Human Genetics
Acidic and basic fibroblast growth factor expression levels in cervical cancer and their effects on tumor cell proliferation
Authors: Q.H. Zhang, P. Xu, Y.X. Lu and H.T. Dou
Fibroblast growth factors (FGFs) play important roles in angiogenesis, wound healing, embryonic development, and endocrine signaling pathways. Increasingly, recent studies have reported aberrant FGF expression in various malignancies. However, the involvement of FGFs in cervical carcinoma pathogenesis remains unclear. We aimed.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049043
- DOI:
- 10.4238/gmr15049043
Absence of toxicity and genotoxicity in an extract of Rubus coriifolius
Authors: S. GonzÃ?¡lez-HernÃ?¡ndez, D. GonzÃ?¡lez-RamÃ?Ârez, M.I. DÃ?¡vila-RodrÃ?Âguez, A. Jimenez-Arellanez, M. Meckes-Fischer, S. Said-FernÃ?¡ndez and E.I. CortÃ?©s-GutiÃ?©rrez
Rubus coriifolius Focke is a wild plant from the Rosaceae family. It grows in both Guatemala and Mexico. The polar extract of the aerial parts of this plant has antibacterial, anti-inflammatory, and anti-protozoal activities. These properties may explain the traditional use of this plant. In vivo and in vitro assays were used .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048966
- DOI:
- 10.4238/gmr15048966
Reproductive outcome of male carriers of chromosomal abnormalities: multidisciplinary approach for genetic counseling and its implications
Authors: K.M. Guo, B. Wu, H.B. Wang and R.H. Tian
Chromosomal abnormality is the most common genetic cause of infertility. Infertility, as a psychological problem, has received an increasing amount of attention. Psychological interventions have been shown to have beneficial effects on infertile patients with chromosomal abnormalities. The present study explored reproductive o.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048963
- DOI:
- 10.4238/gmr15048963
Genetic association between ACTN3 polymorphism and risk of non-acute ankle sprain
Authors: B. Qi, J.Q. Liu and G.L. Liu
In this study, we investigated the association between ACTN3 R577X polymorphism and non-acute ankle sprain by measuring the allele frequency and genotype distribution of ACTN3 in a Chinese Han population. We recruited 100 patients with non-acute ankle sprain and 100 healthy controls with no history of ankle injuries. Mass spec.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048962
- DOI:
- 10.4238/gmr15048962
Genetic characteristics of non-Hodgkin lymphoma in ethnic Uighur people, and their clinical significance
Authors: L. Xu, X.G. Zou, X. Wang, A.B.L.M.T. Hairesa and J.J. Liu
The incidence of non-Hodgkin lymphoma (NHL) in China is increasing and is attracting attention as a topic of research. The percentage of NHL cases in ethnic Uighur people is also gradually increasing. We therefore recruited Uighur people with NHL to investigate the correlation between genetic alternations and clinical/patholog.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048960
- DOI:
- 10.4238/gmr15048960
Masking white spots of enamel in caries lesions with a non-invasive infiltration technique in vitro
Authors: X.-Y. Ou, Y.-H. Zhao, X.-K. Ci and L.-W. Zeng
We investigated the treatment effect of non-invasive infiltration on early caries caused by different degrees of enamel demineralization. Forty specimens of early enamel caries were prepared and divided into low and high demineralization groups. After treatment with non-invasive infiltration, the specimens were placed under ca.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.14
- DOI:
- 10.4238/2014.August.29.14
Hypoxia facilitates epithelial-mesenchymal transition-mediated rectal cancer progress
Authors: L.L. Sun, Z. Song, W.Z. Li and S.Y. Tang
Rectal cancer is a commonly observed tumor in clinics, and epithelial-mesenchymal transition (EMT) is very important for tumor invasion and metastasis. We established a rectal cancer HCT-116 cell hypoxia model and detected cell proliferation, invasion, and EMT-related protein expression in this model, aiming to analyze the eff.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048936
- DOI:
- 10.4238/gmr15048936
Parameters of a dynamic mechanistic model of cattle growth retain enough biological interpretation for genotype-to-phenotype mapping
Authors: M.C. Freua, M.H.A. Santana R.V. Ventura and J.B.S. Ferraz
This study aimed to investigate the predictability of a phenotype when using a dynamic model of cattle growth. Genotypic and phenotypic information on Nellore (Bos indicus) cattle were used in a genome-wide association analysis designed to contrast the biological interpretation of core parameters [conversion efficiency of meta.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048931
- DOI:
- 10.4238/gmr15048931
Immunological impression cytology of the conjunctival epithelium in patients with thyroid orbitopathy-related dry eye
Authors: S.L. Hsu, P.Y. Lee, C.H. Chang and C.H. Chen
Thyroid orbitopathy (TO) is an autoimmune disease that is complicated by ocular surface disorders, leading to discomfort. Dry eye is very prevalent in patients with TO. Recent studies on the pathogenesis of dry eye have focused on the inflammatory process, and some supporting evidence has been discovered. Because TO is a disor.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039011
- DOI:
- 10.4238/gmr.15039011
Matrix metalloproteinase gene polymorphisms and susceptibility to systemic sclerosis
Authors: T.F. Rech, S.B.C. Moraes, M. Bredemeier, J. de Paoli, J.C.T. Brenol, R.M. Xavier, J.A.B. Chies and D. Simon
The major pathological hallmark of the systemic sclerosis (SSc) is skin and internal organ fibrosis, which results from normal tissue architecture alterations and extracellular matrix (ECM) protein deposition. ECM components are degraded by matrix metalloproteinases (MMP). Promoter region polymorphisms in MMP genes may influen.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049077
- DOI:
- 10.4238/gmr15049077