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IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease
Authors: L. Li, E. Li, L.H. Zhang, L.G. Jian, H.P. Liu and T. Wang
We conducted this case-control study to investigate the genetic role of IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T in the development of coronary artery disease (CAD) in a Chinese population. Polymorphisms IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T were determined by polymerase chain re.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.12
- DOI:
- 10.4238/2015.July.28.12
Proapoptotic effects of heme oxygenase-1 inhibitor on Kasumi-1 cells via the ATF4/ CHOP/Ire-1�± pathway
Authors: S.-X. Wei, Y.-T. Wang, Q.-X. Chai, Q. Fang, Y.-M. Zhang and J.-S. Wang
We evaluated the effects of down-regulated heme oxygenase (HO)-1 expression on the proliferation of the acute myelocytic leukemia Kasumi-1 cell line by using the HO-1 inhibitor zinc protoporphyrin IX (ZnPPIX) in combination with daunorubicin (DNR), and evaluated the mechanism. The proliferation rates of cells treated with 10 mg/mL DNR and 10 mM ZnPPIX ind.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.17
- DOI:
- 10.4238/2015.June.1.17
Isolation and characterization of microsatellite markers of sea cucumber Stichopus horrens
Authors: Z.B. Li, G. Dai, J.B. Shangguan, Y.F. Ning, Y.Y. Li, R.B. Chen, Y. Yuan and Y.S. Huang
Curry fish (Stichopus horrens) is a tropical holothurian species and is widely distributed in the India-West Pacific. In the present study, 9 polymorphic microsatellite loci were isolated and characterized for S. horrens. These loci were tested in 30 individuals from Hainan Island in China. The number of alleles ranged from 2 to 5. The polymorphism inform.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.18
- DOI:
- 10.4238/2015.July.28.18
Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis
Authors: X.M. Xie, R. Ke, Y.H. Zhang, G.Z. Wang, Y.T. Zhu, T. Hussian, L. Yang and M.X. Li
Association studies of interleukin-6 (IL-6) -174G>C polymorphism and chronic obstructive pulmonary disease (COPD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. A comprehensive search was performed in the PubMed, Embase, Elsevier, Web of Science databases, Wanfang, and the Chinese National Kn.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.21
- DOI:
- 10.4238/2015.July.28.21
Molecular cloning and bioinformatic analysis of the Streptococcus agalactiae neuA gene isolated from tilapia
Authors: E.L. Wang, K.Y. Wang, D.F. Chen, Y. Geng, L.Y. Huang, J. Wangand Y. He
Cytidine monophosphate (CMP) N-acetylneuraminic acid (NeuNAc) synthetase, which is encoded by the neuA gene, can catalyze the activation of sialic acid with CMP, and plays an important role in Streptococcus agalactiae infection pathogenesis. To study the structure and function of the S. agalactiae neuA gene, we isolated it from diseased tilapia, amplified.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.18
- DOI:
- 10.4238/2015.June.1.18
Effect of Xin Mai Jia on atherosclerosis in rats
Authors: P. Li, G.P. Pan, M. Jia, Q.Q. Wang, Z.G. Guo, F.R. Zhao, G.L. Lei, G.R. Wan and G.M. Wan
We investigated the therapeutic effect of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rats. Rat models of AS were established by peritoneally injecting vitamin D, feeding a high-fat diet, and inducing balloon injuries in rats. The stomachs of the rats were irrigated continuously for 10 weeks with XMJ. Blood lipid- and hemorheologyrelated indices of blood.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.19
- DOI:
- 10.4238/2015.June.1.19
Effect of bone marrow mesenchymal stem cells on the TGF-�²1/Smad signaling pathway of hepatic stellate
Authors: X.E. Sun, X.Q. Zhang and M.M. Liu
This study investigated the effect of bone marrow mesenchymal stem cells (BMCs) on the transforming growth factor-β1 (TGF-b1)-induced activation of the Smad signaling pathway in rat hepatic stellate cells (HSCs). There were four experimental groups: 1) a blank control group, 2) a TGF-b1 treatment group, 3) an MSC-combined group, and 4) an induced MSC.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.23
- DOI:
- 10.4238/2015.July.31.23
Integrated miRNA-mRNA analysis of Epstein-Barr virus-positive nasopharyngeal carcinoma
Authors: L.H. Zhu, X.T. Miao and N.Y. Wang
This study aims to identify the crucial miRNAs in Epstein-Barr virus-positive nasopharyngeal carcinoma (NPC) and their target genes. Gene expression profile data (GSE12452) that included 31 NPC and 10 normal nasopharyngeal tissue specimens were downloaded. Differentially expressed genes (DEGs) were identified using significance analysis of microarrays. Th.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.20
- DOI:
- 10.4238/2015.June.1.20
Identification of differentially expressed genes involved in early bolting of Angelica sinensis (Apiaceae)
Authors: G. Yu, Y.X. Ma, J.-A. Duan, B.S. Song and Z.Q. He
Angelica sinensis is a highly valued medicinal herb, known as female ginseng that is widely cultivated in China. Although A. sinensis is in great demand due to its multiple medicinal and food applications, its early bolting rate (almost 40%) seriously affects crop quality. To better understand its flowering mechanism, cDNA-amp.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.6.2
- DOI:
- 10.4238/2012.March.6.2
Polymorphisms in different EST-SSR types derived from the Chinese bayberry (Myrica rubra, Myricaceae) transcriptome
Authors: S.Y. Zhang, C. Feng, C.J. Xu, C.Q. Zhu and K.S. Chen
Most plant expressed sequence tag-simple sequence repeats (EST-SSRs) are not polymorphic, and it is important to learn the characteristics of highly polymorphic EST-SSRs. In this study, 357 compound and 5557 non-compound EST-SSRs, identified from the transcriptome of the Chinese bayberry (Myrica rubra ‘Biqi’), were divided into 11 types based .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.21
- DOI:
- 10.4238/2015.June.1.21