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R337H mutation of the TP53 gene as a clinical marker in cancer patients: a systematic review of literature
Authors: L.M. Borges and F.M. Ayres
The germline R337H mutation of the TP53 gene has been associated with the development of many tumor types. This systematic review of literature investigated the association between the R337H mutation and the patients’ family history and its predictive and prognostic value in cancer. Data were collected from articles archived in the PubMed, LILACS, M.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.4
- DOI:
- 10.4238/2015.December.16.4
Interaction between ALOX5AP-SG13S114A/T and COX-2-765G/C increases susceptibility to cerebral infarction in a Chinese population
Authors: X.Y. Yi, Q. Zhou, J. Lin, L.F. Chi and W.Z. Chi
We made a case-control study to investigate a possible association between ALOX5AP-SG13S114A/T, COX-2-765G/C, and COX-1-50C/T polymorphisms with cerebral infarction in a Chinese population. A total of 411 cases with cerebral infarction were included; 411 controls matched for age, gender, and risk factors were also selected. The ALOX5AP-SG13S114A/T (rs1050.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.6
- DOI:
- 10.4238/2013.May.14.6
Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis
Authors: J.W. Gao, K.F. Zhang, J.S. Lu and T. Su
Cumulated evidence indicates that matrix metalloproteinase-3 (MMP-3) is significantly involved in cancer progression. Recent studies yielded conflicting results regarding the association between serum MMP-3 and ankylosing spondylitis (AS). To clarify this correlation, we performed a meta-analysis. Potential relevant studies were identified by searching th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.7
- DOI:
- 10.4238/2015.December.16.7
Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population
Authors: S.H. Ma, F.H. Ling, Y.X. Sun, S.F. Chen and Z. Li
We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028066
- DOI:
- 10.4238/gmr.15028066
Expression of Magnaporthe oryzae genes encoding cysteine-rich proteins secreted during nitrogen starvation and interaction with its host, Oryza sativa
Authors: J. Yang, M.L. Liang, J.L. Yan, Y.Q. Yang, L. Liu, C. Liu, L.J. Yang and C.Y. Li
Previous studies have shown that the blast fungus, Magnaporthe oryzae, may experience nitrogen starvation during infection of its plant host (rice,Oryza sativa). Here, we studied the expression of seven genes encoding cysteine-rich proteins with N-terminal signal peptides during nitrogen limitation and throughout the infection process. Some genes were upr.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.10
- DOI:
- 10.4238/2015.December.16.10
Overexpression of pucC improves the heterologous protein expression level in a Rhodobacter sphaeroides expression system
Authors: L. Cheng,G. Chen,G. Ding,Z. Zhao,T. Dong and Z. Hu
The Rhodobacter sphaeroides system has been used to express membrane proteins. However, its low yield has substantially limited its application. In order to promote the protein expression capability of this system, the pucC gene, which plays a crucial role in assembling the R. sphaeroides light-harvesting 2 complex (LH2), was overexpressed. To build a puc.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.21
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.21
Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy
Authors: M.M. Silva, C.O. Da Fonseca, R. Moura-Neto, J.F. Carvalho, T. Quirico-Santos and M.G. Carvalho
GSTM1 (glutathione S-transferase mu 1) and GSTT1 (glutathione S-transferase theta 1) are critical enzymes for detoxification of endogenous and environmental carcinogens. Constitutive GST gene polymorphisms may be associated with increased risk for cancer development. We made an explorative study of a Brazilian population with malignant glioma to determine.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.2
- DOI:
- 10.4238/2013.May.14.2
A new repertoire of informations about the quorum sensing system in Salmonella enterica serovar Enteritidis PT4
Authors: M.E.M. Campos-Galv�£o,T.D.S. Leite,A.O.B. Ribon,E.F. Ara�ºjo and M.C.D. Vanetti
Salmonella spp are among the main causative agents of foodborne diseases. Some phenotypes associated with increased drug resistance and virulence are regulated by quorum sensing (QS). In the present study, the autoinducer (AI)-1- and -2-mediated QS mechanisms were characterized in Salmonella enterica serovar Enteritidis PT4 for the first time. Salmonella .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.22
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.22
Correspondence between performance of Eucalyptus spp trees selected from family and clonal tests
Authors: C.A.F. Reis, F.M.A. Gon�§alves, L.N. Rosse, R.R.G.F. Costa and M.A.P. Ramalho
We examined the correspondence in performance between trees selected from a family test and their respective clones from a clonal test of Eucalyptus. Full-sib families were obtained from controlled pollination among individuals of Eucalyptus grandis and between E. grandis and E. urophylla. The hybridizations did not follow a f.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1078
- DOI:
- 10.4238/vol10-2gmr1078
3'-UTR polymorphism (rs10434) in the VEGF gene is associated with B-CLL in a Chinese population
Authors: L.X. Zhu,X.J. Ye,Y.G. Wang,J.J. Zhu, W.Z. Xie,Y.M. Zhao and X.Y. Lai
We investigated the relationship between a VEGF genetic polymorphism and B cell chronic lymphocytic leukemia (B-CLL). A total of 102 patients with B-CLL and 124 healthy subjects were included in this study. All individuals were typed for the rs10434 in the vascular endothelial growth factor (VEGF) gene using the TaqMan technique. We found that the A allel.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.23
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.23