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Telomere-associated factor expression in replicative senescence of human embryonic lung fibroblasts
Authors: H. Du, L. Yang, X.-Y. Xu, L. Hai, Y.-Q. Han and Y.-X. Shi
The objective of this study was to find the key regulatory molecules in the cell senescence process through observing the expression of telomere-associated factor during the normal cell replicative senescence process. Based on the established cell replicative senescence model, reverse transcription-polymerase chain reaction and western blot analyses were .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.7
- DOI:
- 10.4238/2015.August.10.7
Ectopic expression of the BoTFL1-like gene of Bambusa oldhamii delays blossoming in Arabidopsis thaliana and rescues the tfl1 mutant phenotype
Authors: H.Y. Zeng, Y.T. Lu, X.M. Yang, Y.H. Xu and X.C. Lin
TERMINAL FLOWER1 (TFL1) homologous genes play major roles in maintaining vegetative growth and inflorescence meristem characteristics in various plant species; however, to date, the function of the bamboo TFL1 homologous gene has not been described. In this study, a TFL1 homologous gene was isolated from Bambusa oldhamii and designated as BoTFL1-like. Phy.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.11
- DOI:
- 10.4238/2015.August.10.11
Effect of phosphatidylserine on memory in patients and rats with Alzheimer�s disease
Authors: Y.Y. Zhang, L.Q. Yang and L.M. Guo
The aim of this study was to investigate the effect of phosphatidylserine (PS) on memory of patients and rats with Alzheimer’s disease (AD). In total, 57 AD patients were recruited from our hospital, and were divided into two groups: 25 in the control group and 32 in the observation group. Next, 300 mg/d of PS was given to the rats in the observatio.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.13
- DOI:
- 10.4238/2015.August.10.13
Novel exon nucleotide deletion causes adrenoleukodystrophy in a Brazilian family
Authors: E.R. Valadares*, A.L.C. Trindade*, L.R. Oliveira, R.R. Arantes, M.V. Daker, B.M. Viana, V.G. Haase, L.B. Jardim, G.C. Lopes and A.L.B. Godard
Adrenoleukodystrophy is a neurodegenerative X-linked recessive disorder. It is characterized by abnormal function of peroxisomes, which leads to an accumulation of very long-chain fatty acids in plasma and tissues, especially in the cortex of adrenal glands and white matter of the central nervous system, causing demyelinating .. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr975
- DOI:
- 10.4238/vol10-1gmr975
Allelic polymorphism, gene duplication and balancing selection of the MHC class II DAB gene of Cynoglossus semilaevis (Cynoglossidae)
Authors: T.J. Xu*, Y.N. Sun* and R.X. Wang
Major histocompatibility complex (MHC) genes play an important role in the immune response of vertebrates. Allelic polymorphism and evolutionary mechanism of MHC genes have been investigated in many mammals, but much less is known in teleosts. We examined the polymorphism, gene duplication and balancing selection of the MHC cl.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr960
- DOI:
- 10.4238/vol10-1gmr960
Cloning and transformation analysis of isoflavone synthase gene into Minshan Trifolium pratense
Authors: H.H. Hu, C.Q. Jing, R. Liu, W.D. Li and H.G. Feng
The aim of this study was to clone the isoflavone synthase (IFS) gene and establish the recombinant Minshan Trifolium pratense. The IFS gene was cloned from the callus of Minshan T. pratense using reverse transcription-polymerase chain reaction. The plant expression vector pRI101-AN-IFS was constructed and introduced into Agrobacterium tumefaciens strain .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.9
- DOI:
- 10.4238/2015.August.10.9
New compound heterozygous mutations of p. Thr101Ilefs*2 and p. Thr306Ale in a child from a Chinese family with 17�±-hydroxylase/17, 20-lyase deficiency
Authors: H. Xiao, H. Zhang, T. Li, D. Wu, L.T. Qin, T. Wang, B. Zhang and S.X. Liao
We determined whether a child with 17a-hydroxylase/17, 20-lyase deficiency possessed the sex-determining region (SRY) gene, and examined the mutations present in the CYP17A1 gene that led to 17a-hydroxylase/17, 20-lyase deficiency. In the child, karyotype analysis was performed and polymerase chain reaction analysis and electrophoretic techniques were use.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.12
- DOI:
- 10.4238/2015.August.10.12
Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with ischemic stroke in the Eastern Chinese Han population
Authors: Q.-Q. Lv,J. Lu,H. Sun and J.-S. Zhang
The association between the MTHFR genetic polymorphism and ischemic stroke has been reported by a number of investigators. However, the results have been controversial and conflicting. The aim of this study was to explore the association between the MTHFR variants C677T and A1298C and the risk of ischemic stroke in an Eastern Chinese Han population. A tot.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.31
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.31
Genetic variation of Casuarina equisetifolia subsp equisetifolia and C. equisetifolia subsp incana populations on the northern coast of Senegal
Authors: A.L. Ndoye, O. Sadio and D. Diouf
The genetic variation of 70 individual samples of Casuarina equisetifolia (L. Johnson) subsp equisetifolia and C. equisetifolia subsp incana growing along the northern coast of Senegal was analyzed with RAPD markers. Of the 160 primers tested, five were chosen; they generated 1396 reproducible bands and 61 polymorphic bands th.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr986
- DOI:
- 10.4238/vol10-1gmr986
Overexpression of EsMcsu1 from the halophytic plant Eutrema salsugineum promotes abscisic acid biosynthesis and increases drought resistance in alfalfa (Medicago sativa L.)
Authors: C. Zhou, Z.Y. Ma, L. Zhu, J.S. Guo, J. Zhu and J.F. Wang
The stress phytohormone abscisic acid (ABA) plays pivotal roles in plants’ adaptive responses to adverse environments. Molybdenum cofactor sulfurases influence aldehyde oxidase activity and ABA biosynthesis. In this study, we isolated a novel EsMcsu1 gene encoding a molybdenum cofactor sulfurase from Eutrema salsugineum. EsMcus1 transcriptional patt.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.20
- DOI:
- 10.4238/2015.December.16.20