Association analysis of rs2275913G>A and rs763780T>C interleukin 17 polymorphisms in Chinese women with cervical cancer
Authors: L.X. Sun, X.B. Wang and X.J. Huang
We conducted a case-control study with a relatively large sample size, and investigated the association between rs2275913G>A and rs763780T>C and the risk of cervical cancer. Three hundred and six newly diagnosed patients with histologically confirmed cervical cancer and 354 cancer-free control subjects were recruited from the Forestry General Hospit.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.22
- DOI:
- 10.4238/2015.October.28.22
5-Aza-2�-deoxycytidine may influence the proliferation and apoptosis of cervical cancer cells via demethylation in a dose- and time-dependent manner
Authors: T.T. Yao S.M. Mo L.Y. Liu H.W. Lu M.L. Huang Z.Q. Lin
The methylation of tumor suppressor genes has been shown to be involved in many human cancers. 5-Aza-2’-deoxycytidine (5-Aza-CdR) can reactivate the expression of methylated tumor suppressor genes. In our study, 2 human cervical cancer cell lines, HeLa and SiHa, were treated with different concentrations (20, 10, 5, and 2.5 μM) of 5-Aza-CdR for 2.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.4.5
- DOI:
- 10.4238/2013.February.4.5
Validation of EST-derived microsatellite markers for two Cerrado-endemic Campomanesia (Myrtaceae) species
Authors: E.A.G.C. Miranda1, C.R.D. Boaventura-Novaes2, R.S. Braga1, E.F. Reis3,J.F.N. Pinto3 and M.P.C. Telles1
We assessed the transferability of 120 EST-derived Eucalyptus microsatellite primers to Campomanesia adamantium and C. pubescens. Both species are berry trees native to the Brazilian Cerrado, and population genetic information is poor. Twelve markers were used to analyze the genetic variability of four sampled populations. Regarding DNA extraction, we sam.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017658
- DOI:
- 10.4238/gmr.15017658
Gene silencing during development ofin vitro-produced female bovine embryos
Authors: G.K.F. Merighe, F.H. Biase, W.K.F. Santos-Biase, M.S. Miranda,T.H.C. de Bem, Y.F. Watanabe and F.V. Meirelles
In early development, female embryos (XX) produce twice the transcripts of X-linked genes compared with male embryos (XY). During the course of development, inactivation of the X chromosome equilibrates gene dosage, making the development of female embryos viable. Moreover, the biotechnologies used for producing embr.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr638
- DOI:
- 10.4238/vol8-3gmr638
Somatic copy-neutral loss of heterozygosity and copy number abnormalities in Malaysian sporadic colorectal carcinoma patients
Authors: Y.Y. Yam B.P. Hoh N.H. Othman S. Hassan M.M. Yahya Z. Zakaria R. Ankathil
Colorectal cancer is one of the most common cancers in many countries, including Malaysia. The accumulation of genomic alterations is an important feature of colorectal carcinogenesis. A better understanding of the molecular events underlying the stages of colorectal carcinogenesis might be helpful in the detection and management of the disease. We used a.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.7.1
- DOI:
- 10.4238/2013.February.7.1
RAPD-based study of genetic variation and relationships among wild fig genotypes in Turkey
Authors: M. Akbulut, S. Ercisli and H. Karlidag
The fig tree (Ficus carica L.) is of significant socio-economic importance in Turkey, with 25% of the world’s fig production. Genetic variation and relationships among 14 wild-grown figs sampled from Coruh Valley in Turkey were characterized by random amplified polymorphic DNA (RAPD). Ninety-eight DNA fragments were scor.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr634
- DOI:
- 10.4238/vol8-3gmr634
rs3918242 MMP9 gene polymorphism is associated with myocardial infarction in Mexican patients
Authors: J.M. RodrÃ?Âguez-PÃ?©rez1*, G. Vargas-AlarcÃ?³n1*, R. Posadas-SÃ?¡nchez2,T.X. Zagal-JimÃ?©nez1, R. OrtÃ?Âz-AlarcÃ?³n1, B. Valente-Acosta1, C. Tovilla-ZÃ?¡rate3, C. Nostroza-HernÃ?¡ndez1, O. PÃ?©rez-MÃ?©ndez1 and N. PÃ?©rez-HernÃ?¡ndez1,4
Several studies have demonstrated that matrix metalloproteinases (MMPs) play a major role in atherosclerotic plaque disruption and lead to myocardial infarction (MI). We investigated the association between the MMP1 -1607 1G/2G (rs1799750), MMP3 -1612 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms and the risk of developing MI in a Mexica.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017776
- DOI:
- 10.4238/gmr.15017776
Effects of exogenous protease supplementation on endogenous trypsin activity and gene expression in broilers
Authors: L. Yuan, S.Q. Wang, Z.X. Wang, H. Zhu and K. Huang
Two hundred and forty one-day-old male broiler chickens (Ross-308) were fed corn-soybean basal diets with 0, 40, 80, or 160 mg/kg of an acid protease preparation from 1 to 42 days of age, in order to investigate the effects of an exogenous enzyme on growth performance, pancreatic trypsin activity and mRNA expression. Average daily gain (ADG) was greatest .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.25
- DOI:
- 10.4238/2015.October.28.25
SRAP analysis of genetic diversity of nine native populations of wild sugarcane, Saccharum spontaneum, from Sichuan, China
Authors: D. Chang, F.Y. Yang, J.J. Yan, Y.Q. Wu, S.Q. Bai, X.Z. Liang, Y.W. Zhang and Y.M. Gan
Saccharum spontaneum is a wild sugarcane species that is native to and widely distributed in China. It has been extensively used in sugarcane breeding programs, and is being tested for the development of bioenergy cultivars. In order to provide basic information for the exploitation of this species, we analyzed genetic variati.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.9.3
- DOI:
- 10.4238/2012.May.9.3
Assessment of the mutagenic, genotoxic and cytotoxic potential of the waters of the Preto River in the area influenced by S�£o Jos�© do Rio Preto, SP
Authors: L.R. Maschio
-.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3ta020
- DOI:
- 10.4238/vol8-3ta020