Study of the expression of GABAA receptor in rats during acute lung injury caused by endotoxin
Authors: L.Y. Zhan, L. Du, Z.Y. Xia, W.L. Li and B. Zhao
The objective of the present study was to investigate the role of γ-aminobutyric acid type A receptor (GABAAR) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats. Thirty-two male wistar rats were randomly divided into four groups. Rats in the GABA group were pretreated with LPS and GABA, while those in the bicuculline (BIC) group we.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.27
- DOI:
- 10.4238/2015.October.26.27
Cloning and transformation of INDUCER of CBF EXPRESSION1 (ICE1) in tomato
Authors: X.H. Yu, J.X. Juan, Z.L. Gao, Y. Zhang, W.Y. Li and X.M. Jiang
The tomato plant (Solanum lycopersicum Mill.) is sensitive to cold, and low field temperatures can result in shortened growth periods and decreased crop yield. Transcription of CRT/DRE-binding factor (CBF) is regulated by INDUCER of CBF EXPRESSION1 (ICE1). CBF activates many downstream genes that confer cold tolerance on plants. ICE1 has been used in gene.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.9
- DOI:
- 10.4238/2015.October.26.9
Embryogenesis in the anthers of different ornamental pepper (Capsicum annuum L.) genotypes
Authors: P.A. Barroso, M.M. R�ªgo, E.R. R�ªgo and W.S. Soares
The aim of this study was to relate flower bud size with microspore developmental stages and the induction of embryos in the anthers of different ornamental pepper (Capsicum annuum L.) genotypes. Flower buds were randomly collected and visually divided into three classes based on both petal and sepal size. The length and diameter of the bud as well as the.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.32
- DOI:
- 10.4238/2015.October.26.32
Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer
Authors: W.T. Qi, J.L. Gao and S.S. Zhang
We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were collected between May 2012 and May 2014. The SNP genotyping of IL-17A rs2275913G>A .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.33
- DOI:
- 10.4238/2015.October.26.33
Distribution of mitochondrial DNA fragments in the nuclear genome of the honeybee
Authors: W.X. Du and Y.C. Qin
Nuclear mitochondrial pseudogenes (numts), which originated from mitochondrial DNA (mtDNA) insertions in the nuclear genome, have been detected in many species. The distribution of numts in the honeybee nuclear genome has not yet been fully reported. By referring to the whole honeybee mtDNA sequence and to the recent version of the honeybee nuclear genome.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.35
- DOI:
- 10.4238/2015.October.26.35
MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell
Authors: Q.S. Anders, E. Stur, L.P. Agostini, F.M. Garcia, R.S. Reis, J.A. Santos, S.O. Mendes, L.L. Maia, G.T. Peterle, V. Stange, M.B. Carvalho, E.H. Tajara, M. Santos, A.M.A. Silva-Conforti and I.D. Louro
The C677T and A1298C polymorphisms in methylenetetrahydrofolate reductase (MTHFR), which regulates the release of active folate in the body, may have reduced activity. Given that folate participates in important intracellular pathways, such as nucleotide synthesis and biomolecule methylation, it seems plausible that patients with head and neck squamous ce.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.6
- DOI:
- 10.4238/2015.October.26.6
Multidrug resistance gene and its relationship to ulcerative colitis and immune status of ulcerative colitis
Authors: Y.J. Zhang1, J.J. Xu1, P. Wang2 and J.L. Wang1
We examined the relationship among the multidrug resistance (MDR1) gene product P-glycoprotein (P-gp), ulcerative colitis, and immune status under ulcerative colitis. MDR1 P-gp expression and interleukin-8 levels in ulcerative colitis were determined using immunohistochemistry and a double-antibody sandwich avidin-biotin complex-enzyme-linked immunosorben.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.19.5
- DOI:
- 10.4238/2014.December.19.5
Differential responses of one hundred tomato genotypes grown under cadmium stress
Authors: M.M. Hussain, A. Saeed, A.A. Khan, S. Javid and B. Fatima
Due to increased global concern over the deleterious effects of toxic heavy metals in the environment, it has become necessary to develop plant genotypes that limit the uptake of heavy metals to aerial edible parts. To address this concern, we performed a glasshouse experiment to assess variations within tomato germplasm for cadmium (Cd) tolerance under c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.12
- DOI:
- 10.4238/2015.October.26.12
A rare PAX6 mutation in a Chinese family with congenital aniridia
Authors: F. He, D.L. Liu, M.P. Chen, L. Liu, L. Lu, M. Ouyang, J. Yang, R. Gan and X.Y. Liu
Aniridia is an autosomal dominant disorder characterized by the complete or partial loss of the iris and is almost associated with mutations in the paired box gene 6 (PAX6). We examined three generations of a Chinese family with congenital aniridia and observed genetic defects. Exons of PAX6 from 12 family members were amplified by polymerase chain reacti.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.29
- DOI:
- 10.4238/2015.October.26.29
Genetic polymorphisms and retinal vein occlusion in an Italian population
Authors: L. De Polo, P.E. Maltese, E. Rigoni, M. Bertelli, S. Cecchin, G. Staurenghi and G. Stoppa
In this study, we assessed the prevalence of polymorphisms in genes involved in hyperhomocysteinemia or hemostasis to shed light on their role, if any, in retinal vein occlusion (RVO). We recruited 37 Italian patients (17 men and 20 women) with a diagnosis of central or branch RVO based on fundus examination and retinal fluorescein angiography, as well as.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.30
- DOI:
- 10.4238/2015.October.26.30