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Effect of everolimus on the expression of Ki-67 and caspase-3 in patients with neuroendocrine tumors
Authors: H.Y. Zhang, X.B. Cheng, Y. Li, L.D. Jin, H.P. Yin
Tumors, especially neuroendocrine tumors (NETs), can cause adverse effects on human health. The expression and significance of Ki-67 and caspase-3 in NET remain to be further explored. Everolimus is an important drug used for the treatment of NETs. In this study, we aimed to investigate whether everolimus exerts anti-tumor eff.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019486
- DOI:
- 10.4238/gmr16019486
Effect of generations and environments in the analysis of a partial diallel to improve bean earliness
Authors: N.M. Vale, L.D. Barili, M.H. Souza, L.M.M. Moura, J.E.S. Carneiro, P.C. Carneiro and F.L. Silva
The objective of this study was to select genitors based on F1 and F2 generations, evaluated in different environments, to obtain segregating populations for the identification of strains showing improved earliness, yield, and carioca-type grains. Nine bean strains were crossed in a partial diallel scheme (4 x 5), in which group 1 included 4 strains with .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.9
- DOI:
- 10.4238/2015.July.27.9
Gene expression of coffee seed oxidation and germination processes during drying
Authors: G.C. Santos, E.V.R. von Pinho and S.D.V.F. Rosa
Coffee (Coffea arabica L.) seeds are sensitive to desiccation and oxidative stress during drying processes. We investigated the effect of drying and moisture levels on germination-related gene expressions associated with enzymatic systems that prevent oxidative stress in coffee seeds. Coffee seeds collected at physiological maturity were subjected to slow.. Read More»
- Genet. Mol. Res. 12(4):
- 2013
- DOI:
- 10.4238/2013
Association between eNOS polymorphisms and risk of coronary artery disease in a Korean population: a meta-analysis
Authors: J.H. Sung, B.E. Lee2, J.O. Kim2, Y.J. Jeon2, S.H. Kim1, S.W. Lim, J.Y. Moon, D.H. Cha, O.J. Kim, I.J. Kim and N.K. Kim
Coronary artery disease (CAD), a multifactorial disease, is a common cause of mortality in humans. Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (-786T>C, 4a4b, and 894G>T) have been previously associated with increased CAD risk. However, the sample size of this previous study was too small and limited to comprehensively define .. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Effects of ginsenoside Rg1 on glucose metabolism and liver injury in streptozotocin-induced type 2 diabetic rats
Authors: W. Tian, L. Chen, L. Zhang, B. Wang, X.B. Li, K.R. Fan, C.H. Ai, X. Xia, S.D. Li, Y. Li
Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by high blood glucose levels. T2-DM patients suffer from many complications, such as diabetic fatty liver and diabetic nephropathy. The liver, the pivotal organ involved in both glucose and lipid metabolism, is primarily damaged in T2-DM patients, e.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019463
- DOI:
- 10.4238/gmr16019463
Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases
Authors: Z.-Z. Liang, J. Li, S.-G. Huang
The objective of this study was to observe the distribution of macrophages (MPs) expressing transforming growth factor beta-1 (TGF-β1) in tissue samples from patients with different human chronic periapical diseases. In this study, samples were collected from 75 volunteers, who were divided into three groups according to .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019329
- DOI:
- 10.4238/gmr16019329
Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes
Authors: Y.L. Chen, D. Pei, Y.J. Hung, C.H. Lee, F.C. Hsiao, C.Z. Wu,J.D. Lin, C.H. Hsu, J.B. Chang and C.H. Hsieh
Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia. Subjects with type 2 diabetes (T2D) exhibit features of MetS. The etiology of MetS is complex, involving both environmental and genetic factors. In this study, we examined the role of specific candidate genetic variants on the severity of MetS in T2D subjec.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.10
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.10
Evaluation of progenies from the fifth reciprocal recurrent selection cycle in maize
Authors: N.B. Alves, J.M.V. P�¡dua, K.O.G. Dias, R.P. Diniz, M.L. Guedes, G.A. Cardoso and J.C. Souza
The objective of this study was to evaluate the performance of 119 full sib progenies of the fifth cycle of reciprocal recurrent selection (RRS) derived from of Universidade Federal de Lavras maize breeding program. The experiment was carried out in an 11 x 11 triple lattice design at two locations (Lavras, Lambari). The plots consisted of two rows of 3 m.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.11
- DOI:
- 10.4238/2015.July.27.11
Disease indicators for sepsis and analysis of sepsis treatment in children using the continuous blood purification technique
Authors: J.P. Liu, X.W. Wang and L.P. Qie
We analyzed disease severity, inflammation markers, and dynamic changes in cartilage glycoprotein 39 (YKL-40) and Creactive protein (CRP) levels in children with sepsis before and after treatment with continuous blood purification (CBP). Study participants were 30 children with severe sepsis who were cured from the disease (experimental group) in the Chil.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.21
- DOI:
- 10.4238/2015.May.25.21
Leaf transcriptome analysis and development of SSR markers in water chestnut (Eleocharis dulcis)
Authors: H.B. Liu, Y.N. You, Z.X. Zhu, X.F. Zheng, J.B. Huang, Z.L. Hu and Y. Diao
Water chestnut (Eleocharis dulcis) is an important aquatic crop in China; however, transcriptomic and genomic data in public databases are limited. To identify genes and development molecular markers, high-throughput transcriptome sequencing was applied to generate transcript sequences from water chestnut leaf. More than 24 million reads were obtained, tr.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.20
- DOI:
- 10.4238/2015.July.27.20