Human Genetics
Aldehyde dehydrogenase 2 protects human umbilical vein endothelial cells against oxidative damage and increases endothelial nitric oxide production to reverse nitroglycerin tolerance
Authors: X.Y. Hu, Q. Fang, D. Ma, L. Jiang, Y. Yang, J. Sun, C. Yang and J.S. Wang
Medical nitroglycerin (glyceryl trinitrate, GTN) use is limited principally by tolerance typified by a decrease in nitric oxide (NO) produced by biotransformation. Such tolerance may lead to endothelial dysfunction by inducing oxidative stress. In vivo studies have demonstrated that aldehyde dehydrogenase 2 (ALDH2) plays impor.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027822
- DOI:
- 10.4238/gmr.15027822
Association between PDCD1, CTLA4, and MECP2 gene polymorphisms and systemic lupus erythematosus in the Chinese Northern Han
Authors: H.R. Dong, H.S. Li, S.C. Wang, Q.M. Balin and P.Y. Chang
Systemic lupus erythematosus (SLE) is an autoimmune disease that results in chronic inflammation of different organ systems. Several susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes has yet to be determined. The programmed cell death 1 gene (PDCD1), the cytotoxic T-lymphocyte-associated p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.29
- DOI:
- 10.4238/2015.December.21.29
Endometrial expression of telomerase, progesterone, and estrogen receptors during the implantation window in patients with recurrent implantation failure
Authors: N. Long, N. Liu1, X.L. Liu, J. Li, B.Y. Cai and X. Cai
Telomerase; ER alpha; RIF; Implantation window.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027849
- DOI:
- 10.4238/gmr.15027849
Association between polymorphisms in the interleukin-10 gene and risk of abdominal aortic aneurysm
Authors: F. Wang, Q.Q. Quan, C.L. Zhang, Y.B. Li and T.B. Jiang
In this case-control study, we attempted to investigate the role of three common single nucleotide polymorphisms (SNPs; -1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) in the IL-10 gene in the development of abdominal aortic aneurysm in a Chinese population. Three hundred and eighty-one patients with abdominal aortic aneurysm and age- and ge.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.32
- DOI:
- 10.4238/2015.December.21.32
Cancer classification based on gene expression using neural networks
Authors: H.P. Hu, Z.J. Niu, Y.P. Bai and X.H. Tan
Based on gene expression, we have classified 53 colon cancer patients with UICC II into two groups: relapse and no relapse. Samples were taken from each patient, and gene information was extracted. Of the 53 samples examined, 500 genes were considered proper through analyses by S-Kohonen, BP, and SVM neural networks. Classification accuracy obtained by S-.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.33
- DOI:
- 10.4238/2015.December.21.33
Changes in T-lymphocytes in lung cancer patients after hyperthermic intraperitoneal chemotherapy or radiotherapy
Authors: L. Yan, M. Wu, N. Ba, G. Shi, L. Wang and H. Zhang
We investigated dynamic changes in T-lymphocyte subsets after hyperthermic intraperitoneal chemotherapy (HIPEC) or radiotherapy using flow cytometry. A total of 1423 lung cancer patients admitted to our hospital between October 2012 and July 2015 were enrolled, and age-matched healthy individuals served as controls. Peripheral.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027865
- DOI:
- 10.4238/gmr.15027865
Epigallocatechin-3-gallate protects retinal vascular endothelial cells from high glucose stress in vitro via the MAPK/ERK-VEGF pathway
Authors: L. Zhang, Z.K. Zhang and S. Liang
Diabetic retinopathy (DR) is a frequent microvascular complication of diabetes, and one of the most common causes of legal blindness in the world. Epigallocatechin-3-gallate (EGCG) produces an anti-oxidative and anti-inflammatory effect against various human diseases. In this study, we determined the effect of EGCG on a human .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027874
- DOI:
- 10.4238/gmr.15027874
HPV infection-associated anogenital cyto-colpo-histological findings and molecular typing in HIV-positive women
Authors: F.K. Tso, C.L.L. Rodrigues, J.E. Levi, M.G. Mattosinho de Castro Ferraz, N.M.G. Speck and J.C.L. Ribalta
HIV and human papillomavirus (HPV) coinfection is increasing, especially in the anal canal (AC) and cervico-vaginal regions.We identified anal epithelium abnormalities related to high-risk HPV (HR-HPV) lesions in the lower genital tracts (LGTs) of HIV-positive women, described the HPV genotypes identified, and assessed the expression of E6/E7 oncogenes in.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.36
- DOI:
- 10.4238/2015.December.21.36
CXCL12 G801A polymorphism and susceptibility to glioma: a case�control study
Authors: S.F. Chang, S.L. Li, B. Yang, K.M. Yao, R.H. Miao, G.F. Liang and K.M. Zhang
Previous studies have demonstrated that the CXCL12 G801A polymorphism is closely correlated with tumor susceptibility. In addition, the CXCL12/CXCR4 pathway is closely related to proliferation, metastasis, and invasion of glioma. However, the genetic effects of the CXCL12 G801A polymorphism on glioma risk in Chinese populations remain unknown. In this stu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.9
- DOI:
- 10.4238/2015.December.21.9
Association between XPG gene polymorphisms and development of gastric cancer risk in a Chinese population
Authors: Y.B. Feng, D.Q. Fan, J. Yu and Y.K. Bie
We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene (rs2094258, rs751402 and rs17655) in the development of gastric cancer in a Chinese population. Between January 2012 and December 2014, samples from a .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027877
- DOI:
- 10.4238/gmr.15027877