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Chagas disease and triatomine biology (Heteroptera, Triatominae), with emphasis on aspects of spermatogenesis
Authors: R. Silistino-Souza
A century after the discovery of Chagas disease, it is still one of the most important parasitic diseases affecting humans. The subfamily Triatominae is important in medical health, because these insects are vectors of Trypanosoma cruzi, the etiologic agent of Chagas disease. These insects are also of important cytological rel.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3ta039
- DOI:
- 10.4238/vol10-3ta039
Soybeans as bioreactors for biopharmaceuticals and industrial proteins
Authors: G.R. Vianna, N.B. Cunha, A.M. Murad and E.L. Rech
Plants present various advantages for the production of biomolecules, including low risk of contamination with prions, viruses and other pathogens, scalability, low production costs, and available agronomical systems. Plants are also versatile vehicles for the production of recombinant molecules because they allow protein expr.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1476
- DOI:
- 10.4238/vol10-3gmr1476
Genetic analysis of NaCl tolerance in tomato
Authors: A. Saeed, M.Q. Shahid, S.A. Anjum, A.A. Khan, A. Shakeel, M.F. Saleem and N. Saeed
We attempted to find the suitable parents for the development of tomato hybrids for high salt soils by exploiting combining ability, gene action and heterosis. Six salt-tolerant and three salt-intolerant genotypes, along with their 18 F1 crosses, were evaluated at seedling stage under 10 and 15 dS/m (NaCl) salinity stress, com.. Read More»
- Genet. Mol. Res. 10(3):
Association of T869C gene polymorphism of transforming growth factor-�²1 with low protein levels and anthropometric indices in osteopenia/osteoporosis postmenopausal Thai women
Authors: D. Utennam, A. Tungtrongchitr, B. Phonrat, R. Tungtrongchitr and S. Preutthipan
Osteoporosis is the most common metabolic bone disease; it is an important health problem among postmenopausal women. We evaluated the association of three polymorphisms, T869C, C-509T and G915C, of the TGF-β1 gene with bone mineral density (BMD) serum TGF-β1 levels in 278 postmenopausal female osteopenia/osteoporosi.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.13.2
- DOI:
- http://dx.doi.org/10.4238/2012.January.13.2
Involvement of the mitfa gene in the development of pigment cell in Japanese ornamental (Koi) carp (Cyprinus carpio L.)
Authors: J.H. Liu, S. Wen, C. Luo, Y.Q. Zhang, M. Tao, D.W. Wang,S.M. Deng and Y.M. Xiao
A colored phenotype is an important feature of ornamental fish. In mammals, microphthalmia-associated transcription factor (MITF) was found to regulate the development of melanocytes. In this study, the mitfa cDNA was first cloned from the Japanese ornamental (Koi) carp (Cyprinus carpio L.), an important ornamental freshwater fish. The full-length cDNA of.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.31.7
- DOI:
- http://dx.doi.org/10.4238/2015.March.31.7
Clinical outcome in chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation: the experience of the Bone Marrow Transplantation Unit of FUNFARME/BRAZIL using FISH
Authors: C.B. Vendrame-Goloni, A.B. Carvalho-Salles, M.A. Ruiz,O. Ricci J�ºnior, M. Varella-Garcia4 and A.C. Fett-Conte
Investigation of the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in chronic myeloid leukemia patients is essential to predict prognosis and survival. In 20 patients treated at the Bone Marrow Transplantation Unit of São José do Rio Preto (São Paulo, Brazil), we used fluoresce.. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr396
- DOI:
- 10.4238/vol7-2gmr396
Proteomic and bioinformatic analysis of outer membrane proteins of the protobacterium Bartonella henselae (Bartonellaceae)
Authors: D.M. Li, Q.Y. Liu, F. Zhao, Y. Hu, D. Xiao, Y.X. Gu, X.P. Song and J.Z. Zhang
Bartonella henselae, an infectious agent causing cat-scratch disease and vasculoproliferative disorders in humans, is a fastidious facultative intracellular pathogen. The outer membrane proteins of B. henselae are key molecules that play a primary role in host-cell interactions. We isolated B. henselae outer membrane proteins,.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1153
- DOI:
- 10.4238/vol10-3gmr1153
Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population
Authors: J.R. Xu, Y. Yang, X.M. Liu, J.Y. Sun and Y.J. Wang
The T-cell immunoglobulin and mucin domain 1 (TIM-1) is known to be associated with susceptibility to rheumatoid arthritis (RA). We investigated the association of four single-nucleotide polymorphisms (SNPs) in the promoter region of the TIM-1 gene with susceptibility to RA in a Chinese Hui ethnic minority group. Using RFLP or.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.9.7
- DOI:
- http://dx.doi.org/10.4238/2012.January.9.7
No evidence for association between DRD3 and COMT with schizophrenia in a Malay population
Authors: S.F. Tee, P.Y. Tang and H.C. Loh
Molecular components of the dopamine D3 receptor (DRD3) may play an important role in the pathophysiology of schizophrenia. Previous studies have demonstrated an association between DRD3 Ser9Gly and cathechol-o-methyltransferase (COMT, SNP = rs165656) polymorphisms and schizophrenia but the results were inconclusive. We invest.. Read More»
- Genet. Mol. Res. 10(3):
An improved reverse dot hybridization for simple and rapid detection of adefovir dipivoxil-resistant hepatitis B virus
Authors: Y. Hu, W.L. Zhang, S.L. Xie, Y. Zhao, J.L. Hu, X.F. Cai, G.Q. Lai and A.L. Huang
Early detection of adefovir dipivoxil-resistant mutants during long-term treatment of chronic hepatitis B virus (HBV) infection with this drug is of great clinical importance. We developed an improved reverse dot hybridization test for simple and rapid detection of the rtA181V/T and rtN236T mutations associated with adefovir d.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.9.6
- DOI:
- http://dx.doi.org/10.4238/2012.January.9.6