the rebirth of tumor vessels. This study aimed to explore the proliferation and apoptosis of HCT116 colorectal canc.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017326
- DOI:
- 10.4238/gmr.15017326