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Frequency of gray coat color in native Chinese horse breeds
Authors: K.X. Gao1, N.B. Chen1, W.J. Liu2, R. Li1, X.Y. Lan1, H. Chen1,C.Z. Lei1 and R.H. Dang1
Gray horses are born colored, and they then gradually lose their hair pigmentation. Tremendous progress has been made in identifying the genes responsible for graying with age in horses in recent years. Results show that gray coat color in horses is caused by a 4.6-kb duplication in intron 6 of the syntaxin 17 gene (STX17), which constitutes a cis-acting-.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.36
- DOI:
- 10.4238/2015.October.29.36
Lack of association between rare mutations of the SIAE gene and rheumatoid arthritis in a Han Chinese population
Authors: D.D. Zhang1,2*, F. He3*, H.T. Liu4*, F. Hao1 and J. Zhu5
The function of rare genotypes encoding defective variants of sialic acid acetylesterase (SIAE) in some autoimmune diseases, including rheumatoid arthritis (RA), is ambiguous. We determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population.DNA was prepared from the venous leukocytes of 444 RA patients and 647 normal con.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.38
- DOI:
- 10.4238/2015.October.29.38
Comparative study of neural differentiation of bone marrow mesenchymal stem cells by different induction methods
Authors: M.W. Mu, Z.Y. Zhao and C.G. Li
Neurogenic differentiation of bone marrow (BM) mesenchymal stem cells (MSCs) offers a new hope for patients with many neurological disorders. Several chemical inducers are employed to induce BMMSCs differentiation into nerve cells. In the present study, we compared different inducers [2-mercaptoethanol (BME), tretinoin (ATRA), dimethyl sulfoxide/butylated.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.39
- DOI:
- 10.4238/2015.October.29.39
Expression of Ras-related protein 25 predicts chemotherapy resistance and prognosis in advanced non-small cell lung cancer
Authors: Y.F. Ma*, B. Yang*, J. Li, T. Zhang, J.T. Guo, L. Chen, M. Li, J. Chu,C.Y. Liang and Y. Liu
Ras-related protein 25 (Rab25) is involved in many human malignancies. However, its role in chemotherapy response and prognosis in advanced non-small cell lung cancer (NSCLC) remains unknown. Therefore, we investigated the relationship between Rab25 and chemotherapy sensitivity and prognosis in NSCLC. Rab25 expression was assessed using immunohistochemist.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.19
- DOI:
- 10.4238/2015.October.29.19
15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation
Authors: X.Y. Li1,2, B.L. Luo1, L.J. Wang1, W.D. Zhang2 and Z.G. Liu2
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates antioxidant and anti-inflammatory genes, and it plays a crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Moreover, 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) plays a protective role against oxidative stress and inflammation bot.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.22
- DOI:
- 10.4238/2015.October.29.22
Analysis of regulatory T cell subsets in the peripheral blood of immunoglobulin A nephropathy (IgAN) patients
Authors: S. Yang, B. Chen, J. Shi, F. Chen, J. Zhang and Z. Sun
The aim of this study was to investigate the clinical significance of regulatory T cells (Tregs) and its subsets in immunoglobulin A nephropathy (IgAN) patients. Peripheral blood samples of 20 IgAN patients and 20 healthy individuals of similar ages were analyzed. Levels of Tregs and its subsets, namely nTregs and iTregs, were analyzed using flow cytometr.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.28
- DOI:
- 10.4238/2015.October.29.28
Pyridoxal 5�-phosphate-responsive epilepsy with novel mutations in the PNPO gene: a case report
Authors: M. Veeravigrom1,2, P. Damrongphol1,2, R. Ittiwut3,4, C. Ittiwut3,4,K. Suphapeetiporn3,4 and V. Shotelersuk3,4
Pyridoxal 5'-phosphate (PLP)-responsive epilepsy is a rare autosomal recessive epileptic disorder caused by deficiency of pyridox(am)-ne 5'-phosphate oxidase (PNPO). Neonatal onset seizures in PLP responsive epilepsy are usually resistant to common anticonvulsants and pyridoxine, but respond to PLP. Various PNPO mutations are associated with this disorder.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.34
- DOI:
- 10.4238/2015.October.29.34
Natural hybridization between Gossypium mustelinum and exotic allotetraploid cotton species
Authors: I.P.P. de Menezes1, J.O. da Silva1, G. Malafaia1, R.D.D. Silveira1 andP.A.V. Barroso2
Cotton has been collected in Brazil for decades for its conservation, evaluation, and the use of its genetic resources. Gossypium mustelinum is an allotetraploid cotton species that only occurs in Brazil, and little is known about its genetic potential for improvement. However, the species is threatened by habitat fragmentation and interspecific hybridiza.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.40
- DOI:
- 10.4238/2015.October.29.40
Screening potential SSR markers of the anadromous fish Coilia nasus by de novo transcriptome analysis using Illumina sequencing
Authors: D.-A. Fang1,2, Y.-F. Zhou2, J.-R. Duan2, M.-Y. Zhang2, D.-P. Xu2, K. Liu2, P. Xu1,2* and Q. Wei3*
RNA-Seq technology has been widely applied to transcriptomics, genomics, molecular marker development, and functional gene studies. In the genome, microsatellites are simple sequence repeats (SSR) with a high degree of polymorphism that are used as DNA markers in many molecular genetic studies. Using traditional methods such as magnetic bead enr.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.1
- DOI:
- 10.4238/2015.November.13.1
Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model
Authors: X.Q. Chu1*, J.J. Wang2*, L.D. Dou1 and G. Zhao1
The main pathological characteristic of osteoarthritis (OA) is cartilage damage. We explored cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3) changes during articular cartilage injury and repair. Rabbits were randomly divided into the following: a blank control group; groups M1, M2, and M3, in which breaking was performed .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.4
- DOI:
- 10.4238/2015.November.13.4