Human Genetics
Expression of IL-21 in rats with inflammatory bowel disease
Authors: J.N. Mao, Y.S. Shen, X.Y. Luo and Y.L. Zhi
The purpose of this study was to investigate the expression of interleukin (IL)-21 in rats with inflammatory bowel disease (IBD). Fifty adult Wistar rats were randomly divided into two groups: DSS, in which IBD was induced by giving the rats 7% DSS for seven days in their water, and a water control. Blood samples were collected and the concentration of IL.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.33
- DOI:
- 10.4238/2015.December.16.33
Association between the XPG gene Asp1104His polymorphism and lung cancer risk
Authors: B. Zhou, X.M. Hu and G.Y. Wu
It has been suggested that the xeroderma pigmentosum complementation group G (XPG) gene Asp1104His polymorphism is linked to susceptibility to lung cancer. However, the results from the published studies are contradictory rather than conclusive. With this meta-analysis, we aimed to achieve a better understanding of the effects.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027395
- DOI:
- 10.4238/gmr.15027395
Ability of HMGB1 protein to bind to intrinsically bent and non-bent DNA sites in the AMPD2 gene amplicon
Authors: K.J.R. Passos, A. Fiorini, F.R. Rosado, D.V.B. Freitas, Q.A. Lima Neto, J.R. Pattaro Junior, V.P. Gaspar and M.A. Fernandez
HMGB-like proteins are architectural chromatin factors, and their function is heavily dependent on their ability to interact with DNA (especially non-canonical DNA structures). HMGB1 is involved in many DNA processes, and dysregulation of HMGB protein expression has profound effects on cellular transcription, resulting in seve.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027441
- DOI:
- 10.4238/gmr.15027441
Genetic parameters for carcass traits and body weight using a Bayesian approach in the Canchim cattle
Authors: S.L.C. Meirelles, F.B. Mokry, A.C. EspasandÃ?Ân, M.A.D. Dias, M.M. Baena and L.C. de A. Regitano
Correlation between genetic parameters and factors such as backfat thickness (BFT), rib eye area (REA), and body weight (BW) were estimated for Canchim beef cattle raised in natural pastures of Brazil. Data from 1648 animals were analyzed using multi-trait (BFT, REA, and BW) animal models by the Bayesian approach. This model i.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027471
- DOI:
- 10.4238/gmr.15027471
Increased androgen receptor messenger RNA in frontal-parietal hair follicles of women with androgenetic alopecia
Authors: F. Richeti, C. Kochi, M.N. Rocha, C. Santâ��Anna Corr�ªa, R. Lazzarini, R.M. Guazzelli, R.F. Mendon�§a, M.R. Melo and C.A. Longui
Normal testosterone levels are frequently observed in women with androgenetic alopecia (AGA), suggesting the involvement of androgen sensitivity in this condition. Androgen sensitivity is related to androgen receptor (AR) messenger RNA (mRNA) production in hair follicles and is negatively related to the number of CAG repeats present in exon 1 of the AR ge.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.February.28.19
- DOI:
- 10.4238/2013.February.28.19
IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population
Authors: S.X. Yang, F. Chen, J.W. Zhang, Z.Q. Sun and B.P. Chen
IL-16 plays an important role in affect the secretion of tumor-related inflammatory cytokines. We aimed to assess the role of interleukin-16 (IL-16) rs4778889 T/C and rs11556218 T/G polymorphisms in the occurrence of renal cell cancer (RCC). This study is composed of 274 RCC patients and 274 control subjects. Genotyping of pol.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027553
- DOI:
- 10.4238/gmr.15027553
Association between the interleukin-1�² gene -511C/T polymorphism and ischemic stroke: an updated meta-analysis
Authors: W. Yan, Z.Y. Chen, J.Q. Chen and H.M. Chen
Numerous studies have investigated the relationship between the interleukin-1β gene (IL1B) -511C/T polymorphism and ischemic stroke (IS) risk. However, the results are inconsistent. We performed this meta-analysis of all available case-control studies that evaluated the relationship between the IL1B -511C/T polymorphism a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027580
- DOI:
- 10.4238/gmr.15027580
Construction of a primary DNA fingerprint database for cotton cultivars
Authors: Y.C. Zhang, M. Kuang, W.H. Yang, H.X. Xu, D.Y. Zhou, Y.Q. Wang, X.A. Feng, C. Su and F. Wang
Forty core primers were used to construct a DNA fingerprint database of 132 cotton species based on multiplex fluorescence detection technology. A high first successful ratio of 99.04% was demonstrated with tetraplex polymerase chain reaction. Forty primer pairs amplified a total of 262 genotypes among 132 species, with an average of 6.55 per primer and v.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.30.3
- DOI:
- 10.4238/2013.January.30.3
Th17/Treg cell expression in children with primary nephritic syndrome and the effects of ox-LDL on Th17/Treg cells
Authors: Y.Y. Li, S.G. Wei, X. Zhao, Y.Z. Jia, Y.F. Zhang and S.Z. Sun
To investigate the role of T-helper cells/Treg (Th17/Treg) and morbidity factors related to primary nephritic syndrome (PNS) in children, as well as the influence of ox-low density lipoprotein (ox-LDL) on Th17/Treg expression in children with PNS. To clarify the pathogenesis of PNS in children, 50 children with PNS treated in .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027669
- DOI:
- 10.4238/gmr.15027669
Change in heritability estimates due to half-sib family selection in the maize variety Pahari
Authors: M. Noor, D. Shahwar, H. Rahman, H. Ullah, F. Ali, M. Iqbal, I.A. Shah and I. Ullah
This research was carried out at the Agriculture Research Farm, Khyber Pakhtunkhwa Agricultural University, Peshawar, and the Cereal Crops Research Institute, Pirsabak, Nowshera, during 2009 and 2010. Half-sib families (HS) derived from the maize variety Pahari in spring crop seasons 2009 and 2010 were developed at the Cereal Crops Research Institute. All.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.16.1
- DOI:
- 10.4238/2013.January.16.1