Polymorphism
Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer
Authors: J.Y. Gu and L. Tu
Here, we performed a case-control study to investigate the role of miR-146a, miR-149, and miR-196a2 polymorphisms in the development of gastric cancer using a hospital-based case-control design. A total of 186 gastric cancer patients and 186 control subjects were enrolled from Ren Ji Hospital between January 2012 and October 2.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027839
- DOI:
- 10.4238/gmr.15027839
Role and diagnostic value of gene variants in assessing the risk of chronic obstructive pulmonary disease
Authors: Z.P. Yan, X. Tong, S.T. Liu, Y. Ma, S.F. Peng, X. Yang and H. Fan
Meta-analyses have revealed many positive associations between gene variants and susceptibility to chronic obstructive pulmonary disease (COPD). However, some of those positive results may be false positives. Therefore, we investigated the genetic polymorphisms associated with COPD risk and determined their diagnostic value. W.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027854
- DOI:
- 10.4238/gmr.15027854
Relationship between genetic polymorphisms in MCP-1, CCR-2, and non-small-cell lung cancer in the Han nationality of Northern China
Authors: L. Yang,J. Wang,F.-G. Li,M. Han,X.-J. Chang and Z.-T. Wang
Lung cancer is a common malignant tumor worldwide and is now the leading cause of cancer-related deaths. Monocyte chemoattractant protein 1 (MCP-1) and its receptor chemokine receptor 2 (CCR-2) are important chemokines. We examined the polymorphisms of 338 unrelated patients with non-small cell lung carcinoma (NSCLC) and 200 unrelated healthy controls of .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.2
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.2
T174M polymorphism in the angiotensinogen gene and risk of myocardial infarction: ameta-analysis
Authors: P.Y. Hu,Y.W. Wang,X.H. Pang and H.W. Wang
Numerous studies have evaluated the association between the T174M polymorphism in the angiotensinogen (AGT) gene and myocardial infarction (MI) risk. However, the specific association remains controversial because of small sample sizes and varied study designs among different studies. We performed a meta-analysis to assess this correlation. A comprehensiv.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.5
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.5
Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis
Authors: J.Z. Peng, L. Xue, D.G. Liu and Y.H. Lin
Although many epidemiologic studies have investigated the p53 codon 72 polymorphism and its association with esophageal cancer (EC) in China, definite conclusions could not be drawn. To clarify the effects of p53 codon 72 polymorphism on the risk of EC, we performed a meta-analysis on the Chinese population. A total of 13 studies including 3308 patients a.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.11
- DOI:
- 10.4238/2015.August.7.11
Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: a meta-analysis
Authors: J.A. Zhang, J.R. Li and Y.J. Qiao
The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using metaâÃ?Â?Ã?Â?analysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CI.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.26
- DOI:
- 10.4238/2015.August.7.26
Association between a microRNA-214 binding site polymorphism in the methylenetetrahydrofolate reductase gene and esophageal squamous cell carcinoma
Authors: G.R. Shen, W.Z. Li, Y.C. Liu, X.P. Li and H.Y. Yuan
MicroRNAs (miRNAs) are key regulators of gene expression and play an important role in the development and progression of various diseases including esophageal squamous cell carcinoma (ESCC). In this study, we determined whether a polymorphism at the miR-214 binding site in the 3'-untranslated region (3'-UTR) of the methylenet.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028158
- DOI:
- 10.4238/gmr.15028158
Association between rs155971 in the PCSK1 gene and the lipid profile of obese Thai children: a family-based study
Authors: S. Kulanuwat, J. Santiprabhob, B. Phonrat, C. Limwongse, A. Tungtrongchitr, N. Chongviriyaphan and R. Tungtrongchitr
Genetic variants of the POMC and PCSK1 genes cause severe obesity among patients in the early stages of childhood. This family-based study analyzed the links between single nucleotide polymorphisms (SNPs) in either the POMC or PCSK1 genes and obesity, as well as obesity-related traits among obese Thai children and their families. The variants rs1042571 an.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.23
- DOI:
- 10.4238/2015.August.7.23
Polymorphisms in the bovine CIDEC gene are associated with body measurement traits and meat quality traits in Qinchuan cattle
Authors: C.G. Mei, L.S. Gui, C.Z. Fu, H.C. Wang, J.L. Wang, G. Cheng and L.S. Zan
Previous studies have shown that the cell death-inducing DFF45-like effector-C (CIDEC) gene is involved in lipid storage and energy metabolism, suggesting that it is a potential candidate gene that affects body measurement traits (BMTs) and meat quality traits (MQTs). The aim of this study was to identify polymorphisms of the bovine CIDEC gene and analyze.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.10
- DOI:
- 10.4238/2015.August.7.10
Polymorphisms in the SIRT5 gene and their association with body measurement and ultrasound traits in Qinchuan cattle
Authors: L.S. Gui,H.C. Wang,G.Y. Liu and L.S. Zan
Silent information regulator 5 (SIRT5), a member of the Sirtuin family class III nicotinamide adenine dinucleotide-dependent protein deacetylases, plays an important role in metabolic and aging processes in mammals. We identified 4 single-nucleotide polymorphisms (SNPs) (G22010A, G22052A, G22119T, and G22245C) in the 3' untranslated regions of the SIRT5 g.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.13
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.13