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General metabolism of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis
Authors: FabrÃ?Âcio B.M. Arraes, Bruno Benoliel, Rafael T. Burtet, PatrÃ?Âcia L.N. Costa, Alexandro S. Galdino, Luanne H.A. Lima, Camila Marinho-Silva, Luciana Oliveira-Pereira, Pollyanna Pfrimer, Luciano ProcÃ?³pio-Silva, Viviane Castelo-Branco Reis and Maria Sueli S. Felipe
Annotation of the transcriptome of the dimorphic fungus Paracoccidioides brasiliensis has set the grounds for a global understanding of its metabolism in both mycelium and yeast forms. This fungus is able to use the main carbohydrate sources, including starch, and it can store reduced carbons in the form of glycogen and trehal.. Read More»
- Genet. Mol. Res. 4(2):
Molecular cloning, characterization, and expression analysis of a Broad-Complex homolog during development in the oriental river prawn Macrobrachium nipponense
Authors: S.F. Jiang, Y.P. Zhang, S.M. Sun, Y.S. Gong, Y.W. Xiong, H. Qiao, W.Y. Zhang, S.B. Jin and H.T. Fu
Broad-Complex (BR-C) is an early ecdysone-responsive gene encoding a family of zinc-finger transcription factors. In this study, we isolated the full-length cDNA of a BR-C homolog from the testes of the oriental river prawn (Macrobrachium nipponense), according to established expressed sequence tag information, using the rapid amplification of cDNA ends t.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.4
- DOI:
- 10.4238/2015.May.18.4
Bioinformatics of the Paracoccidioides brasiliensis EST Project
Authors: Marcelo M. BrÃ?Âgido, Maria EmÃ?Âlia M.T. Walter, Adilton G. Oliveira, Marcus K. Inoue, Daniel S. Anjos, Edans F.O. Sandes, JoÃ?£o J. Gondim, Maria JosÃ?© de A. Carvalho, Nalvo F. Almeida Jr. and Maria Sueli Soares Felipe
Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, an endemic mycosis of Latin America. This fungus presents a dimorphic character; it grows as a mycelium at room temperature, but it is isolated as yeast from infected individuals. It is believed that the transition from mycelium to yeast is impor.. Read More»
- Genet. Mol. Res. 4(2):
Pharmacology of a traditional Chinese herb, Shuangren-Anshen capsule, in a hemorrhage mouse model by using an orthogonal array design
Authors: X.X. Liu, A. Agudamu, X. Zhang, Y. Wei, X. Song and Y.L. Li
Shuangren-Anshen capsule (SAC) is a traditional Chinese herb that was improved in our laboratory. An orthogonal experiment [L9(3)4] was used to optimize the extraction conditions. In vivo, a hemorrhage mouse model was established and the hemoglobin contents of normal control, model control, and treated mice were measured. Additionally, the sedative and hy.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038806
- DOI:
- 10.4238/gmr.15038806
Effects of changes in serum endostatin and fibroblast growth factor 19 on the chemotherapeutic sensitivity in acute myeloid leukemia patients
Authors: Y.Z. Su, C.B. Wang, Y. Zhou and N.T. Sun
The present study aimed to explore the changes in serum endostatin and fibroblast growth factor 19 (FGF-19) in acute myeloid leukemia patients, and to determine their effects on chemotherapeutic sensitivity. Sixty acute myeloid leukemia patients and 30 healthy controls were included in the study. Patient serum endostatin and FGF-19 levels were measured on.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.8
- DOI:
- 10.4238/2015.May.18.8
Paracoccidioides brasiliensis - Special Session
Authors: Maria Sueli Soares Felipe
Paracoccidioidomycosis (PCM) is the most important systemic mycosis in Brazil, and it is widespread throughout Latin America. An estimated 10 million individuals are infected, with about 2% developing the disease. This mycosis has also been reported among patients with AIDS in Latin America. PCM presents several clinical forms.. Read More»
- Genet. Mol. Res. 4(2):
Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression
Authors: L. Meng, Z. Lv, Z.Z. Yu, D. Xu and X. Yan
This study aimed to explore the protective effect of quercetin on acute lung injury (ALI) in rats with sepsis and the related mechanism. Rats were administered different doses of quercetin intraperitoneally, and blood samples and lung tissue were collected at 24 h after treatment. Arterial blood gases, lung water content, protein content, and cell counts .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037265
- DOI:
- 10.4238/gmr.15037265
Effects and mechanisms of Fenofibrate on the secretion of vascular endothelial contraction factors in hypertensive rats
Authors: Y. Zhu, H.-S. Wang, X.-M. Li and C. Qu
This study investigated the effects of the peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, Fenofibrate, on the secretion of vascular endothelial contraction factors in hypertensive rats to elucidate its possible mechanisms. The vascular ring contraction experiment was used to observe whether rat vascul.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.5
- DOI:
- 10.4238/2014.July.24.5
Identification of microsatellite markers in coffee associated with resistance to Meloidogyne exigua
Authors: T.B. Pereira, T.A. Setotaw, D.N. Santos, A.N.G. Mendes, S.M.L. Salgado, G.R. Carvalho and R.M. Rezende
Meloidogyne species are destructive phytonematodes that result in reduced yields of coffee. The classic test for resistance to Meloidogyne exigua in coffee progenies is both expensive and time-consuming. The use of molecular marker techniques can assist the selection process when it is difficult to measure the phenotype, such as in cases of resistance to .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038054
- DOI:
- 10.4238/gmr.15038054
Association of NF-�ºB1 gene polymorphisms with coronary artery disease in a Han Chinese population
Authors: X.L. Guo, X.C. Liu, G.B. Su, C.Y. Zhou and Q.T. Cui
Nuclear factor (NF)-κB is a transcription factor that controls cell proliferation, differentiation, and immunity. Activated NF-κB1 is associated with the pathogenesis of coronary artery disease (CAD) and genetic polymorphisms in NF-κB1 have a plausible role in modulating the risk of CAD. To identify markers that contribute to the genetic.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038072
- DOI:
- 10.4238/gmr.15038072