Polymorphism
An A/G polymorphism rs3746444 in miR-499 is associated with increased cancer risk: a meta-analysis
Authors: N. Wang, ZQ Tian, Y. Li, R.M. Zhou and G.Y. Wang
An A/G polymorphism (rs3746444) has been identified in the miR-499 gene that can change the conformation of the secondary gene structure and thereby directly affect binding to target mRNAs and the microRNA (miRNA) maturation process, thus altering protein expression and potentially contributing to cancer susceptibility. Numerous studies investigating the .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.14
- DOI:
- 10.4238/2013.September.23.14
Association of the G403A polymorphism in the RANTES gene with coronary artery disease: a meta-analysis
Authors: K. Cui, X.Y. Ge and H.L. Ma
The G403A polymorphism in the RANTES (regulated on activation normal T cell expressed and secreted) gene has a key role in the expression of RANTES, which has been detected in a range of cells in atherosclerotic plaque. However, the association of this polymorphism with the risk of coronary artery disease (CAD) remains controversial. A meta-analysis was p.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.10
- DOI:
- 10.4238/2013.September.23.10
Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease
Authors: Y.Y. Chen, B.N. Wang and X.P. Yu
The aim of the current study was to explore the correlation between serum homocysteine (HCY) levels and the methylene tetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism and coronary heart disease (CHD). We consecutively enrolled 208 patients with CHD confirmed by CTA or coronary angiography from our hospital. An addit.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017238
- DOI:
- 10.4238/gmr.15017238
Association between survivin gene promoter -31G/C and -644C/T polymorphisms and non-small cell lung cancer
Authors: E. Aynaci, E. Coskunpinar, A. Eren, O. Kum, Y.M. Oltulu, N. Akkaya, A. Turna, I. Yaylim and P. Yildiz
Lung cancer is the most common cancer worldwide. Survivin is one of the first reported inhibitors of apoptosis proteins, which is an important family of proteins that regulate apoptosis. The survivin gene is located on human chromosome 17q25, which is composed of 142 amino acids. A common polymorphism of the survivin gene promoter -31G/C has been shown to.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.9
- DOI:
- 10.4238/2013.February.28.9
Association between IL-1�², IL-8, and IL-10 polymorphisms and risk of acute pancreatitis
Authors: D. Li, J. Li, L. Wang and Q. Zhang
We assessed the possible correlation between genetic polymorphisms in interleukin (IL)-1β, IL-8, and IL-10 and risk of acute pancreatitis. Polymorphisms of IL-1β +3954C/T (rs1143634), IL-1β -511C/T (rs16944), IL-8 -251T/A (rs4073), IL-10 -1082A/G (rs1800896), and IL-10 -819C/T (rs1800871) were assessed by polymerase chain reaction-restricti.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.6
- DOI:
- 10.4238/2015.June.18.6
Association between FTO polymorphism in exon 3 with carcass and meat quality traits in crossbred ducks
Authors: W. Gan, Q. Song, N.N. Zhang, X.P. Xiong, D.M.C. Wang and L. Li
The fat mass and obesity-associated gene (FTO) is an excellent candidate gene that affects energy metabolism. Single nucleotide polymorphisms (SNPs) in FTO are associated with carcass and meat quality traits in pigs, cattle, and rabbits. The aim of this study was to investigate the association between novel SNPs in the FTO coding region and carcass and me.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.14
- DOI:
- 10.4238/2015.June.18.14
Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea
Authors: Y. Zhang, N.-F. Li, S. Abulikemu, D.-L. Zhang, Y.-C. Wang, J.-Q. Kong, G.-L. Nuer, Z.-T. Yan, H.-J. Li, J.-H. Zhang and X.-Y. Zhang
Recent data have indicated that inflammation may have an important correlation with obstructive sleep apnea (OSA). Studies have indicated a relationship between OSA and TNF-α gene polymorphisms. Zinc finger protein 36 (ZFP36) regulates TNF-α mRNAs. However, ZFP36 gene polymorphisms have not been investigated in OSA. Therefore, we conducted the.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.17
- DOI:
- 10.4238/2015.June.18.17
Association between interleukin gene polymorphisms and risk of recurrent oral ulceration
Authors: C. Jing and J.-Q. Zhang
We conducted a case-control study to investigate the association between the functional IL-1β+3954 (C/T), IL-6-174 (G/C), IL-10-1082 (G/A), and IL-10-819C/T genetic polymorphisms and risk of recurrent oral ulceration (ROU) in a Chinese population. Polymorphisms of IL-1β+3954C/T, IL-6-174G/C, IL-10-1082A/G and IL-10-819C/T were assessed by polyme.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.26
- DOI:
- 10.4238/2015.June.18.26
Association between the MTHFR C677T gene polymorphism and essential hypertension in South West Cameroon
Authors: S.M. Ghogomu, N.E. Ngolle, R.N. Mouliom and B.F. Asa
The association of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and essential hypertension has been reported but with controversial results in diverse populations in Asia and Europe, thereby suggesting a dependency on ethnicity. The aim of this study was to investigate the association between the MTHFR C677T polymorphism and ess.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017462
- DOI:
- 10.4238/gmr.15017462
Analysis of DRB3 gene polymorphisms in Jafarabadi, Mediterranean, and Murrah buffaloes from Brazil
Authors: N.B. Stafuzza, L.M. Olivatto, B.C.M. Naressi, H. Tonhati and M.E.J. Amaral-Trusty
The DRB3 gene is an MHC class II gene that has a high degree of polymorphism with more than 100 alleles described in cattle. This variation contributes to differences among individuals in immune responsiveness and disease resistance. In this study, we searched for allelic variants in exon 2 of the DRB3 gene in 80 river buffaloes of three breeds in Brazil .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016368
- DOI:
- 10.4238/gmr.15016368