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Multiple sequence alignment based on combining genetic algorithm with chaotic sequences
Authors: C. Gao, B. Wang, C.J. Zhou and Q. Zhang
In bioinformatics, sequence alignment is one of the most common problems. Multiple sequence alignment is an NP (nondeterministic polynomial time) problem, which requires further study and exploration. The chaos optimization algorithm is a type of chaos theory, and a procedure for combining the genetic algorithm (GA), which use.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028788
- DOI:
- 10.4238/gmr.15028788
Identification of genes associated with the increased number of four-seed pods in soybean (Glycine max L.) using transcriptome analysis
Authors: Z.Z. Liu, D. Yao, J. Zhang, Z.L. Li, J. Ma, S.Y. Liu, J. Qu, S.Y. Guan, D.D. Wang, L.D. Pan, D. Wang and P.W. Wang
Seed number per pod is an important component of yield traits in soybean (Glycine max L.). In 2010, we identified a natural mutant with an increased number of four-seed pods from a soybean variety named ‘Jinong 18’ (JN18). Subsequent observations indicated that the trait was stably inherited. To identify and understand the function of genes as.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.39
- DOI:
- 10.4238/2015.December.28.39
Comparative transcriptome analysis of testes and ovaries for the discovery of novel genes from Amur sturgeon (Acipenser schrenckii)
Authors: S.B. Jin, Y. Zhang, X.L. Dong, Q.K. Xi, D. Song, H.T. Fu and D.J. Sun
Sturgeons (Acipenser schrenckii) are of high evolutionary, economic, and conservation value, and caviar isone of the most valuable animal food products in the world. The Illumina HiSeq2000 sequencing platform was used to construct testicular and ovarian transcriptomes to identify genes involved in reproduction and sex determination in A. schrenckii. A tot.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.40
- DOI:
- 10.4238/2015.December.28.40
Mechanism underlying the bio-effects of an electromagnetic field based on the Huang-Ferrell model
Authors: D.Y. Geng, G. Hu, L. Wang, N. Jia and F.X. Wang
To understand the beneficial and harmful bio-effects of extremely low frequency electromagnetic fields, we studied the MAPK/ERK signaling pathway based on the Huang-Ferrell model. The sensitivity analysis method was used to study the influence of the model parameters on the activity of ERK, and to further investigate the key b.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028796
- DOI:
- 10.4238/gmr.15028796
Genetic characterization of red-colored heartwood genotypes of Chinese fir using simple sequence repeat (SSR) markers
Authors: H.J. Duan, R.Y. Hu, B. Wu, D.X. Chen, K.Y. Huang, J. Dai, Q. Chen, Z.C. Wei, S. Cao, Y.H. Sun and Y. Li
The present study investigated the genetic characterization of red-colored heartwood Chinese fir [Cunninghamia lanceolata (Lamb.) Hook.] in Guangxi using 21 simple sequence repeat (SSR) markers and analyzes of the genetic variation (N = 149) in samples obtained from five sites in Guangxi Province, China. The number of different alleles and the Shannon&rsq.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.2
- DOI:
- 10.4238/2015.December.28.2
Applying the Fisher score to identify Alzheimer�s disease-related genes
Authors: J. Yang, Y.L. Liu, C.S. Feng and G.Q. Zhu
Biologists and scientists can use the data from Alzheimer's disease (AD) gene expression microarrays to mine AD disease-related genes. Because of disadvantages such as small sample sizes, high dimensionality, and a high level of noise, it is difficult to obtain accurate and meaningful biological information from gene expressio.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028798
- DOI:
- 10.4238/gmr.15028798
A simple real-time polymerase chain reaction (PCR)-based assay for authentication of the Chinese Panax ginseng cultivar Damaya from a local ginseng population
Authors: H. Wang, J. Wang2 and G. Li
Panax ginseng is one of the most important medicinal plants in the Orient. Owing to its increasing demand in the world market, cultivated ginseng has become the main source of medicinal material. Among the Chinese ginseng cultivars, Damaya commands higher prices and is grown in significant proportions among the local ginseng p.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028801
- DOI:
- 10.4238/gmr.15028801
Expression profiles of MMP-1 and TIMP-1 in lumbar intervertebral disc degeneration
Authors: B. Deng, J.Z. Ren, X.Q. Meng, C.G. Pang, G.Q. Duan, J.X. Zhang, H. Zou, H.Z. Yang and J.J. Ji
Lumbar intervertebral disc degeneration (IDD) is a common clinical pathology and has become a focus for research in recent years. Matrix metalloproteinases (MMPs) are enzymes responsible for the degradation of almost all extracellular matrix proteins (ECM). The over-expression of MMPs or tissue inhibitors of metalloproteinases (TIMPs) may disrupt the dyna.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.16
- DOI:
- 10.4238/2015.December.29.16
Levels of mannose-binding lectin in individuals with visceral leishmaniasis in the northeast region of Brazil
Authors: E.L. da Silva, M. Campos J�ºnior, S.G. Monteiro, G.C. Costa, A.L.P. Magalh�£es, M.D.C. Santos, A.J.M. Caldas and M.M.G. Pimentel
Visceral leishmaniasis (VL) is one of the seven priority endemic diseases in the world. The clinical outcome of many infections is not only dependent on the pathogenic organism, but also on the genetic variability of the host susceptibility to infection. Mannose-binding lectin (MBL) is a protein that plays an important role in the innate immune system. Th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.18
- DOI:
- 10.4238/2015.December.29.18
Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population
Authors: Y. Yang, J.R. Xu, Y.J. Wang and X.M. Li
Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui popula.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.13
- DOI:
- 10.4238/2015.August.21.13