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Generation of a preliminary bovine gene atlas, using expression clustering to annotate gene function
Authors: O.M. Keane1,3, N. Maqbool2, A.F. McCulloch2, J.C. McEwan2 and K.G. Dodds2
Genes whose products function in a common biological process are often co-regulated. When regulation occurs at the transcriptional level, co-expressed genes can be detected globally by expression arrays or by sequencing non-normalized cDNA libraries. We examined bovine gene expression in 27 tissues using non-normalized cDNA library sequencing. Contigs wer.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr594
- DOI:
- 10.4238/vol8-3gmr594
Gene expressions levels of 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPase�² in gill tissue of Mugil cephalus acclimated to low salinity
Authors: L. Li, M. Jiang and X.Q. Shen
Fishes adapt to salinity changes primarily through osmotic pressure regulation, a process often associated with several genes, including 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPaseβ. The present study investigated the differential expression of genes 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPaseβ in the gill tissue of Mu.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019444
- DOI:
- 10.4238/gmr16019444
Inhibition of SHH pathway mechanisms by arsenic trioxide in pediatric medulloblastomas: a comprehensive literature review
Authors: P.H.S. Klinger, A.F. Andrade, L.E.A. Delsin, R.G.P. Queiroz, C.A. Scrideli, L.G. Tone and E.T. Valera
Recent innovations in the genomic understanding of medulloblastomas have provided new ways to explore this highly invasive malignant brain cancer arising from the cerebellum. Among the four different medulloblastoma subgroups described to date, the sonic hedgehog (SHH) genetic pathway is the pathway activated in the tumorigene.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019412
- DOI:
- 10.4238/gmr16019412
Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes
Authors: J. Zekri, A. Al-Shehri, M. Mahrous, S. Al-Rehaily, T. Darwish, S. Bassi, H. El Taani, A. Al Zahrani, S. Elsamany, J. Al-Maghrabi and B.B. Sadiq
Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019369
- DOI:
- 10.4238/gmr16019369
Path analysis of the energy density of wood in eucalyptus clones
Authors: A.M. Couto, P.E. Teodoro, P.F. Trugilho
Path analysis has been used for establishing selection criteria in genetic breeding programs for several crops. However, it has not been used in eucalyptus breeding programs yet. In the present study, we aimed to identify the wood technology traits that could be used as the criteria for direct and indirect selection of eucalyp.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019536
- DOI:
- 10.4238/gmr16019536
MicroRNA-139 modulates Alzheimer�s-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2
Authors: Y. Tang, J.S. Bao, J.H. Su and W. Huang
Alzheimer’s disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as we.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019166
- DOI:
- 10.4238/gmr16019166
IL-8 -251A/T polymorphism contributes to coronary artery disease susceptibility in a Chinese population
Authors: R.J. Zhang, X.D. Li, S.W. Zhang, X.H. Li and L. Wu
Interleukin-8 (IL-8) is a mediator of inflammation and plays an important role in regulating immune responses. To date, several studies have tested the association between IL-8 gene polymorphisms and development of coronary artery disease (CAD), but their results have proved to be inconsistent. We conducted an investigation to.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018224
- DOI:
- 10.4238/gmr16018224
Osteoblast differentiation of rabbit adipose-derived stem cells by polyethylenimine-mediated BMP-2 gene transfection in vitro
Authors: Q.F. Wang, Y. Huang, G.C. He, H.S. Wang, Z.H. Chen, X.H. Cai, Y.H. Xie and Q. Liu
The aim of this study was to examine the efficiency of polyethylenimine-mediated transfection of the human bone morphogenetic protein-2 (BMP-2) gene into rabbit adipose-derived stem cells (ADSCs), and its effect on osteoblast differentiation. Adipose tissue was isolated from the necks of adult Japanese white rabbits and cultur.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16015358
- DOI:
- 10.4238/gmr16015358
Genetic characterization of the mite Varroa destructor (Acari: Varroidae) collected from honey bees Apis mellifera (Hymenoptera, Apidae) in the State of Santa Catarina, Brazil
Authors: R. Strapazzon, F.E. Carneiro, J.C.V. Guerra Jr. and G. Moretto
The mite Varroa destructor is an ectoparasite that is considered a major pest for beekeeping with European honey bees. However, Africanized bee colonies are less threatened by this ectoparasite, because infestation levels remain low in these bees. The low reproductive ability of female mites of the Japanese biotype (J), introduced to Brazil early in .. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr567
- DOI:
- 10.4238/vol8-3gmr567
In vitro regeneration of cocona (Solanum sessiliflorum, Solanaceae) cultivars for commercial production
Authors: A.R. Schuelter1, A.K. Grunvald1, A.T. Amaral J�ºnior2, C.L. da Luz1,C.L. Luz1, L.M. Gon�§alves1, S. Stefanello1 and C.A. Scapim3
Cocona (Solanum sessiliflorum Dunal) is a solanaceous shrub native to the Amazon region that produces an edible fruit. This species has numerous advantages, particularly a high nutritional value and productivity. However, due to irregular germination and rapid loss of seed viability, there are few plantations for production on a large scale. Development o.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr613
- DOI:
- 10.4238/vol8-3gmr613