L. Ma
Effect of 1,25(OH)2D3 on the proliferation of human mesangial cells and their expression of Ki67
Previous studies have found that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3 or VD3] exerts many biological effects, including the inhibition of cell proliferation and induction of apoptosis, but its mechanism of action remains unclear. The goal of our investigation was to explore the effects of 1,25(OH)2D3 on the proliferation of cultured human mesangial cells and their .. Read More»
Genet. Mol. Res. 16(2): gmr16029191
DOI: 10.4238/gmr16029191
Expression and significance of miR-21 in multiple myeloma patients
The aim of the present study is to examine the expression level of peripheral mir-21 in multiple myeloma (MM) patients and to determine its clinical significance. MM patients (30), monoclonal gammopathy of undetermined significance (MGUS) patients (14), and normal controls (20) were recruited to determine the serum level of β2-MG, IgA and IgM, IgG, λ, κ, TP, ALB, Hb, LDH, and .. Read More»
Genet. Mol. Res. 15(1): gmr.15016892
DOI: 10.4238/gmr.15016892
Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma
Carcinogenesis of breast carcinoma is very complicated. Previous studies have suggested conflicting results regarding the association between Tyr113His and His139Arg microsomal epoxide hydrolase (mEH) gene polymorphisms and risk of breast carcinoma. We conducted a meta-analysis to examine the relationship between these polymorphisms and breast carcinoma risk. We searched the PubMed, EMBASE, and.. Read More»
Genet. Mol. Res. 14(2): http://dx.doi.org/2015.April.27.28
DOI: http://dx.doi.org/10.4238/2015.April.27.28
Development and Transferability of Microsatellites Markers for Species of the Saltans Group of Drosophila (Diptera: Drosophilidae)
The microsatellite markers (SSRs) are highly polymorphic, fast evolving, and regarded as neutral markers. Due to these traits, they have been widely used in population studies. The development of specific SSRs for a given species opens possibilities for the application, by means of transferability, in population studies of other species that are phylogenetically related, thereby optimizing time.. Read More»
Genet. Mol. Res. 19(4):
Neuroprotective effects of NEP1-40 and fasudil on Nogo-A expression in neonatal rats with hypoxic-ischemic brain damage
The hypoxic-ischemic encephalopathy caused by peripartum asphyxia is a serious disease in newborn infants, and effective therapies need to be developed to reduce injury-related disorders. We evaluated the effects of NEP1-40 and fasudil on Nogo-A expression in neonatal hypoxic-ischemic brain damage (HIBD) rats. Seven-day-old Wistar rats were randomly divided into con.. Read More»
Genet. Mol. Res. 10(4): 2011.November.29.9
DOI: 10.4238/2011.November.29.9
Efficacy of Artemisia annua polysaccharides as an adjuvant to hepatitis C vaccination
The traditional Chinese medicine Artemisia annua can prevent and treat hepatitis following an unclear mechanism. The aim of this study was to evaluate the effects of A. annua polysaccharides (AAP) on hepatitis C virus (HCV). A pcDNA3.1/NS3 expression vector was constructed. Ninety female BALB/c mice were randomly divided into six groups: high-dose AAP (1 mg/mL) + HCV/NS3 plasmid; middle-dose AA.. Read More»
Genet. Mol. Res. 14(2): 2015.May.11.29
DOI: 10.4238/2015.May.11.29
Cytotoxic, mutagenic and antimutagenic screening of Arenosclera brasiliensis acetone and ethanol extracts
The marine environment is a rich source of biologically active compounds with pharmacological properties. Marine organisms often produce secondary metabolites with structural features different from those produced by terrestrial ones, and the Phylum Porifera seems to be one of the most productive in this sense. This study was undertaken to provide data on mutagenic .. Read More»
Genet. Mol. Res. 7(2): vol7-2gmr460
DOI: 10.4238/vol7-2gmr460
Inhibitory effect of microRNA-27b on interleukin 17 (IL-17)-induced monocyte chemoattractant protein-1 (MCP1) expression
We investigated the effect of microRNA-27b (miR-27b), a gene expression regulatory factor, on the expression of monocyte chemoattractant protein-1 (MCP1) stimulated by interleukin 17 (IL-17). After IL-17 had been added to H9C2 cardiomyocytes, an miR-27b mimic was transfected into the H9C2 cells. The mRNA expression levels of miR-27b and MCP1 in the H9C2 cells were d.. Read More»
Genet. Mol. Res. 15(2): gmr.15027784
DOI: 10.4238/gmr.15027784
Isolation and characterization of polymorphic microsatellite loci in Aleurodicus dispersus (Hemiptera, Aleyrodidae)
Ten microsatellite markers were isolated and characterized from Aleurodicus dispersus, the spiraling whitefly, an exotic pest species that is considered to be one of the most serious agricultural pests on Hainan Island, China. The polymorphism of these loci was examined in individual whiteflies from Hainan Island and from the Canary Islands. All loci were polymorphi.. Read More»
Genet. Mol. Res. 10(4): 2011.October.18.2
DOI: 10.4238/2011.October.18.2
Development of two multiplex mini-sequencing panels of ancestry informative SNPs for studies in Latin Americans: an application to populations of the State of Minas Gerais (Brazil)
Admixture occurs when individuals from parental populations that have been isolated for hundreds of generations form a new hybrid population. Currently, interest in measuring biogeographic ancestry has spread from anthropology to forensic sciences, direct-to-consumers personal genomics, and civil rights issues of minorities, and it is critical for genetic epidemiolo.. Read More»
Genet. Mol. Res. 9(4): vol9-4gmr911
DOI: 10.4238/vol9-4gmr911
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