Microdeletions in 16p11.2 and 13q31.3 associated with developmental delay and generalized overgrowth
Authors: A.M. George J. Taylor D.R. Love
Chromosome microarray analysis of patients with developmental delay has provided evidence of small deletions or duplications associated with this clinical phenotype. In this context, a 7.1- to 8.7-Mb interstitial deletion of chromosome 16 is well documented, but within this interval a rare 200-kb deletion has recently been defined that appears to be assoc.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.3.1
- DOI:
- 10.4238/2012.September.3.1
CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer
Authors: T.D. Silva A.V. Felipe C.A.M. Pimenta K. Bar�£o N.M. Forones
We investigated a possible association between alcoholism, cigarette smoking, obesity and CYP2E1 RsaI and 96-bp insertion genetic polymorphisms with risk for colorectal cancer (CRC). Patients with CRC (70 women and 61 men) were matched for gender and age to 206 healthy controls. The mean age of the two groups was 62 years. Meat intake, cigarette smoking a.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.3.2
- DOI:
- 10.4238/2012.September.3.2
Expression and function of PDGF-�± in columnar epithelial cells of age-related cataracts patients
Authors: J. Wei, H. Tang, Z.Q. Xu, B. Li, L.Q. Xie and G.X. Xu
We studied the expression and function of platelet-derived growth factor A (PDGF-α) in the lens epithelial cells of cataracts patients. Ninety age-related cataracts patients were recruited in our hospital between January 2012 and January 2014. The expression levels of platelet-derived growth factor receptor (PDGFR) in the anterior capsule of the len.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.28
- DOI:
- 10.4238/2015.October.26.28
Diversity among isolates of cowpea severe mosaic virus infecting cowpeas in northeastern Brazil
Authors: E.F.M. Abreu M.L.P. Tinoco E.C. Andrade F.J.L. Arag�£o
Eleven isolates of cowpea severe mosaic virus (CPSMV), a member of the genus Comovirus, were selected from 50 samples collected of nine cowpea fields in Northeastern Brazil (PiauÃ?Â, CearÃ?¡, Rio Grande do Norte, ParaÃ?Âba, Pernambuco, Alagoas, Sergipe, Bahia, and Distrito Federal) and partially sequenced. The RNA1 partial sequence, corresponding to the h.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.3.3
- DOI:
- 10.4238/2012.September.3.3
Mini tomato genotypes resistant to the silverleaf whitefly and to two-spotted spider mites
Authors: G.M. Maciel, R.S. Almeida, J.P.R. da Rocha, V. Andal�³, G.R. Marquez, N.C. Santos and R.R. Finzi
The mini tomato production has expanded, becoming an amazing alternative for enterprise. Despite all commercial potential, the cultivation has the occurrence of pests as main obstacle during the crop development. Nowadays, there are no researches that aimed obtaining genotypes with high acylsugar content, capable of providing .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019539
- DOI:
- 10.4238/gmr16019539
Mineral content is related to antioxidant and antimutagenic properties of grape juice
Authors: C. Dani L.S. Oliboni D. Pr�¡ D. Bonatto C.E.I. Santos M.L. Yoneama J.F. Dias M. Salvador J.A.P. Henriques
Grape juices are an important source of food antioxidants. Unfortunately, there is little data about the mineral composition and the antioxidant, mutagenic and antimutagenic activities of grape juice in eukaryote cells. We evaluated the mineral contents (Mg, Ca, Mn, Fe, Cu, Zn, Si, S, Cl) of grape juices, the antioxidant, mutagenic and/or antimutagenic activ.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.3.4
- DOI:
- 10.4238/2012.September.3.4
Cytotoxicity of 1-dodecyl-3-methylimidazolium bromide on HepG2 cells
Authors: T.H. Li, C.Q. Jing, K.L. Gao, W.Y. Yue and S.F. Li
We evaluated the cytotoxicity of 1-dodecyl-3-methylimidazolium bromide ([C12mim][Br]) on HepG2 cells and its influence on plasma membrane permeability. The results showed that [C12mim][Br] inhibited HepG2 cell growth and decreased cell viability in a concentration-dependent manner. The results also revealed that [C12mim][Br] exposure induced apoptosis in .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.31
- DOI:
- 10.4238/2015.October.26.31
Laronidase for treating mucopolysaccharidosis type I.
Authors: R.P. El Dib, G.M. Pastores
Mucopolysaccharidoses are a group of inherited metabolic diseases caused by the absence or deficiency of the lysosomal enzymes that are needed for breaking down glycosaminoglycans (GAGs). Over time, GAGs collect in cells, blood and connective tissues, and increased amounts are excreted in the urine. The result is permanent and.. Read More»
- Genet. Mol. Res. 6(3):
cDNA, genomic sequence cloning and overexpression of giant panda (Ailuropoda melanoleuca) mitochondrial ATP synthase ATP5G1
Authors: W.-R. Hou Y.-L. Hou X. Ding T. Wang
The ATP5G1 gene is one of the three genes that encode mitochondrial ATP synthase subunit c of the proton channel. We cloned the cDNA and determined the genomic sequence of the ATP5G1 gene from the giant panda (Ailuropoda melanoleuca) using RT-PCR technology and touchdown-PCR, respectively. The cloned cDNA fragment contains an open reading frame of 411 bp .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.3.5
- DOI:
- 10.4238/2012.September.3.5
Role of interleukin-6 gene polymorphisms in the development of prostate cancer
Authors: C.H. Chen, M. Gong, Q.T. Yi and J.H. Guo
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. A total of 212 consecutive primary prostate cancer patients and 236 control subjects were recruited between May 2012 and May 2014. The IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796) polymorp.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.34
- DOI:
- 10.4238/2015.October.26.34