Human Genetics
Novel visual system homeobox 1 gene mutations in Turkish patients with keratoconus
Authors: H. Bardak, M. Gunay, E. Yildiz, Y. Bardak, B. Gunay, H. Ozbas and O. Bagci
The aim of this study was to screen the visual system homeobox 1 (VSX1) gene in Turkish patients with keratoconus (KC). The patient group consisted of 44 patients who had undergone corneal transplant surgery before the age of 30, for advanced and rapidly progressive KC. The control group comprised 250 healthy individuals. We d.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049024
- DOI:
- 10.4238/gmr15049024
Liguisticum wallichii inhibits renal carcinoma progression by downregulating UBE3A and through suppression of NF-�ºB signaling
Authors: J.S. Wu, P.M. Zhang, L.J. Sun and X.Z. Liu
Renal carcinoma accounts for a fifth of the morbidity among malignant tumors in China. Ubiquitin-protein ligase E3A (UBE3A) plays an important role in the occurrence and development of gene mutation-induced diseases. This study was designed to investigate the mechanism of Liguistium wallichii in treating renal carcinoma. Hemat.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049023
- DOI:
- 10.4238/gmr15049023
Cinnamon effectively inhibits the activity of leukemia stem cells
Authors: X. Guan, M.C. Su, R.B. Zhao, H.M. Ouyang, X.D. Dong, P. Hu, Q. Pei, J. Lu, Z.F. Li, C.R. Zhang and T.-H Yang
Cinnamon is the main component of Sanyangxuedai, which is one of the effective traditional Chinese medicines for treating malignancies. Leukemia is a prevalent malignant disease that Sanyangxuedai has been used to treat. Although successful in several studies, there is a lack of solid evidence as to why Sanyangxuedai has an effect on leukemia, and little .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037662
- DOI:
- 10.4238/gmr.15037662
Human leukocyte antigen-B27 alleles in Xinjiang Uygur patients with ankylosing spondylitis
Authors: H.-Y. Zou, W.-Z. Yu, Z. Wang, J. He and M. Jiao
We investigated the distribution of human leukocyte antigen (HLA)-B27 subtypes in Uygur ankylosing spondylitis patients in Xinjiang. B27-positive patients with ankylosing spondylitis were subtyped by using polymerase chain reaction-sequence-based typing. The HLA-B27 subtype frequencies of Uygur patients were compared with those in Han patients in Xinjiang.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.17
- DOI:
- 10.4238/2015.May.25.17
Effect of total peony glucoside pretreatment on NF-�ºB and ICAM-1 expression in myocardial tissue of rat with myocardial ischemia-reperfusion injury
Authors: L. Lu, P. Wei, Y. Cao, Q. Zhang, M. Liu, X.D. Liu, Z.L. Wang and P.Y. Zhang
Early recovery of myocardial perfusion is beneficial for myocardial ischemia. However, ischemia-reperfusion (I/R) may exacerbate myocardial injury. Research shows that total peony glucoside (TPG) can inhibit ischemic myocardial cell apoptosis. However, whether it can ameliorate I/R injury remains poorly understood. This study .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048978
- DOI:
- 10.4238/gmr15048978
Genetic diversity of Ceratoides arborescens, a species endemic to China, detected by intersimple sequence repeat (ISSR)
Authors: P.C. Wang, L.L. Zhao, B.T. Mo, Y. Zhang, J. Chen and L.B. Wang
In order to investigate genetic diversity and population structure of Ceratoides arborescens, six populations were selected from different steppe types in Inner Mongolia grasslands of China. Intersimple sequence repeat (ISSR) markers were used to assess the genetic diversity within and among natural populations of C. arborescens. Thirteen ISSR primers gen.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.18
- DOI:
- 10.4238/2015.May.25.18
Role of IL-8 gene polymorphisms in glioma development in a Chinese population
Authors: J.W. Fu, K.W. Wang and S.T. Qi
This case-control study aimed to investigate the role of -251 T>A (rs4073) and -781 C>T (rs2227306) polymorphisms in the interleukin-8 (IL-8) gene in the development of glioma in a Chinese population. One hundred and twenty-seven glioma patients and 284 healthy control subjects were recruited to this study between February 2013 and December 2014. Th.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038127
- DOI:
- 10.4238/gmr.15038127
Genetic ACE I/D and ACTN3 R577X polymorphisms and adolescent idiopathic scoliosis
Authors: R.P. Luciano, M. Wajchenberg, S.S. Almeida, C.E.N. Amorim, L.M.R. Rodrigues, R.C. Araujo, E.B. Puertas and F. Faloppa
The etiology of adolescent idiopathic scoliosis remains unknown. Angiotensin-converting enzyme and α-actinin-3 polymorphisms influence the characteristics of muscle fibers. The aim of this study was to examine the association between idiopathic scoliosis and genetic polymorphism of angiotensin-converting enzyme and &alph.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048959
- DOI:
- 10.4238/gmr15048959
Combination of IL-6, IL-10, and MCP-1 with traditional serum tumor markers in lung cancer diagnosis and prognosis
Authors: Y.W. Pan, Z.G. Zhou, M. Wang, J.Q. Dong, K.P. Du, S. Li, Y.L. Liu, P.J. Lv and J.B. Gao
Early detection and treatment is critically important for lung cancer patients. Inflammatory mediators such as IL-6, IL-10, and MCP-1 participate in lung cancer regulation. CEA, CA125, and ProGRP are commonly used serum tumor markers for lung cancer. In this study, we assessed the sensitivity and specificity of CEA, CA125, and.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048949
- DOI:
- 10.4238/gmr15048949
Identifying potential PARIS homologs in D. melanogaster
Authors: E.M. Merzetti and B.E. Staveley
Mitochondrial destruction leads to the formation of reactive oxygen species, increases cellular stress, causes apoptotic cell death, and involves a cascade of proteins including PARKIN, PINK1, and Mitofusin2. Mitochondrial biogenesis pathways depend upon the activity of the protein PGC-1α. These two processes are coordin.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048934
- DOI:
- 10.4238/gmr15048934