Cloning, molecular characterization, and expression analysis of a nucleoporin gene (rgNUP98-96) from Rehmannia glutinosa
Authors: Y.H. Yang and M.J. Li
Nucleoporin 98 (NUP98) and nucleoporin 96 (NUP96) are essential components of the nuclear pore complex (NPC) in eukaryote cells. However, there is a lack of available information about complete Rehmannia glutinosa NUP98-96 (rgNUP98-96) sequences. Here, the full-length cDNA sequence of rgNUP96-98 was isolated from R. glutinosa using rapid amplification of .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.23
- DOI:
- 10.4238/2015.October.21.23
Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients
Authors: F.J. Wei, C.Y. Cai, P. Yu, J. Lv, C. Ling, W.T. Shi, H.X. Jiao, B.C. Chang, F.H. Yang, Y. Tian, M.S. Li, Y.H. Wang, L. Zou, J.M. Shi, L.M. Chen and W.D. Li
Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.25
- DOI:
- 10.4238/2015.November.30.25
Association between the interleukin-6 -174 G/C polymorphism and risk of ischemic stroke: a meta-analysis
Authors: X.F. Jin, D.L. Wang2, Y. Zhou and H. Xiong
Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase da.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.3
- DOI:
- 10.4238/2015.October.26.3
729G/C polymorphism in Toll-like receptor 4 results in increased susceptibility to bladder cancer
Authors: B. Wan, J. Tan, Q. Zeng, L.Y. He, Y. Gan, Y.B. Dai and K. Yao
In this study, the association between the 729G/C polymorphism in Toll-like receptor 4 (TLR4) and the risk of bladder cancer was investigated. A total of 376 patients with bladder cancer and 380 healthy volunteers from the Third Xiangya Hospital of Central South University (China) were enrolled in this study between January 20.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.26
- DOI:
- 10.4238/2015.November.30.26
RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer
Authors: S. SuÃ?¡rez-Villanueva, M.L. Ayala-Madrigal, J. Peregrina-Sandoval, N. MacÃ?Âas-GÃ?³mez, R. RamÃ?Ârez-RamÃ?Ârez, R. MuÃ?±iz-Mendoza, J.M. Moreno-Ortiz, M. Centeno-Flores, V. Maciel-GutiÃ?©rrez, E. Cabrales and M. GutiÃ?©rrez-Angulo
We analyzed a possible association between RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer (CRC). Genomic DNA samples were obtained from the peripheral blood of 176 Mexican patients with CRC at diagnosis and from 195 individuals that formed the control group. The polymorphisms were detected b.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.28
- DOI:
- 10.4238/2015.November.30.28
Association of the GSTM1 null polymorphism with breast cancer in a Mexican population
Authors: O. Soto-Quintana, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez, R. RamÃ?Ârez-PatiÃ?±o, A. Ramos-Silva, L.E. Figuera, D.I. Carrillo-Moreno, I.A. GutiÃ?©rrez-Hurtado, A.M. Puebla-PÃ?©rez, B. SÃ?¡nchez-Llamas and M.P. Gallegos-Arreola
The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion inthe mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotyp.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.2
- DOI:
- 10.4238/2015.October.26.2
Protective effects against and potential mechanisms underlying the effect of magnesium isoglycyrrhizinate in hypoxia-reoxygenation injury in rat liver cells
Authors: J. Zheng, G. Wu, G.X. Hu, Y.Z. Peng and X.J. Xiong
We examined the protective effects of magnesium isoglycyrrhizinate (MgIG) on hypoxia-reoxygenation injury in rat liver cells. Rat liver cells in the logarithmic growth phase were divided into the hypoxia-reoxygenation injury model group and MgIG pretreatment group (0.01, 0.1, 1, 10, 100 mg/mL). After 24-h pretreatment, we dete.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.23
- DOI:
- 10.4238/2015.November.30.23
Molecular characterization, tissue distribution, and immune reaction expression of karyopherins in the domestic silkworm (Bombyx mori)
Authors: J. Li, L. Wang, C. Qian, C.F. Zhang, L.S. Dai, Q.N. Liu, G.Q. Wei, Y. Sun, D.R. Liu, B.J. Zhu and C.L. Liu
Karyopherins, including alpha and beta types, are transport proteins in the eukaryotic cell that carry cargoes across nuclear pore complexes into or out of the nucleus. In this study, full open reading frames of one beta and three alpha types of karyopherin were cloned from cDNA of the domestic silkworm (Bombyx mori). The one beta and three alpha types&rs.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.1
- DOI:
- 10.4238/2015.October.26.1
A framework radiation hybrid map of buffalo chromosome 1 ordering scaffolds from buffalo genome sequence assembly
Authors: N.B. Stafuzza, B.C.M. Naressi, E. Yang, J.J. Cai and M.E.J. Amaral-Trusty
River buffalo chromosome 1 (BBU1) is a sub-metacentric chromosome homologous to bovine chromosomes 1 and 27. In this study, we constructed a new framework radiation hybrid (RH) map from BBU1 using BBURH5000 panel adding nine new genes (ADRB3, ATP2C1, COPB2, CRYGS, P2RY1, SLC5A3, SLC20A2, SST, and ZDHHC2) and one microsatellite (CSSM043) to the set of mark.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.5
- DOI:
- 10.4238/2015.October.26.5
Mutational analysis of BRCA1/2 gene and pathologic characteristics from Kazakh population with sporadic breast cancer in northwestern China
Authors: S.Y. Yang, D. Aisimutula, H.F. Li, Y. Hu, X. Du, J. Li and M.X. Luan
Mutations in the BRCA1/2 genes are associated with an increased risk of breast cancer, but no large-scale research have examined the BRCA1/2 mutations in Chinese Kazakh women. We evaluated the frequency and distributions of BRCA1 and BRCA2 gene mutations in Kazakh sporadic breast cancer patients and healthy women in China. The association between the clin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.11
- DOI:
- 10.4238/2015.October.26.11