A.V.C. Coelho

Synergic effect of oral contraceptives, GSTP1 polymorphisms, and high-risk HPV infection in development of cervical lesions

• B.S. Chagas
• A.P.A.D. Gurgel
• S.S.L. Paiva Júnior
• R.C.P. Lima
• M.N. Cordeiro
• R.R. Moura
• A.V.C. Coelho
• K.C.G. Nascimento
• J.C. Silva Neto
• S. Crovella
• A.C. Freitas

Human papillomavirus (HPV) infection is considered a risk factor for cervical cancer. Even if the high-risk HPV (HR-HPV) infection is necessary, environmental co-factors and genetic susceptibility also play an important role in cervical cancer development. In this study, a possible association of rs1695 GSTP1 polymorphisms, HR-HPV infection, and oral contraceptive u.. Read More»

Genet. Mol. Res. 16(3): gmr16039742

DOI: 10.4238/gmr16039742

HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis

A.V.C. Coelho, R.R. Moura, S. Crovella and F. Celsi

Human leukocyte antigen (HLA)-G is a key tolerogenic molecule mainly expressed in the placenta and is crucial for implantation of the embryo and immunological tolerance of the fetus during pregnancy. However, under pathological conditions, such as cancer or viral infections, HLA-G can be expressed in other tissues. The gene coding for HLA-G (HLA-G, chromosome 6p21.3) presents numerous polymorph.. Read More»

Genet. Mol. Res. 15(3): gmr.15038263

DOI: 10.4238/gmr.15038263

A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil

A.V.C. Coelho, R.R. Moura, C.A.J. Cavalcanti, R.L. Guimarães,P. Sandrin-Garcia, S. Crovella and L.A.C. Brandão

Genetic association studies determine how genes influence traits. However, non-detected population substructure may bias the analysis, resulting in spurious results. One method to detect substructure is to genotype ancestry informative markers (AIMs) besides the candidate variants, quantifying how much ancestral populations contribute to the samples’ genetic background. The present study .. Read More»

Genet. Mol. Res. 14(1):

Role of inosine triphosphate pyrophosphatase gene variant on fever incidence during zidovudine antiretroviral therapy

A.V.C. Coelho, S.P.S. Silva, L. Zandonà, G. Stocco, G. Decorti and S. Crovella

Zidovudine, the antiretroviral drug used to treat HIV infection, commonly causes adverse effects, such as systemic fever and gastrointestinal alterations. In the present study, the potential role of inosine triphosphate pyrophosphatase (ITPA) gene variant on the incidence of adverse events during antiretroviral therapy (ART) of HIV with zidovudine was discussed. Ind.. Read More»

Genet. Mol. Res. 16(1): gmr16019373

DOI: 10.4238/gmr16019373