Human Genetics
Study of the significance of iron deficiency indexes and erythrocyte parameters in anemic pregnant women and their newborns
Authors: L. Liu, Y. Xiao, B. Zou and L.L. Zhao
This study aimed to analyze the iron deficiency index and erythrocyte parameters in anemic pregnant women and their newborns, and explore their implications for anemia during pregnancy. Pregnant women (70) in the third trimester with hemoglobin (Hb) <100 g/L who registered and delivered from June 2012-2013 were randomly selected as the observation grou.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.14
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.14
Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis
Authors: G.-C. Shi and L.-G. Zhang
We conducted a case-control study in a Chinese population to examine the correlations between interleukin (IL)-17 gene polymorphisms and tuberculosis (TB) development. The study population included 336 TB subjects and 351 control subjects who were enrolled between June 2012 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.22
- DOI:
- 10.4238/2015.July.28.22
-173G/C polymorphism in the promoter of MIF is associated with hepatitis B virus infection in a Chinese Han population
Authors: Z.S. Wang, C.C. Yin, S. Han, F.L. Jiang, W.G. Guo, L.Q. Wu and S.H. Liu
In addition to the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. The macrophage migration inhibitory factor (MIF) -173G/C polymorphism (rs755622), located in the promoter region of MIF, may play integral roles in diverse processes, including the immune response. Thus, .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.23
- DOI:
- 10.4238/2015.July.28.23
RT-qPCR assay on the vitamin D receptor gene in type 2 diabetes and hypertension patients in Turkey
Authors: H.C. Vural1 and E. Maltas
RT-qPCR was used to analyze the vitamin D receptor (VDR) gene TaqI polymorphism in 100 Turkish patients with type 2 diabetes mellitus (T2DM) and hypertension compared with 100 healthy subjects, to determine whether VDR could be considered as one of the susceptibility genes for T2DM and hypertension. Genotyping was done with PC.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.14.1
- DOI:
- 10.4238/2012.March.14.1
Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis
Authors: M. Xiao, T. Wang, T. Zhu and F. Wen
Vitamin D-binding protein (DBP), a highly polymorphic serum protein, encoded by GC gene, is important in the development of chronic obstructive pulmonary disease (COPD). This meta-analysis was performed to assess the association between GC polymorphisms (1F, 1S, and 2 alleles) and COPD susceptibility. Published case-control studies were retrieved from the.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.1
Fibroblast growth factor receptor 4 Gly388Arg polymorphism associated with severity of gallstone disease in a Chinese population
Authors: Q. Chen, W.J. Li, Y.Y. Wan, C.D. Yu and W.G. Li
The etiology of gallstone disease is multifactorial; supersaturation of bile with cholesterol is a primary cause for gallstone formation. In previous studies, we found that fibroblast growth factor receptor 4 (FGFR4) plays an important role in maintaining bile acid homeostasis by regulating the expression of cholesterol 7&alph.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.8.3
- DOI:
- 10.4238/2012.March.8.3
Role of TGFB1 polymorphism in the development of metastatic brain tumors in non-small cell lung cancer patients
Authors: H.B. Wang, W.G. Song, H.Q. Liu, F. Fang and Y. Xiao
We conducted a case-control study to investigate the role of 3 single-nucleotide polymorphisms of the gene encoding transforming growth factor-b1 (TGFB1) in the development of metastatic brain tumors in non-small cell lung cancer patients. The polymorphisms in TGFB1 rs4803455, rs1800469, and rs1800470 were evaluated by polymerase chain reaction-restrictio.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.3
Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility
Authors: Z.-Q. Li, X.-P. Hu, , J.-Y. Zhou, X.-D. Xie and J.-M. Zhang
We investigated the role of 7 single nucleotide polymorphisms in the carbonic anhydrase (CA) VI gene (rs2274328, rs17032907, rs11576766, rs2274333, rs10864376, rs3765964, and rs6680186) and the possible association between these polymorphisms and dental caries susceptibility in a Northwestern Chinese population. We collected samples from 164 high caries e.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.16
- DOI:
- 10.4238/2015.June.1.16
Hemagglutinin protein of Asian strains of human influenza virus A H1N1 binds to sialic acid - a major component of human airway receptors
Authors: K.H. Chua and H.C. Chai
Hemagglutinin (HA) protein plays an important role in binding the influenza virus to infected cells and therefore mediates infection. Deposited HA sequences of 86 Asian strains of influenza A (H1N1) viruses during the first outbreak were obtained from the NCBI database and compared. Interaction of the HA protein of influenza A.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.16.1
- DOI:
- 10.4238/2012.March.16.1
Piperine inhibits cytokine production by human peripheral blood mononuclear cells
Authors: S. Chuchawankul, N. Khorana and Y. Poovorawan
Piperine, an amide isolated from Piper species (Piperaceae), has been reported to exhibit central nervous system depression, anti-pyretic and anti-inflammatory activity. Immunomodulatory and anti-tumor activity of piperine has been demonstrated in mouse carcinomas. However, there is little information available concerning the .. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.14.5
- DOI:
- 10.4238/2012.March.14.5