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Lack of association of the G22A polymorphism of the ADA gene in patients with ankylosing spondylitis
Authors: U. Camargo, R.A. Toledo, J.R. Cintra, D.P.T. Nunes, R. Acayaba de Toledo, C.C. Brand�£o de Mattos and L.C. Mattos
Genes located outside the HLA region (6p21) have been considered as candidates for susceptibility to ankylosing spondylitis. We tested the hypothesis that the G22A polymorphism of the adenosine deaminase gene (ADA; 20q13.11) is associated with ankylosing spondylitis in 166 Brazilian subjects genotyped for the HLA*27 gene (47 p.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.7.3
- DOI:
- 10.4238/2012.May.7.3
Expression of MMP-1, -2, and -8 in longissimus dorsi muscle and their relationship with meat quality traits in cattle
Authors: Y.X. Qi, X.H. Zhang, Y.Q. Wang, Y.Z. Pang, Z.B. Zhang, T.L. Zhang andZ.X. Zhang
The extracellular matrix (ECM) is the major macromolecule in skeletal muscle, which affects meat quality greatly. The remodeling of the ECM is mainly regulated by matrix metalloproteinases (MMPs). The expression patterns of MMP-1, -2, and -8 in longissimus dorsi muscle were explored using quantitative real-time polymerase chain reaction. The results show .. Read More»
- Genet. Mol. Res. 14(1):
- gmr.15017593
- DOI:
- 10.4238/gmr.15017593
Effects of grafting on key photosynthetic enzymes and gene expression in the citrus cultivar Huangguogan
Authors: L. Liao1, S.Y. Cao1, Y. Rong1 and Z.H. Wang1,2
Grafting influences scion photosynthetic capacity and fruit quality. Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), which strongly affects photosynthetic rate, and Rubisco activase (RCA), which regulates Rubisco activity, are two key photosynthetic enzymes. However, little information is available regarding the effect of grafting on the concen.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017690
- DOI:
- 10.4238/gmr.15017690
Cloning and expression of class I chitinases in Hami melon after Penicillium infection
Authors: F.Y. Jiang, B.B. Shui, F.X. Tang and C.H. Shan
Chitinases are important disease-related proteins that play critical roles in plant defense against disease. To investigate the function of chitinases in the resistance of Hami melon to Penicillium infection, the gene encoding chitinases, HmCHT-2, was cloned and RT-PCR was used to measure expression levels of HmCHT-2. When the.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019085
- DOI:
- 10.4238/gmr16019085
Early selection of sugarcane using path analysis
Authors: R.P. Barbosa, F. Alc�¢ntara Neto, L.M. Gravina, G.A. Gravina, M.G.T. Portela and A.A.C. Bezerra
The aim of this study was to analyze sugarcane (Saccharum officinarum) biometric and technological data, obtained at different timepoints, using path analysis. The experiment was conducted in União, PI, Brazil, and evaluated 12 sugarcane genotypes (RB036066, RB9438, RB935744, RB021764, RB021754, RB021534, RB966229, RB97.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019038
- DOI:
- 10.4238/gmr16019038
Nested polymerase chain reaction technique for the detection of Gpc3 and Afp mRNA in liver cancer micrometastases
Authors: J. Luo, K. Yang and Y.G. Wen
The incidence of liver cancer has gradually risen to a high level in China, and tumor metastasis occurs via multiple pathways. Alpha fetal protein (AFP) is the main biomarker of liver cancer micrometastases. A recent study showed that glypican-3 (GPC3), which is abundant in hepatoma cells, has promising specificity and could b.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018947
- DOI:
- 10.4238/gmr16018947
Characterization of the inaA gene and expression of ice nucleation phenotype in Pantoea ananatis isolates from Maize White Spot disease
Authors: A.M. Miller1, J.E.F. Figueiredo3, G.A. Linde4, N.B. Colauto4and L.D. Paccola-Meirelles1,2,4
Maize White Spot (MWS), a foliar disease caused by Pantoea ananatis, could cause up to 60% yield loss. Some strains of P. ananatis harboring the ice nucleation gene inaA catalyze the formation of ice nuclei, causing tissue damage at temperatures slightly below freezing. Little is known about the relationship between the presence of the ina gene in this ma.. Read More»
- Genet. Mol. Res. 15(1):
- 0.4238/gmr.15017863
- DOI:
- 0.4238/gmr.15017863
ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be directly correlated with cardiovascular disease risk
Authors: N. Jiang, G. Yang and C.L. Peng
The aim of this meta-analysis was to evaluate the correlations between the estrogen receptor 1 (ESR1) gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) and the risk of cardiovascular disease (CVD). Case-control studies were screened and selected from a larger group of studies that were retrieved through a comprehensive search of scient.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.14
- DOI:
- 10.4238/2015.October.29.14
Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway
Authors: Z.G. Peng1, D.C. Liu2, Y.B. Yao1, X.L. Feng3, X. Huang1, Y.L. Tang1, J. Yang1 and X.X. Wang1
Paclitaxel (PTX) is a mitotic inhibitor widely used in chemotherapy for many types of cancers, including solid tumors and hematological malignancies. However, the molecular basis of the anti-proliferation activity of PTX is not fully understood. In this paper, we focused on the role of c-Jun N-terminal kinase (JNK) pathways in PTX-induced apoptosis and pr.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15013904
- DOI:
- 10.4238/gmr.15013904
SSR analysis demonstrates that olive production in the southern Marmara region in Turkey uses a single genotype
Authors: A. Ipek, E. Barut, H. Gulen, A.T. Oz, N.A. Tangu and M. Ipek
The southern Marmara region in Turkey was surveyed to determine the olive cultivars that are used for olive production. Genetic diversity analysis using simple sequence repeat (SSR) markers indicated that the cultivar Gemlik is the major olive cultivar grown in this region, while other olive cultivars are grown only for use as.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr659
- DOI:
- 10.4238/vol8-4gmr659