Human Genetics
Constructing gene network based on biclusters of expression data
Authors: F. Liu, L. Yang, Z.Z. Tian, P. Wu and S.L. Sun
Two genes can be co-regulated and possibly have the similar function if they are similarly expressed, which provides a theoretical basis for construction of gene regulatory networks using gene expression data. Herein, a new method of gene regulatory network was constructed based on biclusters in this paper. Given a bicluster, .. Read More»
- Genet. Mol. Res. 15(2):
Correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer among the Kazakh ethnic group in Xinjiang
Authors: M. Zeng, Y. Lv, H.F. Wang, H.A. Yiguli, J.R. Zhang and A. Yisikandaer
This study aimed to investigate the correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer (EC) among the Kazakh ethnic group in Xinjiang. CYP1A1 and GSTM1 gene polymorphisms were detected using peripheral blood from 86 subjects belonging to families with EC and 82 control subjects. Additi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.19
- DOI:
- 10.4238/2015.December.29.19
Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis
Authors: Y.-F. Yu, Z.-G. Han, W.-B. Guo, G.-J. Zhang, J.-K. Yang, F.-L. Wu, Q.-Y. Ou, Y.-H. Li, X.-Y. Cai, Z.-N. Zhan, J.-H. Chen, W.-L. Xie, L. Tang and C.-D. Liu
It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.1
- DOI:
- 10.4238/2015.December.29.1
Correlation between p53 and epidermal growth factor receptor expression in breast cancer classification
Authors: X.Z. Wang, Q. Liu, J.J. Sun, W.S. Zuo, D.W. Hu, S.G. Ma, D.B. Mu and Z.Y. Yu
This study aimed to explore new opportunities for developing targeted therapy for triple-negative breast cancer (TNBC) by analyzing the significance and association between p53 and epidermal growth factor receptor (EGFR) expression in different molecular subtypes of breast cancer. The clinical and pathological data of 264 patients with breast cancer recei.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.28.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.28.10
Potential role of heat-shock proteins in giant cell tumors
Authors: J.T. Chen, A. Younusi, L. Cao, Z. Tian, Y.J. Zhou and X.H. Song
We investigated the differential expression protein profile of giant cell tumors (GCTs), which can be used to monitor the tumor’s recurrence and metastasis, to provide preliminary results for further study. We also explored heat-shock protein (HSP) inhibitor that prevents tumors from recurring and migrating. A stable isotope-labeling strategy using .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.24
- DOI:
- 10.4238/2015.December.29.24
ORMDL3 variants associated with bronchiolitis susceptibility in a Chinese population
Authors: X.T. Liu, L. Ren, L.L. Zhou, Q.Y. Xiao, Y. Deng and E.M. Liu
Recent studies revealed common genetic risks for both viral bronchiolitis and asthma. Genome-wide association studies revealed that rs7216389 in the ORMDL3 gene is associated with childhood asthma. We conducted a case-control study examining the associations between ORMDL3 polymorphisms (rs7216389, rs12603332, and rs11650680) and bronchiolitis susceptibil.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.25
- DOI:
- 10.4238/2015.December.29.25
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer
Authors: J.P. Kleine, C.M. Camargo-Kosugi, C.V. Carvalho, F.C. Silva and I.D.C.G. Silva
The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer. Genotypes of 222 women were an.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.3
- DOI:
- 10.4238/2015.December.29.3
Distribution of forensic marker allelic frequencies in Pernambuco, Northestern Brazil
Authors: S.M. Santos, C.A. Souza2, K.C.N. Rabelo, P.R.E. Souza,R.R. Moura, T.C. Oliveira, and S. Crovella
Pernambuco is one of the 27 federal units of Brazil, ranking seventh in the number of inhabitants. We examined the allele frequencies of 13 short tandem repeat loci (CFS1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, FGA, TH01, vWA, and TPOX), the minimum recommended by the Federal Bureau of Investigation and commonly used in fore.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.2
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.2
Association of TNF-�± G308A gene polymorphism in essential hypertensive patients without type 2 diabetes mellitus
Authors: N. Ghodsian, M. Akhlaghi, V. Ramachandran, F. Heidari, P. Haghvirdizadeh, S.A. Eshkoor, A. Etemad, J.A. Jamaluddin and P. Ismail
This study aims to investigate the effects of tumor necrosis factor alpha (TNF-α) G308A gene polymorphism on essential hypertension (EHT) with or without type 2 diabetes mellitus (T2DM). The project was conducted on buccal epithelial and blood cells for case and control patients, respectively. Epithelial cells were obtained from the inner part of th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.4
- DOI:
- 10.4238/2015.December.29.4
Association of CD14 C159T polymorphism with atopic asthma susceptibility in children from Southeastern China: a case-control study
Authors: Y.N. Zhang, Y.J. Li, H. Li, H. Zhou and X.J. Shao
CD14 is involved in primary immune and inflammatory responses. The -159 C/T variation in the CD14 gene plays an important role in regulating CD14 expression and has been associated with the susceptibility to various diseases, including allergies. In this study, we examined the association between the C-159T polymorphism and atopic asthma susceptibility in.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.3