Inhibition of invasion and migration of prostate cancer cells by miRNA-509-5p via targeting MDM2
Authors: X.M. Tian, Y.Z. Luo, P. He, J. Li, Z.W. Ma and Y. An
Prostate cancer is a common malignancy of the male reproductive-urinary system. MDM2 is an oncogene, whose expression can be regulated by microRNA (miRNA). The present study investigated the expression and correlation of miRNA-509-5p and MDM2 to determine the mechanism of their function in invasion and migration of prostate ca.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019195
- DOI:
- 10.4238/gmr16019195
Characterization and expression analysis of a cyclin B gene from black tiger shrimp (Penaeus monodon)
Authors: C. Zhao, M.J. Fu, F.L. Zhou, Q.B. Yang, S.G. Jiang and L.H. Qiu
The open reading frame of black tiger shrimp (Penaeus monodon) cyclin B (Pmcyclin B) was identified, based on cDNA sequence registered in GenBank (accession No. EF015590). The target sequence was 1206 bp, corresponding to 401 amino acids. Two conserved signature sequences of the cyclin B gene family were found in the Pmcyclin B deduced aa sequence. Tempor.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.36
- DOI:
- 10.4238/2015.October.26.36
A novel lumazine synthase molecule from Brucella significantly promotes the immune-stimulation effects of antigenic protein
Authors: Z.Q. Du and J.Y. Wang
Brucella, an intracellular parasite that infects some livestock and humans, can damage or destroy the reproductive system of livestock. The syndrome is referred to as brucellosis and often occurs in pastoral areas; it is contagious from livestock to humans. In this study, the intact Brucella suis outer membrane protein 31 (omp31) gene was cloned, recombin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.4
- DOI:
- 10.4238/2015.October.26.4
Effects of Cx43 gene modification on the proliferation and migration of the human lung squamous carcinoma cell line NCI-H226
Authors: J.-P. Zang and R. Wei
In this study, the human lung squamous carcinoma cell line NCI-H226 was transfected with the recombinant plasmid pBudCE4.1_Cx43 to explore the role of the Cx43 gene in cell growth, cell cycle, and tumor migration. pBudCE4.1-Cx43 was transfected into human lung squamous carcinoma NCI-H226 cells using Lipofectamine TM2000. The mRNA and protein expressions o.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.7
- DOI:
- 10.4238/2015.October.26.7
Differentiation of four strains of Chinese soft-shelled turtle (Pelodiscus sinensis) based on high-resolution melting analysis of single nucleotide polymorphism sites in mitochondrial DNA
Authors: H.Q. Zhang, C. Zhang, X.J. Xu, J.J. Zhu, Z.Y. He and J.Z. Shao
The Chinese soft-shelled turtle (Pelodiscus sinensis) has been one of the most economically important aquatic animals in China for thousands of years, and several breeding strains have been formed. Since the morphological characteristics of some strains are similar, a rapid and accurate molecular method to differentiate between strains is required. In thi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.10
- DOI:
- 10.4238/2015.October.26.10
MicroRNA expression profile of a Malaysian Bajau family with familial mitochondrial neurogastrointestinal encephalomyopathy
Authors: F.L. Yong, C.W. Wang and K.S. Tan
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare, autosomal recessive disorder associated with mutations in the thymidine phosphorylase (TYMP) gene. The main objective of this study was to characterize the genetic profiles of the deceased proband’s family members (N = 4) using DNA sequencing and to determine miRNA deregulation.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.13
- DOI:
- 10.4238/2015.October.26.13
A large-scale analysis study on the clinical and viral characteristics of hepatitis B infection with concurrence of hepatitis B surface or E antigens and their corresponding antibodies
Authors: Y. Xiang, P. Chen, J.R Xia and L.P. Zhang
Concurrent detection of hepatitis B surface antigen (HBsAg) and anti-HBs antibody or hepatitis B surface E antigen (HBeAg) and anti-HBe antibody in patients with chronic hepatitis B (CHB) infection is well established. However, the clinical implications of these proteins remain largely unknown. In this study, demographic, clin.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019102
- DOI:
- 10.4238/gmr16019102
Identification of lipopeptides produced by Bacillus subtilis Czk1 isolated from the aerial roots of rubber trees
Authors: C.P. He, L.Y. Fan, W.H. Wu, Y.Q. Liang, R. Li, W. Tang, X.L. Zheng, Y.N. Xiao, Z.X. Liu and F.C. Zheng
We obtained a strain of Bacillus subtilis, which we named Czk1, from the aerial roots of rubber trees. This bacterial isolate exhibits strong antagonistic activity against Ganoderma pseudoferreum, Phellinus noxius, Helicobasidium compactum, Rigidoporus lignosus, Sphaerostilbe repens, and Colletotrichum gloeosporioides. Our ear.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018710
- DOI:
- 10.4238/gmr16018710
Clinical significance of CD44 expression in children with hepatoblastoma
Authors: H.-Y. Cai, B. Yu, Z.-C. Feng, X. Qi and X.-J. Wei
The aim of this study was to investigate the expression of CD44 and its clinical significance in children suffering from hepatoblastoma (HB). CD44 expression was detected with immunohistochemistry staining in 30 samples from hepatoblastoma children and 10 normal liver tissue samples from normal children. The data obtained was statistically analyzed using .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.16
- DOI:
- 10.4238/2015.October.26.16
Association between IL2/IL21 and SH2B3 polymorphisms and risk of celiac disease: a meta-analysis
Authors: C.C. Guo, W.H. Huang, N. Zhang, F. Dong, L.P. Jing, Y. Liu, X.G. Ye, D. Xiao, M.L. Ou, B.H. Zhang, M. Wang, W.K. Liang, G. Yang and C.X. Jing
Celiac disease (CD) is a common autoimmune disorder characterized by heightened immunological response to ingested gluten. Certain gene polymorphisms of IL2/IL21 (rs6822844 and rs6840978) and SH2B3 (rs3184504) may influence susceptibility to CD, although the effects remain unclear. We performed a meta-analysis of the associations between rs6822844, rs6840.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.19
- DOI:
- 10.4238/2015.October.26.19