Animal Genetics
A discriminative method for protein remote homology detection based on N-Gram
Authors: S. Xie, P. Li, Y. Jiang and Y. Zhao
Protein remote homology detection refers to detecting structural homology in proteins with an extremely low rate of sequence similarity. Such detection is primarily conducted using 3 methods: pairwise sequence comparisons, generative models for protein families, and discriminative classifiers. In this study, a discriminative classification method involvin.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.9
- DOI:
- 10.4238/2015.January.15.9
Manipulation of components that control feeding behavior in Drosophila melanogaster increases sensitivity to amino acid starvation
Authors: J.D. Slade and B.E. Staveley
Feeding is a complex behavior that is regulated by several internal mechanisms. Neuropeptides are able to survey quantities of stored energy and inform the organism if nutrient intake is required. In addition to this homeostatic regulation, a post-feeding reward system positively reinforces feeding. Slight adjustments to either system can tilt the balance.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017489
- DOI:
- 10.4238/gmr.15017489
Genome wide association study on early puberty in Bos indicus
Authors: A.V. Nascimento1, M.C. Matos2, L.O. Seno3, A.R.S. Romero1, J.F. Garcia4 andA.B. Grisolia1
The aim of this study was to evaluate a genome wide association study (GWAS) approach to identify single nucleotide polymorphisms (SNPs) associated with fertility traits (early puberty) in Nellore cattle (Bos indicus). Fifty-five Nellore cows were selected from a herd monitored for early puberty onset (positive pregnancy at 18 months of age). Extremes of .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017548
- DOI:
- 10.4238/gmr.15017548
Transfer and expression of the rabbit defensin NP-1 gene in lettuce (Lactuca sativa)
Authors: D. Song, X. Xiong, W.F. Tu, W. Yao, H.W. Liang, F.J. Chen and Z.Q. He
Lettuce (Lactuca sativa L.) is an annual plant of the daisy family, Asteraceae, with high food and medicinal value. However, the crop is susceptible to several viruses that are transmitted by aphids and is highly vulnerable to post-harvest diseases, as well as insect and mammal pests and fungal and bacterial diseases. Here, th.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019333
- DOI:
- 10.4238/gmr16019333
Molecular properties of the N-terminal extension of the fission yeast kinesin-5, Cut7
Authors: M. Edamatsu
Kinesin-5 plays an essential role in spindle formation and function, and serves as a potential target for anti-cancer drugs. The aim of this study was to elucidate the molecular properties of the N-terminal extension of the Schizosaccharomyces pombe kinesin-5, Cut7. This extension is rich in charged amino acids and predicted to be intrinsically disordered.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017799
- DOI:
- 10.4238/gmr.15017799
Involvement of ERK1/2 signaling in proliferation of eight liver cell types during hepatic regeneration in rats
Authors: X.G. Chen C.S. Xu Y.M. Liu
It has been well established that ERK1/2 signaling, often subdivided into nine types of pathways, can regulate the hepatocyte proliferative response during liver regeneration. However, the effect of ERK1/2 signaling on the proliferation of other hepatic cell types remains unclear. We isolated and purified 8 liver cell types at 10 time points after 2/3 hep.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.March.11.14
- DOI:
- 10.4238/2013.March.11.14
Application of 64-slice spiral computed tomography angiography in extremity vascular injuries
Authors: Y.B. Xia, G.M. Pan, C.J. Geng, F. Xue and Y.Y. Xie
The objective of the current study was to assess the utility of 64-row helical computed tomography angiography (CTA) in the evaluation of extremity vascular traumas. The extremities from 17 clinical cases of suspected traumatic vascular damage were evaluated using 64-row helical CTA. To evaluate extremity vascular traumas using CTA, volume rendering, mult.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.20
- DOI:
- 10.4238/2015.January.15.20
Isolation and molecular characterization of Leptospira borgpetersenii serovar Hardjo strain Hardjobovis in the urine of naturally infected cattle in Brazil
Authors: R.T. Chideroli1, U.P. Pereira2, D.D. Gon�§alves3, A.Y. Nakamura4, A.A. Alfieri5, A.F. Alfieri5 and J.C. Freitas1
Most epidemiologic studies on bovine leptospirosis are based on serological tests that use antibodies against several serotypes, including the serovar Hardjo, which is widespread and considered to be the most adapted to bovine hosts. However, using only serological studies is not sufficient to identify and distinguish species of leptospires. The aim of th.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15018473
- DOI:
- 10.4238/gmr.15018473
Study of biochemical changes in blood and various organs of Phrynops geoffroanus (Schweigger, 1812) (Testudines: Chelidae) collected in contaminated environment or exposed to benzo[a]pyrene
Authors: M.I.A. Silva, T.L. Silva and E.A. Almeida
The aquatic organisms are often exposed to a wide variety of chemicals, whose individual components are likely to produce different responses within the organisms and/or interact producing additive, synergistic or antagonistic toxic effects. Most of these substances are potentially cytotoxic, genotoxic or carcinogenic, such as polycyclic aromatic hydrocar.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15018568
- DOI:
- 10.4238/gmr.15018568
Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a Brazilian population
Authors: W.E.J.C. Mesquita, M.S. Approbato, K.K.V.O. Moura, and R.S.A. JesuÃ?Âno
The androgen receptor (AR) is a protein encoded by the AR gene, which when mutated may affect spermatogenesis, the process in which spermatozoa are produced; thus, AR mutations could lead to male infertility. We examined exon 1 of the AR gene in men with idiopathic infertility. Blood or semen samples from 111 infertile, oligoz.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr686
- DOI:
- 10.4238/vol8-4gmr686