Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors
Authors: Z.H. Chen, J.F. Xian and L.P. Luo
Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals’ susceptibility to cancers. We aimed to investigate the asso.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018877
- DOI:
- 10.4238/gmr16018877
Effect of ST2825 on the proliferation and apoptosis of human hepatocellular carcinoma cells
Authors: Y. Deng, J. Sun and L.D. Zhang
The purpose of this study was to investigate the effect of ST2825, an inhibitor of myeloid differentiation factor 88 (MyD88), on the proliferation and apoptosis of human hepatocellular carcinoma (HCC) cells as well as the potential mechanism and clinical significance of ST2825 in the treatment of HCC. Immunohistochemical staining with an MyD88 antibody wa.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016826
- DOI:
- 10.4238/gmr.15016826
Comparative study of 13 candidate genes applying multi-reference normalization to detect the expression of different fineness in skin tissues of wool sheep
Authors: Y.Z. Tian, T. Usman, K.C. Tian, J. Di, X.X. Huang, X.M. Xu, H. Tulafu, W.W. Wu, X.F. Fu, Y. Bai, M. Tuerxun and A. Maimaiti
Fiber diameter is a useful indicator of wool traits and it is the main determinant of wool quality and value. A comparative study was conducted to analyze the abundance and expression of 13 candidate genes using expression profile microarray analysis and to identify novel molecular markers associated with wool traits to provid.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018905
- DOI:
- 10.4238/gmr16018905
Polymorphic microsatellite loci for Japanese Spanish mackerel (Scomberomorus niphonius)
Authors: L. Lin, L. Zhu, S.-F. Liu, Q.-S. Tang, Y.-Q. Su and Z.-M. Zhuang
We isolated and characterized 21 polymorphic microsatellite loci in Japanese Spanish mackerel (Scomberomorus niphonius) using a (GT)13-enriched genomic library. Forty individuals were collected from Qingdao, China. We found 3 to 24 alleles per locus, with a mean of 8.8. The observed and expected heterozygosities ranged from 0... Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.8.2
- DOI:
- 10.4238/2012.May.8.2
TGF-�²1 and Serpine 1 expression changes in traumatic deep vein thrombosis
Authors: J.W. Mo, D.F. Zhang, G.L. Ji, X.Z. Liu and B. Fan
The objective of this study was to investigate the expression changes of transforming growth factor β1 (TGF-β1) and Serpine 1 in rats with traumatic deep vein thrombosis (DVT). In total, 60 male Sprague Dawley rats were divided into model (N = 50) and control groups (Group A, N = 10). From the model group, 10 rats were randomly selected after mo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.3
- DOI:
- 10.4238/2015.October.29.3
Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population
Authors: J.D. Sun, H. Yuan, H.Q. Hu and H.M. Yu
We investigated the possible correlations between N-acetyltransferase-2 (NAT2) gene polymorphisms and the risk of coronary heart disease (CHD). CHD patients (113) and healthy controls (118) were enrolled from the First People’s Hospital of Yuhang between January 2013 and June 2014. The patients were divided into mild CHD (N = 72) and severe CHD (N =.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016954
- DOI:
- 10.4238/gmr.15016954
Identification and cloning of GOLDEN2-LIKE1 (GLK1), a transcription factor associated with chloroplast development in Brassica napus L.
Authors: Y.L. Pan, Y. Pan, C.M. Qu, C.G. Su, J.H. Li and X.G. Zhang
Photosynthesis is the process by which dry matter accumulates, which affects rapeseed yield. In this study, we identified GOLDEN2-LIKE1 (GLK1), located on chromosome A07 and 59.2 kb away from the single nucleotide polymorphism marker SNP16353A07, which encodes a transcription factor associated with the rate of photosynthesis i.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018942
- DOI:
- 10.4238/gmr16018942
Genotypic and allelic frequencies of gene polymorphisms associated with meat tenderness in Nellore beef cattle
Authors: M.E. Carvalho, J.P. Eler, M.N. Bonin, F.M. Rezende, F.H. Biase, F.V. Meirelles, L.C.A. Regitano, L.L. Coutinho, J.C.C. Balieiro and J.B.S. Ferraz
The objectives of this study were to characterize the allelic and genotypic frequencies of polymorphisms in the µ-calpain and calpastatin genes, and to assess their association with meat tenderness and animal growth in Nellore cattle. We evaluated 605 Nellore animals at 24 months of age, on average, at slaughter. The pol.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018957
- DOI:
- 10.4238/gmr16018957
Use of simple sequence repeat markers for DNA fingerprinting and diversity analysis of sugarcane (Saccharum spp) cultivars resistant and susceptible to red rot
Authors: U. Hameed, Y.-B. Pan, K. Muhammad, S. Afghan and J. Iqbal
Red rod is an economically important disease of sugarcane caused by the fungus Colletotrichum falcatum. We used a simple sequence repeat (SSR)-based marker system to identify and analyze genetic relationships of red rot resistant and susceptible sugarcane cultivars grown in Pakistan. Twenty-one highly polymorphic SSR markers w.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.8.1
- DOI:
- 10.4238/2012.May.8.1
Effect of high-intensity exercise on interleukin-15 expression in rabbit synovia
Authors: Y.H. Wang, X.D. Li, W.B. Zhu and G.F. Sun
The objective of this study was to examine the effect of high-intensity exercise on interleukin-15 (IL-15) expression in rabbit synovia. We utilized 24 New Zealand white rabbits, which were randomly divided equally into high-intensity exercise and control groups. The former were forced to run for 60 min/day over 4 weeks at the speed of 30 m/min. The histo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.5
- DOI:
- 10.4238/2015.October.29.5