Molecular characterization, tissue expression profile and SNP analysis of porcine GLP2R
Authors: Y.L. Chai, H.M. Ma and J. Jiang
Glucagon-like peptide-2 receptor (GLP2R), a member of the G-protein-coupled receptor family, plays an important role in intramuscular fat formation. Little is known, however, about porcine GLP2R. In the present study, GLP2R was cloned, and its expression in pig muscle characterized. By rapid amplification of cDNA ends, gene sequence was obtained from Shaz.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.14
- DOI:
- 10.4238/2015.October.21.14
Effect of wilfortrine on human hepatic cancer HepG2 cell proliferation potential in vitro
Authors: M. Yue, X.J. Shen, Y.X. Liu, X.Y. Lin, S.Q. Zhou and Y.H. Song
Liver cancers are characterized by high morbidity and mortality owing to few effective drugs for its treatment. Wilfortrine has several pharmacological effects, including an inhibitory effect on liver cancer cell proliferation. However, whether wilfortrine can induce liver cancer cell apoptosis has not been elucidated. We inve.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.12
- DOI:
- 10.4238/2015.November.30.12
Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer
Authors: J. Li, X.F. Jia, J. Liu, J.J. Liu and H.B. Zhao
The aim of this study was to study the relationship of EGFR DNA methylation with the severity of non-small-cell lung cancer (NSCLC). We enrolled 54 patients with NSCLC between March 2013 and June 2014 from Department of Cardiothoracic Surgery in our hospital. The methylation levels in the promoter region of the EGFR gene in ca.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.5
- DOI:
- 10.4238/2015.October.5.5
Multivariate analysis of backcross progeny of Passiflora L. (Passifloraceae) for pre-breeding genotype selection
Authors: C.A.F. Melo, M.M. Souza, A.G.R. Sousa, A.P. Viana and E.A. Santos
The Ward-MLM procedure was used to evaluate genetic variation in four backcross progenies and in their parents, hybrid F1 HD13 and donor parent Passiflora sublanceolata. Sixteen quantitative descriptors and five qualitative characteristics of relevance to ornamental flower production were assessed. Using the pseudo-F .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.15
- DOI:
- 10.4238/2015.November.30.15
Influence of ERCC2 gene polymorphisms on the treatment outcome of osteosarcoma
Authors: Z.F. Liu, A.L.J. Asila, K. Aikenmu, J. Zhao, Q.C. Meng and R. Fang
We conducted a prospective study to investigate the role of ERCC2 gene polymorphisms on the outcome of cisplatin-based treatment in patients with osteosarcoma. A total of 115 patients with osteosarcoma were included in our study. Genotyping of ERCC2 Asn312Asp (rs1799793) and Lys751Gln (rs13181) was performed using a matrix-assisted laser desorption/ioniza.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.17
- DOI:
- 10.4238/2015.October.21.17
Interferon-�±-2b as an adjuvant therapy prolongs survival of patients with previously resected oral muscosal melanoma
Authors: R. Wang , G. Jing, J. Lv, H. Song, C. Li, X. Wang, W. Xia, Y. Wu, G. Ren and W. Guo
Two major subtypes of melanoma include cutaneous melanoma and mucosal melanoma. The latter type is rare and usually occurs in the head and neck region. High-dose interferon-α-2b (IFN-α-2b) has proven effective in the treatment of cutaneous melanoma. Recently, a regimen of temozolomide plus cisplatin was reported mo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.8
- DOI:
- 10.4238/2015.October.5.8
Isolation and characterization of new microsatellite markers in red tail prawn, Fenneropenaeus penicillatus, an endangered species in China
Authors: Y. Yuan, J.B. Shangguan, Z.B. Li, Y.F. Ning, Y.S. Huang, B.B. Li and X.Q. Mao
Until recently, Fenneropenaeus penicillatus was considered a commercial shrimp species. However, in 2005, it was included on the Red List as an endangered species by the Chinese government. In this study, 19 new microsatellite markers in F. penicillatus were developed and tested in samples of 32 wild individu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.18
- DOI:
- 10.4238/2015.November.30.18
Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population
Authors: J.Y. Li, F. Tao, X.X. Wu, Y.Z. Tan, L. He and H. Lu
Impaired antioxidant defense increases the oxidative stress and contributes to the development of type 2 diabetes mellitus (T2DM). MnSOD and eNOS are important antioxidant enzymes. This aim of this study was to verify the association of MnSOD and eNOS tagSNPs with T2DM in a Chinese Han population. Four tagSNPs of MnSOD and eight tagSNPs of eNOS were detec.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.20
- DOI:
- 10.4238/2015.October.21.20
Expression of the 2-dehydro-3-deoxyphosphooctonate aldolase (KdsA) gene in mulberry leaves (Morus alba L.) is down-regulated under high salt and drought stress
Authors: X.B. Yang, S.L. Wu, D.P. Zhu, H. Wu, T. Jiang, Y.H. Qian and F. Jiao
The oligosaccharide 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) is a key component of lipopolysaccharide in Gram-negative bacteria, and is also part of the pectic polysaccharide rhamnogalacturonan (RG-II) of the plant cell wall. The enzyme KDO-8-phosphate synthase (KDO8Ps), encoded by the 2-dehydro-3-deoxyphosphooctonate aldolas.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.9
- DOI:
- 10.4238/2015.October.5.9
G-395A polymorphism in the promoter region of the KLOTHO gene and hypertension among elderly (90 years and older) Chinese individuals
Authors: L.L. Gao, X. Ding, D.M. Xie, M. Yang and B.R. Dong
The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We include.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.22
- DOI:
- 10.4238/2015.November.30.22