Polymorphism
Identification of sequence-related amplified polymorphism markers linked to the red leaf trait in ornamental kale (Brassica oleracea L. var. acephala)
Authors: Y.S. Wang, Z.Y. Liu, Y.F. Li, Y. Zhang, X.F. Yang and H. Feng
Artistic diversiform leaf color is an important agronomic trait that affects the market value of ornamental kale. In the present study, genetic analysis showed that a single-dominant gene, Re (red leaf), determines the red leaf trait in ornamental kale. An F2 population consisting of 500 individuals from the cross of a red leaf double-haploid line â.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.3
- DOI:
- 10.4238/2013.April.2.3
Association of cytokine gene polymorphisms with susceptibility to invasive candidiasis
Authors: R.T. Sun, W.J. Tian, X.W. Xing, S.H. Gao and S.B. Wang
The aim of this study was to investigate the role of cytokine genes in the susceptibility to Candida infection. A total of 275 consecutive patients diagnosed with Candida infection were selected between May 2010 and May 2011, along with 305 uninfected controls. Genotyping of the IL-1β gene polymorphisms (IL1β) rs1143634, IL1β rs16944, IL8 r.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.29
- DOI:
- 10.4238/2015.June.18.29
Effect of two single nucleotide polymorphisms on milk yield and composition
Authors: J.C. Rinc�³n, A. L�³pez-Herrera and J.J. Echeverri
The bovine prolactin (PRL) and bovine growth hormone (bGH) genes exhibit several polymorphisms. Some of them can be detected by molecular techniques using restriction endonucleases, such as RsaI for the PRL gene and MspI for the bGH gene. We examined the relationship between the PRL-RsaI and bGH-MspI polymorphisms and some economically important character.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.15
- DOI:
- 10.4238/2013.April.2.15
Polymorphisms of the myostatin gene (MSTN) and its relationship with growth traits in goat breeds
Authors: Z.J. Zhang, Y.H. Ling, L.J. Wang, Y.F. Hang, X.F. Guo, Y.H. Zhang, J.P. Dingand X.R. Zhang
Mutations in the myostatin (MSTN) gene can inactivate its expression and result in a non-functional protein, which leads to dramatic muscularity and a “double-muscling” phenomenon in many species. Using gene sequencing and polymerase chain reaction-single-strand conformation polymorphism methods, polymorphisms of the MSTN gene were investigate.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.12
- DOI:
- 10.4238/2013.April.2.12
Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies
Authors: Y.Z. Li, L.J. Wang, X. Li, S.L. Li, J.L. Wang, Z.H. Wu, L. Gong and X.D. Zhang
Endometriosis is a chronic gynecological disease defined as the presence of the endometrium outside the uterine cavity. Endometriosis is a multifactorial and polygenic disease in which angiogenesis may be implicated. Angiogenesis is under the control of numerous inducers, including vascular endothelial growth factor (VEGF). Many studies have reported that.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.20
- DOI:
- 10.4238/2013.April.2.20
Sequence analysis of the regulatory region of the TNF-RII gene in Polish Holstein-Friesian cows
Authors: A. Stachura, E. Kaczmarczyk and B. BojarojÃ?Â?-Nosowicz
Tumor necrosis factor receptor type II (TNF-RII) is a surface glycoprotein that can form a complex with TNF-α and participate in the body’s immune response. Functions of TNF-RII are impaired in the pathogenesis of viral diseases. We analyzed sequences in the regulatory region of the TNF-RII gene in cattle. An attempt was also made to identify .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.19
- DOI:
- 10.4238/2013.April.2.19
Association between the rs4753426 polymorphism in MTNR1B with fasting plasma glucose level and pancreatic �²-cell function in gestational diabetes mellitus
Authors: Y. Zhan, C. Li, Q. Gao, J. Chen, S. Yu and S.G. Liu
We investigated the association between rs4753426 single nucleotide polymorphisms in the melatonin receptor 1B (MTNR1B) gene and the risk of developing gestational diabetes mellitus (GDM). A total of 516 gravidas (186 with GDM and 330 non-diabetic controls) were enrolled in the study. Genotype and allele frequencies of rs4753426 in the MTNR1B gene were de.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.1
- DOI:
- 10.4238/2015.August.3.1
Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population
Authors: L.M. Qin, G.M. Qin, X.H. Shi, A.L. Wang and H. Zuo
We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism. When compared with contro.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027632
- DOI:
- 10.4238/gmr.15027632
Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis
Authors: Y. Zhang, Y.F. Yu, J.Z. Wang and H. Jia
This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and scree.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.14
- DOI:
- 10.4238/2015.August.3.14
A single nucleotide polymorphism in the promoter region (rs10877887) of let-7 is associated with hepatocellular carcinoma in a Chinese population
Authors: Z.Y. Sui, J. Li, G.L. Cheng and S.F. Wang
Hepatocellular carcinoma (HCC) is a complex polygenic disease whose development is dependent on many genetic factors. The let-7 family, an important and widely studied microRNA family, has been shown to play an important role in the initiation and progression of HCC. In this study, we examined the possible associations between.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027661
- DOI:
- 10.4238/gmr.15027661