Human Genetics
Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2
Authors: N.I. Hanafi, A.S. Mohamed, J. Md Noor, N. Abdul Hamid Hasani, R. Siran, N.J. Osman, S. Ab Rahim and S.H. Sheikh Abdul Kadir
Ursodeoxycholic acid (UDCA) is used to treat liver diseases and demonstrates cardioprotective effects. Accumulation of the plasma membrane sphingolipid sphingomyelin in the heart can lead to atherosclerosis and coronary artery disease. Sphingomyelinases (SMases) break down sphingomyelin, producing ceramide, and inhibition of S.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028150
- DOI:
- 10.4238/gmr.15028150
A systematic review of the intergenerational aspects and the diverse genetic profiles of Huntington�s disease
Authors: L.A. Agostinho, S.R. dos Santos, R.M.P. Alvarenga and C.L.A. Paiva
Huntington’s disease (HD) is a rare progressive and fatal neurogenetic degenerative disease, characterized by movement and personality disorders and by progressive dementia. Its prevalence varies by ethnic origin and different genetic profiles predisposing individuals to HD in each population. The prevalence of HD is 5-10 per 100,000 individuals in .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.6
- DOI:
- 10.4238/2013.June.13.6
Relationship between the G75A polymorphism in the apolipoprotein A1 (ApoA1) gene and the lipid regulatory effects of pravastatin in patients with hyperlipidemia
Authors: T.N. Liu, C.T. Wu, F. He, W. Yuan, S.X. Li, H.W. Li, H.Y. Yu and M. Wu
In this study, we investigated the relationship between the G75A polymorphism in the apolipoprotein A1 (ApoA1) gene and the lipid regulatory effect of pravastatin in patients with hyperlipidemia. A total of 179 patients were divided into two groups: the pravastatin (N = 97) and policosanol (N = 82) treatment groups. The total .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028216
- DOI:
- 10.4238/gmr.15028216
Analysis of genetic diversity among Chinese wild Vitis species revealed with SSR and SRAP markers
Authors: Z.B. Jing, X.P. Wang and J.M. Cheng
The genetic diversity among 80 Vitis materials including 62 indigenous accessions of 17 wild Vitis species in China and 7 interspecific hybrids, 10 V. vinifera L. cultivars, and 1 V. riparia Michaux were evaluated by simple sequence repeat and sequence-related amplified polymorphism markers. A total of 10 simple sequence repeat primers and 11 sequence-rel.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.5
- DOI:
- 10.4238/2013.June.13.5
Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk
Authors: J. Ren, B.Z. He, T.S. Zhang, S.P. Lu and T. Yan
The aim of this meta-analysis was to assess the association between a polymorphism (-3860 G > A) in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer susceptibility. Relevant studies were retrieved from the PubMed and EMBase databases, and additionally evaluated for conformance with the inclusion criteria. The odds rati.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028353
- DOI:
- 10.4238/gmr.15028353
Development and characterization of microsatellite markers of the eastern keelback mullet (Liza affinis)
Authors: L. Liu, T.X. Gao, Z.Q. Han, C.H. Li, D.R. Sun and N. Song
Twenty-four polymorphic microsatellite loci were isolated and characterized for Liza affinis using a (GT)13-enriched genomic library. The number of alleles per locus ranged from 3 to 9, with a mean number of 6.250. The observed and expected heterozygosities ranged from 0.417 to 1.000 and from 0.550 to 0.861, with an average of.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028380
- DOI:
- 10.4238/gmr.15028380
Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients
Authors: R. Nemati, J. Lu, V. Ramachandran, A. Etemad, M. Heidari, M.J. Yahya, R. Roozafzoon and P. Ismail
The aim of this study was to determine whether C34T, a common polymorphism of the adenosine monophosphate deaminase 1 gene (AMPD1), is associated with essential hypertension (EH). We hypothesize that C34T is associated with the development of EH. A case-control design was used for this study. The DNA was extracted using a comm.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026241
- DOI:
- 10.4238/gmr.15026241
Cloprostenol and pregnant mare serum gonadotropin promote estrus synchronization, uterine development, and follicle-stimulating hormone receptor expression in mice
Authors: S. Wei, Z. Gong, L. An, T. Zhang, H. Dai and S. Chen
This study investigated the effects of pregnant mare serum gonadotropin (PMSG) and cloprostenol (CLO) on estrus induction and synchronization, uterine development, and follicle-stimulating hormone receptor (FSHR) expression in mice. A total of 105 Kunming pre-puberty mice were divided into seven subgroups. Three PMSG subgroups were injected intraperitonea.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.12
- DOI:
- 10.4238/2015.June.29.12
Anti-prostate cancer effects of CTL cell induction in vitro by recombinant adenovirus mediated PSMA/4-1BBL dendritic cells: an immunotherapy study
Authors: C.-G. Sui, D. Wu, F.-D. Meng, M.-H. Yang and Y.-H. Jiang
This study aimed to examine anti-prostate cancer immune response induced by dendritic cells (DCs) transduced with PSMA/4-1BBL recombinant adenoviruses in vitro. Ad-PSMA, Ad-4- 1BBL, and Ad-GFP were transfected into DCs derived from peripheral blood of healthy volunteers. Ad-PSMA/4-1BBL-DC, Ad-PSMA-DC, Ad-4-1BBL-DC, Ad-GFP-DC, and normal-DC, PSMA and 4-1BB.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.14
- DOI:
- 10.4238/2015.June.29.14
Characterization of microRNAs from goat (Capra hircus) by Solexa deep-sequencing technology
Authors: Y.H. Ling, J.P. Ding, X.D. Zhang, L.J. Wang, Y.H. Zhang, Y.S. Li, Z.J. Zhang and X.R. Zhang
MicroRNAs (miRNAs) are an important class of small noncoding RNAs that are highly conserved in plants and animals. Many miRNAs are known to mediate a myriad of cell processes, including proliferation and differentiation, via the regulation of some transcription and signaling factors, which are closely related to muscle development and disease. In this stu.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.4
- DOI:
- 10.4238/2013.June.13.4