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Animal Genetics   Research Article

Protective effect of Vitamin D on Cardiac Mitochondrial Apoptotic pathway in Rats fed with high fat diet

Authors: Khadeejah Mesaid Al-Solami, Zienab Alrefaie, Hossam Awad

Background: Both diet quality and vitamin D status are important factors associated with many cardiovascular risk factors. Cardiac mitochondrial pathway of apoptosis has been associated with those factors. The current work aimed to assess the effect of chronic consumption of high fat diet (HFD) on the cardiac markers of mitochondrial path.. Read More»

Genet. Mol. Res. 19(5):
Animal Genetics   Research Article

Potential Protective Effect of Vitamin D on Cardiac Extrinsic pathways of apoptosis in Male Rats Fed with high fat diet

Authors: Khadeejah Mesaid Al-Solami, Zainab Al-refaie, Hossam Awad, Mahmood Rasool

Background: Obesity and vitamin D deficiency are increasing in Kingdom of Saudi Arabia (KSA) in last decades. Researchers have shown a relation between both disorders and cardiovascular disease (CVD). The present work aimed to investigate the possible protective effect of vitamin D on cardiac apoptosis in rats fed with a high fat diet. Methods: This study.. Read More»

Genet. Mol. Res. 18(1):
Human Genetics   Research Article

Effect of 1,25(OH)2D3 on the proliferation of human mesangial cells and their expression of Ki67

Authors: D. Zhao, C.-J. Zhang, R. Yang, J.-P. Chen, L. Ma, G. Liu and X.-P. Yang

Previous studies have found that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3 or VD3] exerts many biological effects, including the inhibition of cell proliferation and induction of apoptosis, but its mechanism of action remains unclear. The goal of our investigation was to explore the effects of 1,25(OH)2D3 on the proliferation of c.. Read More»

Genet. Mol. Res. 16(2):
gmr16029191
DOI:
10.4238/gmr16029191
Human Genetics   Research Article

Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis

Authors: L.Wang, Z.T. Wang, J.J. Hu, R. Fan, J. Zhou and J. Zhong

The gene encoding vitamin D receptor (VDR) is recognized as a promising candidate for indicating the development of inflammatory bowel disease (IBD). Four genetic polymorphisms (ApaI, BsmI, FokI, TaqI) in VDR have been widely evaluated to determine their association with IBD, and the results of these evaluations are often inco.. Read More»

Genet. Mol. Res. 13(2):
2014.April.8.2
DOI:
10.4238/2014.April.8.2
Human Genetics   Research Article

Effect of early vitamin D supplementation on asthma and the possible mechanisms

Authors: X. Chen1, S.Q. Rao2, B.H. Gao3 and Z.Q. Jiang1

Asthma is a chronic inflammatory disease of the airways with variable airflow obstruction and bronchial hyper-responsiveness. It is believed that Th2-derived cytokines orchestrate the asthmatic response and the maintenance of the balance of Th1/Th2 plays a crucial role in prevention of asthma. Moreover, 1,25(OH)2D3, the biologically activate form of vitam.. Read More»

Genet. Mol. Res. 14(4):
2015.October.29.35
DOI:
10.4238/2015.October.29.35
Human Genetics   Research Article

Lack of association between the vitamin D receptor polymorphism rs2228570 and chronic periodontitis in a Han Chinese population

Authors: X. Wang, T.L. Zhang and D. Chen

The vitamin D receptor (VDR) is involved in the immune response and bone metabolism, both of which are implicated in the pathogenesis of chronic periodontitis (CP). In this study, we investigated the association between the VDR single nucleotide polymorphism rs2228570 and CP susceptibility in a Han Chinese population consistin.. Read More»

Genet. Mol. Res. 14(4):
2015.October.9.18
DOI:
10.4238/2015.October.9.18
Medical Genetics   Research Article

Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis

Authors: L.L. Zhang, J. Gong and C.T. Liu

Vitamin D deficiency and insufficiency are increasingly being recognized in the general population over the last few decades. However, a number of other disorders have now been linked to vitamin D deficiency and insufficiency, including asthma and COPD. The aim of this study was to evaluate the evidence on the effect of vitamin D on asthma and COPD. We se.. Read More»

Genet. Mol. Res. 13(3):
2014.February.13.10
DOI:
10.4238/2014.February.13.10
Human Genetics   Research Article

Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis

Authors: Y.L. Wang, H. Kong, W.P. Xie and H. Wang

Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the associ.. Read More»

Genet. Mol. Res. 14(3):
http://dx.doi.org/2015.September.9.16
DOI:
http://dx.doi.org/10.4238/2015.September.9.16
Medical Genetics   Research Article

Prevalence of vitamin D receptor gene polymorphism in a Uruguayan population and its relation to type 1 diabetes mellitus

Authors: Mimbacas A, Trujillo J, Gascue C, Javiel G and Cardoso H

Vitamin D has important immuno-modulatory properties and it influences insulin secretion. It acts through a vitamin D receptor (VDR), for which several gene polymorphisms have been described. The Uruguayan population presents several epidemiological characteristics that make it different from that of other counties, including .. Read More»

Genet. Mol. Res. 6(3):
Human Genetics   Research Article

Vitamin D receptor genetic variants are associated with susceptibility of gallbladder adenocarcinoma in a Chinese cohort

Authors: Z. Li, W.T. Yuan, S.J. Ning and S.J. Zhang

The aim of this study was to test for the possible association between vitamin D receptor (VDR) genetic variants and susceptibility to gallbladder cancer (GBC). A total of 291 GBC cases were recruited and 396 gender- and age-matched healthy volunteers were enrolled as controls. The VDR gene polymorphisms were determined in all.. Read More»

Genet. Mol. Res. 13(3):
2014.July.24.18
DOI:
10.4238/2014.July.24.18

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