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Oxidative stress response in Paracoccidioides brasiliensis
Authors: Ã?Â?lida G. Campos, RosÃ?¡lia Santos Amorim Jesuino, Alessandra da Silva Dantas, Marcelo de Macedo BrÃ?Âgido and Maria Sueli S. Felipe
Survival of pathogenic fungi inside human hosts depends on evasion from the host immune system and adaptation to the host environment. Among different insults that Paracoccidioides brasiliensis has to handle are reactive oxygen and nitrogen species produced by the human host cells, and by its own metabolism. Knowing how the pa.. Read More»
- Genet. Mol. Res. 4(2):
Transporters in the Paracoccidioides brasiliensis transcriptome: insights on drug resistance
Authors: Christiane da Silva Costa, Fl�¡via Caixeta Albuquerque, Ros�¢ngela Vieira Andrade, Gina Camilo de Oliveira, Mauro Fernandes de Almeida, Marcelo de Macedo Brigido and Andrea Queiroz Maranh�£o
In the struggle for life, the capacity of microorganisms to synthesize and secrete toxic compounds (inhibiting competitors) plays an important role in successful survival of these species. This ability must come together with the capability of being unaffected by these same compounds. Several mechanisms are thought to avoid th.. Read More»
- Genet. Mol. Res. 4(2):
Effects of ACE polymorphisms and other risk factors on the severity of coronary artery disease
Authors: A.I. Guney, D. Ergec, D. Kirac, H. Ozturhan, M. Caner, G. Koc, C. Kaspar, K. Ulucan and M. Agirbasli
Coronary artery disease (CAD) is a multifactorial disease influenced by genetic and environmental factors. Major risk factors of CAD are hypertension, hyperlipidemia, smoking, family history and obesity. Also polymorphisms in the angiotensin-I converting enzyme (ACE) gene can associate with CAD. The relationship between ACE polymorphisms and other risk fa.. Read More»
- Genet. Mol. Res. 12(4):
- 2013
- DOI:
- 10.4238/2013
Transcriptome overview of Paracoccidioides brasiliensis proteases
Authors: Juliana Alves Parente, Milce Costa, Maristela Pereira and C�©lia Maria de Almeida Soares
Proteases perform a wide variety of functions inside and outside cells, regulating many biological processes. Infectious microorganisms use proteases, either secreted or attached to their cell surface to weaken and invade their hosts. Therefore, proteases are targets for drugs against a diverse set of diseases. Paracoccidioide.. Read More»
- Genet. Mol. Res. 4(2):
Development of polymorphic microsatellites for Sillago sihama based on next-generation sequencing and transferability to Sillago japonica
Authors: R.X. Wu, H.R. Zhang, S.F. Niu, Y. Zhai and X.F. Liu
Sillago sihama (Forsskål, 1775), a commercially important marine fishery species in the Indo-West Pacific, is being developed as a target species for aquaculture and stock enhancement in China. However, due to the limitations of traditional isolation methods, the available microsatellite loci, or simple sequence repeats .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049046
- DOI:
- 10.4238/gmr15049046
Analysis of intervertebral disc-related genes
Authors: D.J. Wu, K. Chen, X.Z. Wei, H.J. Ni, S.Z. Yu, X.D. Zhu and M. Li
Intervertebral disk disease is a common clinical disorder manifested by pain, ataxia, paresis, motor paralysis, and sensorimotor paralysis. The clinical features, diagnosis, and treatment of cervical and thoracolumbar disk disease have been unclear until now. In this study, some differentially expressed genes were identified, .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.24.7
- DOI:
- 10.4238/2014.March.24.7
Chromosomal characteristics and karyotype evolution of Oxyopidae spiders (Araneae, Entelegynae)
Authors: L.M. St�¡vale, M.C. Schneider, A.D. Brescovit and D.M. Cella
We made a cytogenetic analysis of four species of Oxyopidae and compared it with the karyotype data of all species of this family. In Hamataliwa sp, the mitotic cells showed 2nâÃ?Â?Ã?Â? = 26+X1X2 and telocentric chromosomes. The 2nâÃ?Â?Ã?Â? = 28, which has been described for only one oxyopid spider, is the highest .. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1084
- DOI:
- 10.4238/vol10-2gmr1084
Polymorphic microsatellite loci for the Japanese anchovy Engraulis japonicus (Engraulidae)
Authors: L. Lin, L. Zhu, S.-F. Liu, Y.-Q. Su and Z.-M. Zhuang
We isolated and characterized 14 polymorphic microsatellite loci in the Japanese anchovy (Engraulis japonicus) using a (GT)13-enriched genomic library. The numbers of alleles per locus ranged from 6 to 31, with a mean of 17.8. The observed and expected heterozygosities ranged from 0.180 to 0.949 and from 0.172 to 0.966, with means of 0.731 and 0.825, resp.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1085
- DOI:
- 10.4238/vol10-2gmr1085
Effects of curcumin on hippocampal expression of NgR and axonal regeneration in A�²-induced cognitive disorder rats
Authors: H.L. Yin, Y.L. Wang, J.F. Li, B. Han, X.X. Zhang, Y.T. Wang and S. Geng
Curcumin has been widely used for the prevention and treatment of Alzheimer’s disease (AD), but its mechanism is still not clear. Inhibitory factors of axonal regeneration have been shown to cause a series of pathophysiological changes in the early period of AD. In this study, the co-receptor (Nogo receptor; NgR) of thre.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.24.8
- DOI:
- 10.4238/2014.March.24.8
Gene expression characteristics of growth-inhibited rice seedlings induced by low-energy N+-beam implantation
Authors: H. Ya, Q. Chen, W. Wang and Y. Cheng
Using the RNA sequencing, transcriptomes of growth-inhibited rice seedlings induced by low-energy N+-beam implantation were analyzed. The results showed that rice genes related to binding, electron carrier activity, transcription factor, auxin signal transduction, photosynthesis, and oxidoreductase activity were involved in th.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.15.9
- DOI:
- 10.4238/2014.August.15.9