Multidrug resistance gene (MDR1) polymorphisms may not be directly associated with response to imatinib in chronic myeloid leukemia
Authors: J.L. Wang, H.J. Liu, F. Li, W.Y. Yang, J.M. Wang, S.F. Tan and Q. Wang
Our study aimed to investigate the association between multidrug resistance (MDR1) gene polymorphisms and the response to imatinib (IM) in chronic myeloid leukemia (CML). An electronic databases in PubMed, Cochrane Library, Wanfang, China National Knowledge Infrastructure, and VIP were searched using combinations of k.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.4
- DOI:
- 10.4238/2015.November.24.4
Novel single nucleotide polymorphisms of the bovine methyltransferase 3b gene and their association with meat quality traits in beef cattle
Authors: X. Liu, X.Y. Guo, X.Z. Xu, M. Wu, X. Zhang, Q. Li, P.P. Ma, Y. Zhang, C.Y. Wang, F.J. Geng, C.H. Qin, L. Liu, W.H. Shi, Y.C. Wang and Y. Yu
DNA methylation is essential for adipose deposition in mammals. We screened SNPs of the bovine DNA methyltransferase 3b (DNMT3b) gene in Snow Dragon beef, a commercial beef cattle population in China. Nine SNPs were found in the population and three of six novel SNPs were chosen for genotyping and analyzing a possible association with 16 meat quality trai.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.29.1
- DOI:
- 10.4238/2012.June.29.1
Keratins 17 and 19 expression as prognostic markers in oral squamous cell carcinoma
Authors: B.A. Coelho, G.T. Peterle, M. Santos, L.P. Agostini, L.L. Maia, E. Stur, C.V.M. Silva, S.O. Mendes, C.C.J. Alman�§a, F.V. Freitas, A.R. Bor�§oi, A.B. Archanjo, A.M.C. Mercante, F.D. Nunes, M.B. Carvalho, E.H. Tajara, I.D. Louro and A.M.A Silva-Conforti
Five-year survival rates for oral squamous cell carcinoma (OSCC) are 30% and the mortality rate is 50%. Immunohistochemistry panels are used to evaluate proliferation, vascularization, apoptosis, HPV infection, and keratin expression, which are important markers of malignant progression. Keratins are a family of intermediate f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.21
- DOI:
- 10.4238/2015.November.24.21
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
Authors: P.R.S. Rodrigues, L.L. Maia, M. Santos, G.T. Peterle, L.U. Alves, J.T. Takamori, R.P. Souza, W.M. Barbosa, A.M.C. Mercante, F.D. Nunes, M.B. Carvalho, E.H. Tajara, I.D. Louro and A.M.A. Silva-Conforti
The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been repo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.5
- DOI:
- 10.4238/2015.November.24.5
Detection limits of the strip test and PCR for genetically modified corn in Brazil
Authors: V.E. Nascimento, ��.V.R. Von Pinho, R.G. Von Pinho and A.D. do Nascimento J�ºnior
Brazilian legislation establishes a labeling limit for products that contain more than 1% material from genetically modified organisms (GMOs). We assessed the sensitivity of the lateral flow strip test in detection of the GMO corn varieties Bt11 and MON810 and the specificity and sensitivity of PCR techniques for their detection. For the strip test, the G.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.27.2
- DOI:
- 10.4238/2012.June.27.2
Targeting exogenous GDNF gene to the bovine somatic cell beta-casein locus for the production of transgenic bovine animals
Authors: X.M. Zhang, F.H. Luo, H.M. Ding, B. Li, J.J. Zhang and Y.J. Wu
Considerable attention is currently being directed toward methods for producing recombinant human proteins in the mammary glands of genetically modified transgenic livestock. However, the expression of inserted genes in transgenic animals is variable and often very low because of the randomness of the site of transgene integra.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.6
- DOI:
- 10.4238/2015.November.24.6
Suitable internal control microRNA genes for measuring miRNA abundance in pig milk during different lactation periods
Authors: Y.R. Gu, Y. Liang, J.J. Gong, K. Zeng, Z.Q. Li, Y.F. Lei, Z.P. He and X.B. Lv
Determination of an optimal set/number of internal control microRNA (miRNA) genes is a critical, but often undervalued, detail of quantitative gene expression analysis. No validated internal genes for miRNA quantitative PCR (q-PCR) in pig milk were available. We compared the expression stability of six porcine internal control miRNA genes in pig milk from.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.18.3
- DOI:
- 10.4238/2012.June.18.3
Physical mapping of 18S and 5S rDNA loci and histone H3 gene in grasshopper species of the subfamily Gomphocerinae (Acrididae)
Authors: L.C. Silva-Neto, A.C.S. Bernardino, V. Loreto and R.C. Moura
In this study, fluorescence in situ hybridization (FISH) analysis was used to determine and compare the numbers and chromosomal locations of two multigene families (rDNA and histone H3) in four Neotropical species of gomphocerine grasshoppers. FISH using the 18S rDNA probe identified a single site on the S9 chromosome.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.8
- DOI:
- 10.4238/2015.November.24.8
Angiotensin II type 1 receptor gene A1166C polymorphism and breast cancer susceptibility
Authors: L. Li, F. Wang, P.W. Lv, M.Z. Zhu, J.J. He, G.C. Guo, Y.T. Gu and M.L. Han
Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.9
- DOI:
- 10.4238/2015.November.24.9
Phylogenetic diversity of endophytic leaf fungus isolates from the medicinal tree Trichilia elegans (Meliaceae)
Authors: S.A. Rhoden, A. Garcia, C.J. Rubin Filho, J.L. Azevedo and J.A. Pamphile
Various types of organisms, mainly fungi and bacteria, live within vegetal organs and tissues, without causing damage to the plant. These microorganisms, which are called endophytes, can be useful for biological control and plant growth promotion; bioactive compounds from these organisms may have medical and pharmaceutical applications. Trichilia elegans .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.15.8
- DOI:
- 10.4238/2012.June.15.8