Analysis of upland cotton (Gossypium hirsutum) response to Verticillium dahliae inoculation by transcriptome sequencing
Authors: B.X. Shao, Y.L. Zhao, W. Chen, H.M. Wang, Z.J. Guo, H.Y. Gong, X.H. Sang, Y.L. Cui and C.H. Wang
Verticillium wilt is one of the main diseases in cotton (Gossypium hirsutum), severely reduces yield and fiber quality, and is difficult to be controlled effectively. At present, the molecular mechanism that confers resistance to this disease is unclear. Transcriptome sequencing is an important method to detect resistance genes, explore metabolic pathways.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.8
- DOI:
- 10.4238/2015.October.26.8
Comparison of gSSR and EST-SSR markers for analyzing genetic variability among tomato cultivars (Solanum lycopersicum L.)
Authors: R. Zhou, Z. Wu, F.L. Jiang and M. Liang
In order to study genetic variability and develop better strategies for the utilization of 48 tomato cultivars from America, China, the Netherlands, and Portugal, genomic simple sequence repeat (gSSR) and EST-derived SSR (EST-SSR) markers were applied. In all, 15 of 82 gSSR and 18 of 115 EST-SSR markers showed polymorphic loci. There were 995 and 2072 cle.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.14
- DOI:
- 10.4238/2015.October.26.14
Elevated TrkA receptor expression is associated with all-trans retinoic acid-induced neuroblastoma differentiation
Authors: Q. Gao, C.F. Chen, Q. Dong, L. Hou, X. Chen, Y.L. Zhi, X. Li, H.T. Lu and H.Y. Zhang
Neuroblastoma is the most common and one of the deadliest among pediatric tumors; however, a subset of infants with neuroblastoma display spontaneous regression. The mechanism of spontaneous regression remains to be elucidated. TrkA plays an essential role in the differentiation and functionality of neurons; abundant TrkA expression is associated with fav.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.15
- DOI:
- 10.4238/2015.October.26.15
Biological activity of cytotoxic dendritic cells cocultured with cytokine-induced killer cells and their effect on acute leukemia cells
Authors: X.Y. Cheng and J.L. Li
We cocultured cytokine-induced killer (CIK) cells with dendritic cells (DCs) in vitro and investigated their proliferation, immunophenotype changes, secretory cytokine levels, and their antitumor effects on acute myeloid leukemia (AML) cells. DCs and CIK cells were acquired from healthy human peripheral blood mononuclear cells and cocultured as an experim.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.17
- DOI:
- 10.4238/2015.October.26.17
Role of proteinase-activated receptor-1 gene polymorphisms in susceptibility to chronic obstructive pulmonary disease
Authors: C.M. Yun and X.Y. Sang
We conducted a case-control study to investigate the association between PAR1 gene polymorphisms and the development of chronic obstructive pulmonary disease (COPD). A total of 270 patients with COPD and 270 control subjects were consecutively recruited between March 2012 and March 2014. A polymerase chain reaction restriction fragment length polymorphism.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.18
- DOI:
- 10.4238/2015.October.26.18
Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis
Authors: Y. Du, L. Gao , K. Zhang and J. Wang
The human IL6 [interleukin 6 (interferon, beta 2)] gene encodes IL-6, a cytokine which not only plays regulatory roles in inflammation, but may be also involved in the progression of cancer. Rs1800796 is a single nucleotide polymorphism (SNP) in the promoter region of IL6, and is associated with IL-6 production. A number of studies have been carried out t.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.20
- DOI:
- 10.4238/2015.October.26.20
Genetic mechanism associated with congenital cytomegalovirus infection and analysis of effects of the infection on pregnancy outcome
Authors: J.M. Li, H.F. Zhang, X.Q. Zhang, G.L. Huang, H.Z. Huang and W.W. Yu
We aimed to compare the diagnostic value of various detection methods for cytomegalovirus (CMV) infection, to investigate the genetic mechanism associated with CMV infection in pregnant women, and to analyze the risk of sequelae development in fetuses with CMV infection. A total of 300 participants who had the same immunosuppressive regimen and received p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.21
- DOI:
- 10.4238/2015.October.26.21
Mapping quantitative trait loci for five forage quality traits in a sorghum-sudangrass hybrid
Authors: J.Q. Li, L.H. Wang, Q.W. Zhan, Y.L. Liu, Q. Zhang, J.F. Li and F.F. Fan
The identification of quantitative trait loci (QTLs) affecting forage quality traits enables an understanding of the genetic mechanism of these loci. The aim of the present study was to detect QTLs for the whole-plant protein content (WP), whole-plant fat content (WF), neutral detergent fiber (NDF), acid detergent fiber (ADF), and whole-plant ash content .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.23
- DOI:
- 10.4238/2015.October.26.23
Genomic identification of group A bZIP transcription factors and their responses to abiotic stress in carrot
Authors: F. Que, G.L. Wang, Y. Huang, Z.S. Xu, F. Wang and A.S. Xiong
The basic-region/leucine-zipper (bZIP) family is one of the major transcription factor (TF) families associated with responses to abiotic stresses. Many members of group A in this family have been extensively examined and are reported to perform significant functions in ABA signaling as well as in responses to abiotic stresses. In this study, 10 bZIP fact.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.24
- DOI:
- 10.4238/2015.October.26.24
Protective effect of lyophilized recombinant human brain natriuretic peptide on renal ischemia/reperfusion injury in mice
Authors: X. Cao, H.Y. Xia, T. Zhang, L.C. Qi, B.Y. Zhang, R. Cui, X. Chen, Y.R. Zhao and X.Q. Li
Brain natriuretic peptide (BNP) has a protective effect on acute injury of the heart, brain, and lung. However, its role in acute kidney injury (AKI) remains unclear. The aim of this study was to investigate the effect of lyophilized recombinant human BNP (lrh-BNP) on AKI and the underlying molecular mechanisms. An experimental model for AKI was establish.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.26
- DOI:
- 10.4238/2015.October.26.26