Human Genetics
Proliferation and differentiation of human osteoblasts from a type 2 diabetic patient in vitro
Authors: J. Li, C.Y. Liu, Y.F. Jiang, X.Z. Wei and J.U. Li
We investigated the proliferation and differentiation potential of human osteoblasts from a type 2 diabetic patient in vitro. Human osteoblasts were obtained from a healthy subject and a type 2 diabetic patient and were cultured in vitro using the tissue explant adherent method. Differences in cell morphology were observed under a phase contrast microscop.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.22.23
- DOI:
- http://dx.doi.org/10.4238/2015.September.22.23
Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population
Authors: Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population
The ubiquitin-conjugating enzyme 2B gene (UBE2B) is involved in the regular and symmetric organization of the fibrous sheath of sperm flagella. This study aimed to examine the relationship between single nucleotide polymorphisms (SNPs) in UBE2B and infertility in Northeast Chinese men. We carried out a polymerase chain reaction-restriction fragment length po.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.12.2
- DOI:
- 10.4238/2012.September.12.2
The role of ?±-satellite DNA and heterochromatin polymorphism in leukemia patients and illicit drug addicts
Authors: A. Movafagh, S.A. Mortazavi-Tabatabaei and A.A. Kolahi
Heterochromatin is considered to play a role in protecting the genome against mutagens. Changes in the quantity and proportion of different types of satellite DNA could increase genetic susceptibility in individuals with heterochromatic variations; they cause chromosome instability and predispose patients to malignancies. We e.. Read More»
- Genet. Mol. Res. 10(4):
- 2001.November.25.3
- DOI:
- 10.4238/2001.November.25.3
Increasing mutagenicity of S?£o Gon?§alo Channel waters based on the Allium cepa test
Authors: T.S. Paiva G.L. Garcias M.G. Martino-Roth
The São Gonçalo Channel is of great importance to the conservation of local biodiversity; it also is a water supply source of the city of Pelotas, Brazil, and the surrounding region. We examined the mutagenic activity of its waters. The following items were seasonally investigated in Allium cepa root radicular me.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr532
- DOI:
- 10.4238/vol8-1gmr532
Bovine papillomavirus DNA in milk, blood, urine, semen, and spermatozoa of bovine papillomavirus-infected animals
Authors: C.J. Lindsey M.E. Almeida C.F. Vicari C. Carvalho A. Yaguiu A.C. Freitas W. Be?§ak R.C. Stocco
Papillomavirus infection in bovines is associated with cutaneous papillomatosis on the hide, udders and other epithelial tissues, as well as in oral respiratory, alimentary and urinary tract mucosa. Bovine papillomavirus (BPV) is also considered the etiological agent of esophageal tumors and the malignant bladder tumors that c.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr573
- DOI:
- 10.4238/vol8-1gmr573
Distinction between plant samples according to allele dosage by semiquantitative polymerase chain reaction
Authors: F.A. Martins P.C.S. Carneiro C.T. Guimar?£es J.V. Magalh?£es J.E.S. Carneiro C.D. Cruz
The lack of informativity of samples from heterozygotic individuals is one of the hindrances in the mapping of quantitative trait loci of outbred populations, since it is not normally possible to identify the origin of each allele. One way to include these individuals in analyses would be to genotype their endosperm, consideri.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr585
- DOI:
- 10.4238/vol8-1gmr585
Antimutagenicity protection of Ginkgo biloba extract (Egb 761) against mitomycin C and cyclophosphamide in mouse bone marrow
Authors: J.B. Vilar K.R. Leite L. Chen Chen
Ginkgo biloba (Egb 761) extract, the most prescribed phytomedicine in Europe for the treatment of cerebral insufficiency and vascular diseases, was tested for its possible protective effects against mitomycin C (MMC)- and cyclophosphamide (CP)-induced mutagenicity using the micronucleus test in mouse bone marrow. The extract w.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr519
- DOI:
- 10.4238/vol8-1gmr519
Efficacy of Artemisia annua polysaccharides as an adjuvant to hepatitis C vaccination
Authors: L.D. Bao, X.H. Ren, R.L. Ma, Y. Wang, H.W. Yuan and H.J. Lv
The traditional Chinese medicine Artemisia annua can prevent and treat hepatitis following an unclear mechanism. The aim of this study was to evaluate the effects of A. annua polysaccharides (AAP) on hepatitis C virus (HCV). A pcDNA3.1/NS3 expression vector was constructed. Ninety female BALB/c mice were randomly divided into six groups: high-dose AAP (1 .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.29
- DOI:
- 10.4238/2015.May.11.29
Molecular and chromosomal mutations among children with B-lineage lymphoblastic leukemia in Brazilâ??s Federal District
Authors: D.R. Mesquita J.C. C?³rdoba ?.Q. Magalh?£es M.S. C?³rdoba J.R.C. Oliveira A. Gon?§alves I. Ferrari C. Martins-de-S?¡
Acute lymphoblastic leukemia (ALL) accounts for approximately 80% of all acute leukemias during childhood. Chromosomal anomalies resulting from gene fusion, which are frequent in leukemias, create hybrid transcripts, the great majority of which encode transcription factors. We analyzed 88 pediatric patients (median age 7.3 yea.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr582
- DOI:
- 10.4238/vol8-1gmr582
Tumor necrosis factor-like weak inducer of apoptosis association with proliferative diabetic retinopathy and promotes proliferation and collagen synthesis in retinal ARPE-19 cells
Authors: D.Y. Chen and G.F. Su
Chronic inflammation develops in the retinal microvasculature under sustained hyperglycemia and is implicated in the pathogenesis of diabetic retinopathy. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 have been reported to promote pro-inflammatory cytokines, which are involved in the pathogenesis of proliferative diabe.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016920
- DOI:
- 10.4238/gmr.15016920