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A contact map matching approach to protein structure similarity analysis
Authors: Raquel C. de Melo, Carlos Eduardo R. Lopes, Fernando A. Fernandes Jr., Carlos Henrique da Silveira, Marcelo M. Santoro, Rodrigo L. Carceroni, Wagner Meira Jr.and Arnaldo de A. Ara�ºjo
We modeled the problem of identifying how close two proteins are structurally by measuring the dissimilarity of their contact maps. These contact maps are colored images, in which the chromatic information encodes the chemical nature of the contacts. We studied two conceptually distinct image-processing algorithms to measure t.. Read More»
- Genet. Mol. Res. 5(2):
Comparative analyses of the structure of the 1,3-�²-glucan synthase gene in Paracoccidioides brasiliensis isolates
Authors: H.T.S. Okamoto, C.M.A. Soares and M. Pereira
The evolutionary origin and significance of spliceosomal introns have been the subject of many investigations. Two theories, “introns- early” theory and “introns-late” theory, have been proposed to explain the evolution of introns in eukaryotic genes. Intron position is generally conserved in paralogue .. Read More»
- Genet. Mol. Res. 5(2):
Association between interleukin-17A polymorphism and coronary artery disease susceptibility in the Chinese Han population
Authors: G.B. Su, X.L. Guo, X.C. Liu, Q.T. Cui and C.Y. Zhou
Coronary artery disease (CAD) is a major global health problem. In China, the incidence of CAD and the rate of mortality arising from it have increased every year. Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by activated T cells, and it may be involved in the development of CAD. Genetic polymorphisms in functional regions of the IL17A .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038235
- DOI:
- 10.4238/gmr.15038235
Molecular analysis of an idic(Y)(qter� p11.32::p11.32�qter) chromosome from a female patient with a complex karyotype
Authors: R. Fernandez and E. Pasaro
A female patient with a structurally abnormal idic(Y) (p11.32) chromosome was studied using fluorescence in situ hybridization and PCR to define the precise position of the breakpoint. The patient had a complex mosaic karyotype with eight cell lines and at least two morphologically distinct derivatives from the Y chromosome. T.. Read More»
- Genet. Mol. Res. 5(2):
Serum microRNA-135a downregulation as a prognostic marker of non-small cell lung cancer
Authors: Y.K. Zhang, B. Sun and G. Sui
Abnormal expression of microRNA-135a (miR-135a) is closely associated with oncogenesis. However, the relationship between serum miR-135a levels and the clinical parameters and prognosis of non-small cell lung cancer (NSCLC) remain unclear. The study aimed to investigate the clinical significance of serum miR-135a expression in patients with NSCLC. miR-135.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038252
- DOI:
- 10.4238/gmr.15038252
PDB-Metrics: a Web tool for exploring the PDB contents
Authors: Renato Fileto, Paula R. Kuser, Michel E.B. Yamagishi, Andr�© A. Ribeiro, Thiago G. Quinalia, Eduardo H. Franco, Adauto L. Mancini, Roberto H. Higa, Stanley R.M. Oliveira, Edgard H. Santos, Fabio D. Vieira, Ivan Mazoni, Sergio A.B. Cruz and Goran Neshich
PDB-Metrics (http://sms.cbi.cnptia.embrapa.br/SMS/ pdb_metrics/index.html) is a component of the Diamond STING suite of programs for the analysis of protein sequence, structure and function. It summarizes the characteristics of the collection of protein structure descriptions deposited in the Protein Data Bank (PDB) and provid.. Read More»
- Genet. Mol. Res. 5(2):
Management of clinically negative nodes (N0) in supraglottic laryngeal carcinoma: A systematic review
Authors: Y.H. Liu and Z.W. Du
The purpose of this study was to evaluate the treatment of clinically negative cervical lymph nodes in supraglottic carcinoma by a meta-analysis. The search words were “supraglottic carcinoma”, “cervical lymph nodes negative/cN0”, “radical neck dissection”, and “radiotherapy”. Th.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048179
- DOI:
- 10.4238/gmr15048179
Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer
Authors: Alessandra D. Clarizia, Luciana Bastos-Rodrigues, HeloÃ?Âsa B. Pena, Charles Anacleto, Benedito Rossi, Fernando A. Soares, Ademar Lopes, JosÃ?© ClÃ?¡udio C. Rocha, OtÃ?¡via Caballero, Anamaria Camargo, Andrew J.G. Simpson and SÃ?©rgio D.J. Pena
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with the expression of a thermolabile enzyme with decreased activity that influences the pool of methyl-donor molecules. Several studies have reported an association between C677T polymorphism and susceptibility to colorectal cancer (CRC). Conside.. Read More»
- Genet. Mol. Res. 5(2):
Rehmannia glutinosa oligosaccharide induces differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells
Authors: X.H. Wang, H.W. Du, X.H. Guo, S.W. Wang, R.B. Zhou, Y. Li, Z.B. Li, Y.S. Zhao and Q.L. Zhu
The aim of this study was to observe the effect of Rehmannia glutinosa oligosaccharide (RGO) on differentiation of bone marrow mesenchymal stem cells (MSCs) into cardiomyocyte-like cells . Rat MSCs were isolated, treated, and grouped as follows: RGO treatment group, 5-azacytidine (5-aza) treatment group, RGO + 5-aza treatment .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047795
- DOI:
- 10.4238/gmr15047795
Biological, serological and molecular typing of potato virus Y (PVY) isolates from Tunisia
Authors: M. Tayahi, C. Gharsallah, N. Khamassy, H. Fakhfakh and F. Djilani-Khouadja
In Tunisia, potato virus Y (PVY) currently presents a significant threat to potato production, reducing tuber yield and quality. Three hundred and eighty-five potato samples (six different cultivars) collected in autumn 2007 from nine regions in Tunisia were tested for PVY infection by DAS-ELISA. The virus was detected in all .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15045165
- DOI:
- 10.4238/gmr15045165