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Genuine Bayesian multiallelic significance test for the Hardy-Weinberg equilibrium law
Authors: C.A.B. Pereira, F. Nakano, J.M. Stern and M.R. Whittle
Statistical tests that detect and measure deviation from the Hardy-Weinberg equilibrium (HWE) have been devised but are limited when testing for deviation at multiallelic DNA loci is attempted. Here we present the full Bayesian significance test (FBST) for the HWE. This test depends neither on asymptotic results nor on the num.. Read More»
- Genet. Mol. Res. 5(4):
Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus
Authors: Q. Li, Z.R. Qiao, D.B. Liu, J.T. Zeng, J. Zhang, Y. Bo, H.Y. Zu, Q. Hu, X. Wu and S.S. Dong
In this study, we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid decarboxylase 2 (GAD2) 5'-untranslated region and the susceptibility to type 2 diabetes in the Han population. The distributions of patients with SNPs in the GAD2 5'-untran.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.10
Clinical observation of umbilical cord mesenchymal stem cell treatment of severe systolic heart failure
Authors: X.F. Zhao, Y. Xu, Z.Y. Zhu, C.Y. Gao and Y.N. Shi
The aim of this study was to evaluate the effectiveness of umbilical cord mesenchymal stem cells (MSCs) in the treatment of chronic systolic heart failure. Fifty-nine hospitalized patients with heart failure were randomly divided into a treatment group (30 patients) and a control group (29 patients). The treatment group received treatment with medication .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.11
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.11
Genetic correlation between heifer pregnancy and scrotal circumference measured at 15 and 18 months of age in Nellore cattle
Authors: J.P. Eler, J.B.S. Ferraz, J.C.C. Balieiro, E.C. Mattos and G.B. Mour?£o
Data of pregnancy diagnosis from 24,945 Nellore heifers, raised under tropical conditions in Brazil and exposed to breeding at about 14 months of age, were analyzed simultaneously with 13,742 (analysis 1), 36,091 (analysis 2), 8,405 (analysis 3), and 8,405 (analysis 4) scrotal circumference (SC) records of contemporary young b.. Read More»
- Genet. Mol. Res. 5(4):
Genetic variations of ISL1 associated with human congenital heart disease in Chinese Han people.
Authors: Z.L. Luo, H. Sun, Z.Q. Yang, Y.H. Ma, Y. Gu, Y.Q. He, D. Wei4, L.B. Xia, B.H. Yang and T. Guo
Congenital heart disease (CHD) is the most common birth abnormality, but the etiology of CHD is unknown. ISL1 may play a fundamental role in cardiac morphogenesis, and mutations of this gene could cause CHD. To evaluate whether genetic variations of ISL1 are associated with CHD in Chinese Han people, polymerase chain reaction .. Read More»
- Genet. Mol. Res. 13(1):
Recognition of ?±-helix transmembrane domains with an amphipathy scale generated by molecular dynamics using only the primary sequence of proteins
Authors: Mazze FM, Fuzo CA, Ciancaglini P and Degreve L
We recently developed an amphipathy scale, elaborated from molecular dynamics data that can be used for the identification of hydrophobic or hydrophilic regions in proteins. This amphipathy scale reflects side chain/water molecule interaction energies. We have now used this amphipathy scale to find candidates for transmembrane.. Read More»
- Genet. Mol. Res. 6(2):
Complete mitochondrial genome of a natural triploid crucian carp mutant, Carassius auratus var. pingxiangnensis, and phylogenetic analysis of different ploidies in crucian carp
Authors: J.Q. Sheng, J.H. Wang, S.H. He, L.G. Zeng, K. Peng and Y.J. Hong
Carassius auratus var. pingxiangnensis is a natural triploid crucian carp mutant. In order to understand its placement and genetic background at the gene level, the characteristics of mitochondrial DNA sequences and phylogenetic relationship were examined. The results showed that the mitochondrial DNA is a ci.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.1.3
- DOI:
- 10.4238/2014.August.1.3
Phylogeography of Brachyplatystoma rousseauxii (Siluriformes - Pimelodidae) in the Amazon Basin offers preliminary evidence for the first case of â??homingâ? for an Amazonian migratory catfish
Authors: J.S. Batista and J.A. Alves-Gomes
The large pimelodid, Brachyplatystoma rousseauxii, is one of the two most important catfish species for the fisheries in the Amazon. It is captured by commercial and artisanal fishing fleets in at least five Amazonian countries, at fishing grounds more than 5000 km apart. Current evidence suggests a complex life cycle that inc.. Read More»
- Genet. Mol. Res. 5(4):
Purification of the insecticidal Cry2Ad protein from a Bt-isolated BRC-HZP10 strain and its toxin assay to the diamondback moth, Plutella xylostella (L.)
Authors: J.Y. Liao, Y.Q. Gao, Q.Y. Wu, Y.C. Zhu and M.S. You
The present study aims to characterize the Cry2Ad toxin protein isolated from a Bacillus thuringiensis strain, BRC-HZP10, which have a potential insecticidal activity against larvae of the diamondback moth, Plutella xylostella (L.). The crude Bt toxin proteins were isolated and purified by cation exchange chromatography, then equilibrated with 0.2 M NaOH .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.11
- DOI:
- 10.4238/2015.July.13.11
Minimization of transcriptional temporal noise and scale invariance in the yeast genome
Authors: Ferreira RC, Bosco F, Paiva PB and Briones MRS
The analysis of transcriptional temporal noise could be an interesting means to study gene expression dynamics and stochasticity in eukaryotes. To study the statistical distributions of temporal noise in the eukaryotic model system Saccharomyces cerevisiae, we analyzed microarray data corresponding to one cell cycle for 6200 g.. Read More»
- Genet. Mol. Res. 6(2):