Human Genetics
Investigation of clinical diagnosis and liver biopsy diagnosis in cases of patients with chronic HBV infection
Authors: W.-Q. Shi, W. Ni and Y.-L. Yang
The aim of this study was to investigate the pathomorphological changes of chronic hepatitis B virus (HBV) infection and the coincidence between clinical and pathological diagnosis. Hematoxylin and eosin staining and immunohistochemistry for HBsAg and HBcAg were performed on 97 liver biopsy specimens collected from 97 patients.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.13.16
- DOI:
- 10.4238/2014.February.13.16
Correlation and interventional embolization therapy of posterior intercostal arteries-induced hemoptysis
Authors: Y.P. Chen, Y.G. Chen, F. Jiang and J.M. Chen
The incidence of posterior intercostal arteries-induced hemoptysis, its correlation with primary diseases, and the value of interventional embolization therapy were investigated. Clinical data, multislice spiral computed tomography (MSCT), digital subtraction angiography (DSA), and other imaging data of 143 cases of hemoptysis.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.10
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.10
Comparison of the prevalence and distribution of human papillomavirus infection and cervical lesions between urban and native habitants of an Amazonian region of Peru
Authors: M. Martorell, J.A. Garcia-Garcia, D. Gomez-Cabrero, A. del Aguila
We made a study of the prevalence of human papillomavirus (HPV) and cervix lesions in an Amazonian Bora native population (Bn) and compared it with the prevalence in an urban population in Iquitos (Iq). We also examined the distribution of HPV types among abnormal cervical smears in the Iq population. Swabs and cytologies were collected from 472 females. .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.6.14
- DOI:
- 10.4238/2012.August.6.14
Induction of apoptosis in human cervical carcinoma Hela cells with active components of Menispermum dauricum
Authors: J.Y. Wang, S. Sun, L. Liu and W.S. Yang
Menispermum dauricum DC possesses a wide range of pharmacological effects. In this study, the mechanism of apoptosis induced by active components of M. dauricum was investigated in the human cervical carcinoma HeLa cell line. HeLa cells were treated with different M. dauricum concentrations over different time periods. The pro.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.13.17
- DOI:
- 10.4238/2014.February.13.17
Association of cyclin D1 and survivin expression with sensitivity to radiotherapy in patients with nasopharyngeal carcinoma
Authors: S.M. Fu, M.X. Xu, S.M. Lin, Z. Liang and J.H. Cai
The association between cyclin D1 and survivin protein expressions with radiotherapy sensitivity in patients with nasopharyngeal carcinoma was investigated. Biopsy specimens of 72 patients with nasopharyngeal carcinoma were collected before the initiation of radiotherapy (49 cases were in the radiationsensitive group and 23 ca.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.6
- DOI:
- 10.4238/2014.February.14.6
Population structure and genetic diversity in natural populations of Theobroma speciosum Willd. Ex Spreng (Malvaceae)
Authors: L.D. Giustina, L.N. Luz, F.S. Vieira, F.S. Rossi, C.R.A. Soares-Lopes, T.N.S. Pereira and A.A.B. Rossi
The genus Theobroma found in the Amazon region is composed of 22 species, including Theobroma speciosum, better known as cacauí. These species are constantly threatened by forest fragmentation caused by human activities and require conservation strategies and management aimed at preserving them in their natural environm.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.5
- DOI:
- 10.4238/2014.February.14.5
Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population
Authors: J.M. Moreno-Ortiz, M. GutiÃ?©rrez-Angulo, M. Partida-PÃ?©rez, J. Peregrina-Sandoval, R. RamÃ?Ârez-RamÃ?Ârez, R. MuÃ?±iz- endoza, S. SuÃ?¡rez-Villanueva, M. Centeno-Flores, V. Maciel-GutiÃ?©rrez, J.E. Cabrales-Vazquez and M.L. Ayala-Madrigal
Colorectal cancer (CRC) is characterized by enhanced expression and activity of several metalloproteinases (MMPs), including MMP13 and MMP7, which play an important role in tumor invasion and metastasis. The objective of this study was to analyze the association of functional MMP7-181A/G and MMP13-77A/G promoter polymorphisms .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.1
- DOI:
- 10.4238/2014.February.14.1
Association of the g.27563G>A osteoprotegerin genetic polymorphism with bone mineral density in Chinese women
Authors: Y.P. Liu, D.W. Zhao, W.M. Wang, B.J. Wang, Y. Zhang and Z.G. Li
Osteoporosis is a common multifactorial disease in postmenopausal women. This study aimed to investigate the association of the g.27563G>A osteoprotegerin (OPG) genetic polymorphism with bone mineral density (BMD) and osteoporosis. A case-control study was carried out with 435 osteoporosis postmenopausal women cases and 442.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.9
- DOI:
- 10.4238/2014.February.14.9
Meta analysis of angiotensin-converting enzyme I/D polymorphism as a risk factor for preeclampsia in Chinese women
Authors: W.G. Zhong, Y. Wang, H. Zhu and X. Zhao
Preeclampsia affects 3-8% of pregnancies and is a major cause of maternal and perinatal morbidity and mortality worldwide. Inappropriate activation of the renin-angiotensin system may play a role in the development of preeclampsia. An insertion/deletion polymorphism in the angiotensin-converting enzyme gene (ACE-I/D) has been associated with differences i.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.21.1
- DOI:
- 10.4238/2012.May.21.1
Screening and prevention of neonatal glucose 6-phosphate dehydrogenase deficiency in Guangzhou, China
Authors: J. Jiang, B. Li, W. Cao, X. Jiang, X. Jia, Q. Chen and J. Wu
We aimed to summarize the results of screening protocol and prevention of neonatal glucose 6-phosphate dehydrogenase (G6PD) deficiency during a 22-year-long period to provide a basis of reference for the screening of this disease. About 1,705,569 newborn subjects in Guangzhou City were screened for this deficiency. Specimens w.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.13
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.13