Anti-inflammatory effects of essential oils from Mangifera indica
Authors: R.M. Oliveira, T.S. Dutra, E. Simionatto, N. R�©, C.A.L. Kassuya, C.A.L. Cardoso
Mangifera indica is widely found in Brazil, and its leaves are used as an anti-inflammatory agent in folk medicine. The aim of this study is to perform composition analysis of essential oils from the M. indica varieties, espada (EOMIL1) and coração de boi (EOMIL2), and confirm their anti-inflammatory properties. .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019227
- DOI:
- 10.4238/gmr16019227
Paracrine effect of bone marrow mesenchymal stem cells on proliferation, apoptosis, and alpha-actin-2 expression in hepatic stellate cells
Authors: H.-J. Cao, M.-D. Wang, S.-G. Li, L. Zhu, J.-H. Zheng
We investigated the paracrine effects of bone marrow mesenchymal stem cells (BMSCs) on the proliferation, apoptosis, and alpha-actin-2 (ACTA2) expression of hepatic stellate cells (HSCs), and explored the possible mechanisms of hepatocyte growth factor (HGF). We established a co-culture system by culturing BMSCs on the upper layer and HSCs on the lower la.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019201
- DOI:
- 10.4238/gmr16019201
Genetic relationships among five varieties of Curcuma alismatifolia (Zingiberaceae) based on ISSR markers
Authors: S. Taheri T.L. Abdullah N.A.P. Abdullah Z. Ahmad
The genus Curcuma is a member of the ginger family (Zingiberaceae) that has recently become popular for use as flowering pot plants, both indoors and as patio and landscape plants. We used PCR-based molecular markers (ISSRs) to assess genetic variation and relationships between five varieties of curcuma (Curcuma alismatifolia) cultivated in Malaysia. Sixteen.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.4
- DOI:
- 10.4238/2012.August.31.4
Multivariate diallel analysis allows multiple gains in segregating populations for agronomic traits in Jatropha.
Authors: P.E. Teodoro, E.V. Rodrigues, L.A. Peixoto, L.A. Silva, B.G. Laviola, L.L. Bhering
Jatropha is research target worldwide aimed at large-scale oil production for biodiesel and bio-kerosene. Its production potential is among 1200 and 1500 kg/ha of oil after the 4th year. This study aimed to estimate combining ability of Jatropha genotypes by multivariate diallel analysis to select parents and crosses that allo.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019545
- DOI:
- 10.4238/gmr16019545
Expression profiling based on coexpressed modules in obese prepubertal children
Authors: J.F. Zhang G.Y. Yao Y.H. Wu
The aim of this study was to identify related genes and the underlying molecular mechanisms in obese patients who show a series of clinical and metabolic abnormalities known as metabolic syndrome. We identified expression profiles through a coexpression network. In addition, a similarity matrix and expression modules were constructed based on domain and p.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.5
- DOI:
- 10.4238/2012.August.31.5
Molecular phylogenetic study of Cardamine amaraeformis Nakai using nuclear and chloroplast DNA markers
Authors: M.A. Ali J. Lee S.Y. Kim F.M.A. Al-Hemaid
The internal transcribed spacer regions of nuclear ribosomal DNA, trnL and trnL-F chloroplast genes of Cardamine amaraeformis Nakai (Brassicaceae) were sequenced and analyzed with the sequences of related Cardamine sp available in GenBank to detect the pattern of C. amaraeformis evolutionary differentiation. C. amaraeformis, which is endemic to South Korea, .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.6
- DOI:
- 10.4238/2012.August.31.6
Construction of the intermediate vector pVBG2307 by incorporating vital elements of expression vectors pBI121 and pBI221
Authors: S.S. Ahmed Z.-H. Gong J.-J. Ji Y.-X. Yin H.-J. Xiao M.A. Khan A. Rehman I. Ahmad
Molecular chaperones of plasmid pBI121 carrying CaMV35S promoter and a nucleotide sequence of plasmid pBI221 were inserted into plasmid pCAMBIA2300 to construct an intermediate vector: pVBG2307. This novel vector pVBG2307 contains a greatly expanded multiple cloning site with an adjacent imported CaMV35S promoter sequence. This vector allows controlled tr.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.7
- DOI:
- 10.4238/2012.August.31.7
Recombinant adeno-associated virus BMP-4/7 fusion gene confers ossification activity in rabbit bone marrow stromal cells
Authors: S.H. Yuan C.B. Gao C.U. Yin Z.G. Yin
The biological effects of transfection of an adeno-associated virus (AAV) vector with bone morphogenetic proteins 4 and 7 (BMP-4/7) fusion gene (AAV-BMP-4/7) were determined in rabbit bone marrow stromal cells (BMSCs). BMP-4 and BMP-7 genes were obtained through one-step reverse transcriptase polymerase chain reaction from human placental cells. The BMP-4.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.8
- DOI:
- 10.4238/2012.August.31.8
Co-inheritance of variants/mutations in Malaysian patients with Crohn�s disease
Authors: K.H. Chua C.C. Ng I. Hilmi K.L. Goh
Crohn’s disease is a chronic, relapsing inflammatory bowel disease; it affects the mucosa and deeper layers of the digestive wall. Two Crohn’s disease patients who carried the JW1 variant and two patients who carried the SNP5 variant were investigated for other co-inherited polymorphisms that could influence Crohn’s disease development. .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.9
- DOI:
- 10.4238/2012.August.31.9
11�²-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease
Authors: F. Atalar B. Vural C. Ciftci A. Demirkan G. Akan B. Susleyici-Duman D. Gunay B. Akpinar E. Sagbas U. Ozbek A.S. Buyukdevrim
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) activity and mRNA levels are increased in visceral and subcutaneous adipose tissues of metabolic syndrome subjects. We analyzed 11β-HSD-1 expression in human epicardial adipose (EA) and ascending aorta (AA) tissues of metabolic syndrome patients and examined their contribution to the devel.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.10
- DOI:
- 10.4238/2012.August.31.10