Human Genetics
Association between polymorphisms of fat mass and obesity-associated gene and metabolic syndrome in Kazakh adults of Xinjiang, China
Authors: Y.H. Hu, J.M. Liu, M. Zhang, R.L. Ma, H. Guo, K. Wang, J. He, Y.Z. Yan, D.S. Rui, F. Sun, L.T. Mu, Q. Niu, Y.S. Ding, J.Y. Zhang, S.G. Li and S.X. Guo
The aim of this study was to assess the association between three FTO polymorphisms (rs9939609, rs8057044, and rs1421085) and metabolic syndrome (MS)-related outcomes in the low-income, rural, nomadic minority Khazakh population in far western China. A total of 489 subjects (245 MS patients, 244 controls) were included in the study and DNA samples were ge.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.23
- DOI:
- 10.4238/2015.November.18.23
Intermedin protects against myocardial ischemia-reperfusion injury in hyperlipidemia rats
Authors: S.M. Yang1, J. Liu2 and C.X. Li1
Hyperlipidemia is a well-established risk factor for the development of coronary atherosclerosis, while intermedin (IMD) has been identified as a novel calcitonin/calcitonin gene-related peptide family member involved in cardiovascular protection. However, whether IMD protects against hyperlipidemia-associated myocardial ischemia/reperfusion (MI/R) injury.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.7
- DOI:
- 10.4238/2014.October.20.7
Restriction-ligation-free (RLF) cloning: a high-throughput cloning method by in vivo homologous recombination of PCR products
Authors: Y. Wang, Y. Liu, J. Chen, M.J. Tang, S.L. Zhang, L.N. Wei, C.H. Li and D.B. Wei
In this study, we optimized a restriction-ligation-free (RLF) method to save time and cost of constructing multiple plasmids with the same gene insert, and examined the efficacy of RLF on high-throughput multi-plasmid cloning. This method utilizes the precise DNA repair and recombination systems within Escherichia coli, which .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.19
- DOI:
- 10.4238/2015.October.9.19
Gli1 expression in pancreatic ductal adenocarcinoma and its clinical significance
Authors: Y. Abula, C. Yi, X.-Y. Wang, M. Wang, R.-Y. Qin, Y.-Q. Guo, H. Lin and H.-J. Li
The aim of this study was to explore the correlation between the expression levels of Gli1 and p53 in pancreatic ductal adenocarcinoma (PDAC) and its pathological significance. Immunohistochemistry (IHC) was employed to measure the expression level of Gli1 and p53 in 85 sets of paraffin-embedded PDAC and corresponding para-car.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.21
- DOI:
- 10.4238/2015.October.9.21
Expression and significance of the imprinted gene PEG10 in placenta of patients with preeclampsia
Authors: X.Y. Liang, X. Chen, Y.Z. Jin, X.O. Chen and Q.Z. Chen
The aim of this study was to investigate the expression and significance of the imprinted gene PEG10 (paternally expressed gene 10) in preeclampsia placental tissue. Quantitative real-time reverse transcriptase polymerase chain reaction and immunohistochemistry to evaluate mRNA and protein expression and distribution of PEG10 in placental tissues obtained.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.18.2
- DOI:
- 10.4238/2014.December.18.2
APOA5 -1131T/C polymorphism and coronary artery disease susceptibility in Chinese population: an updated meta-analysis and review
Authors: J. Zhang, D.G. Wan, H.L. Song and W.G. Zhang
Although many studies have investigated the association of the APOA5 -1131T/C polymorphism with coronary artery disease (CAD), definite conclusions have not been drawn. To understand the effects of the APOA5 -1131T/C polymorphism on the risk of developing CAD, we performed an updated meta-analysis in the Chinese population. Re.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.22
- DOI:
- 10.4238/2015.October.9.22
Porous tantalum rods for treating osteonecrosis of the femoral head
Authors: Z.H. Liu, W.S. Guo, Z.R. Li, L.M. Cheng, Q.D. Zhang, D.B. Yue, Z.C. Shi, B.L. Wang, W. Sun and N.F. Zhang
This study evaluated the outcomes of using porous tantalum rods for the treatment of osteonecrosis of the femoral head (ONFH). We performed core decompression and inserted porous tantalum implants in 149 patients (168 consecutive hips) with ONFH. Hips had large (65), medium (64), or small (39) lesions; 63 lesions were lateral, 68 were central, and 35 were.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.10
- DOI:
- 10.4238/2014.October.20.10
Immunohistochemical expression of nestin in rhabdomyosarcoma: implications for clinicopathology and patient outcome
Authors: S. Glumac, S. Pejic, R. Kovacevic, D. Dundjerovic, R. Davidovic, D. Ristic and J. Sopta
Rhabdomyosarcoma (RMS) is a highly malignant cancer. Over the last two decades, prognosis for RMS patients has significantly improved, with the exception of those in the high-risk group. In order to identify new prognostic factors, we investigated the expression of nestin in RMS cells and its correlation with clinicopathological features and patient outco.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.29
- DOI:
- 10.4238/2015.November.18.29
Effect of NB-UVB on levels of MCP-1 and CCR6 mRNA in patients with psoriasis vulgaris
Authors: M.L. Gao and A.G. Wang
The aim of this study is to explore the effect of narrow band ultraviolet B (NB-UVB) on the chemokine receptor CCR6 mRNA levels in patients with psoriasis. Psoriasis area and severity index (PASI) values were recorded before and after the treatment with NB-UVB phototherapy of 30 psoriasis vulgaris patients. The reverse transcr.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.1
- DOI:
- 10.4238/2015.October.9.1
Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study anda meta-analysis
Authors: W.G. Hu, R.J. Pan, W. Cai, Z.T. Wang and Z.G. Zhu
The association between the human 8-oxoguanine glycosylase 1 (hOGG1) gene Ser326Cys polymorphism (rs1052133) and gastric cancer has been widely evaluated, yet a definitive answer to whether this association exists is lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-ana.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.31
- DOI:
- 10.4238/2015.November.18.31