Polymorphism
WNT10A polymorphism may be a risk factor for non-syndromic hypodontia
Authors: S.J. Zhang and Z.Z. Wu2
This study was designed to determine whether polymorphisms in the gene wingless-type MMTV integration site family, member 10A (WNT10A) are associated with non-syndromic hypodontia (tooth agenesis). A case-control study was performed involving 129 subjects with sporadic non-syndromic hypodontia (cases) and 218 healthy individuals (controls). DNA was obtain.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016033
- DOI:
- 10.4238/gmr.15016033
Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population
Authors: D.H. Ma, Q.Y. Xu, Y. Liu, Q.Q. Zhai and M.H. Guo
In this study, we investigated the association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples by polyme.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027570
- DOI:
- 10.4238/gmr.15027570
Identification of trends in scientific publications related to genetic polymorphisms in gestational diabetes mellitus
Authors: J.S. Gomes, L.B. Minasi, A.D. da Cruz and F.M. Rodrigues
Gestational diabetes is a genetic multifactorial systemic disease that has been extensively studied. Consequently, there is a large volume of scientific literature pertaining to genes associated with gestational diabetes. The aim of this study was to characterize the main trends in scientific publications focusing on the assoc.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027672
- DOI:
- 10.4238/gmr.15027672
Role of IL-10 gene polymorphisms in the development of acute pancreatitis
Authors: B.Z. Jiang, L. Tang, H. Xue and D.P. Liu
Recent studies have suggested that chemokines contribute to the initiation and development of acute pancreatitis. We evaluated the relationship between IL-10 gene polymorphisms (-1082A/G and -819T/C) and development of acute pancreatitis in the Chinese population, in order to provide data for screening high-risk Chinese indivi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027743
- DOI:
- 10.4238/gmr.15027743
Functional polymorphisms of the cyclooxygenase-2 gene and prognosis of hepatocellular carcinoma - a cohort study in Chinese people
Authors: R. Liang, X.X. Yan, Y. Lin, Q. Li, C.L. Yuan, Z.H. Liu and Y.Q. Li
Cyclooxygenase-2 (COX-2) influences carcinogenesis through regulation of angiogenesis, apoptosis, cytokine expression, and immune response suppression. It has been well established that COX-2 is overexpressed in a variety of human cancers, such as hepatocellular carcinoma (HCC). In this study, we aimed to evaluate the associat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028093
- DOI:
- 10.4238/gmr.15028093
Common variant rs7579169 is associated with preeclampsia in Han Chinese women
Authors: L.F. Guo, Z.H. Wang and Y.F. Wang
As a heterogeneous group of disorders in pregnancy, many genetic factors are involved in the development of preeclampsia. The single nucleotide polymorphism (SNP) rs7579169, located on chromosome 2q14.2, has been shown to be associated with pregnancy-induced hypertension in Europeans. In this study, we examined whether the SNP.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028114
- DOI:
- 10.4238/gmr.15028114
Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage
Authors: L. Luo, D.H. Li, S.G. Wei, H.B. Zhang, S.B. Li and J. Zhao
Endothelial nitric oxide synthase (eNOS) is an enzyme that influences placental human chorionic gonadotropin production during gestation. Previous studies have indicated an association between eNOS activity, implantation, and maintenance of pregnancy, but proposed associations between polymorphisms of the eNOS gene and recurrent miscarriage (RM) are contr.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.6
- DOI:
- 10.4238/2013.September.23.6
Development of highly polymorphic EST-SSR markers and segregation in F1 hybrid population of Vitis vinifera L.
Authors: E. Kayesh, Y.Y. Zhang, G.S. Liu, N. Bilkish, X. Sun, X.P. Leng and J.G. Fang
The objectives of this investigation were to develop and validate the expressed sequence tag (EST)-simple sequence repeat (SSR) markers from large EST sequences, and to study the segregation and distribution of SSRs within two grapevine parental lines. In total, 94 F1 lines crossed between “Early Rose” and “Red Globe” were studied... Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.5
- DOI:
- 10.4238/2013.September.23.5
Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population
Authors: B. Yang, J.R. Xu, X.M. Liu, Y. Yang, X.F. Na, M. Li and Y.J. Wang
We investigated a possible association of polymorphism of the eNOS gene and essential hypertension in the Chinese Hui population; polymorphisms of rs2070744 (T>C), rs1799983 (G>T), rs1800780 (A>G), and rs3918181 (A>G) loci of the eNOS gene were examined. We found that the genotypic frequencies at rs1799983 and rs1800780 loci differed significa.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.26.2
- DOI:
- 10.4238/2013.March.26.2
Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population
Authors: L.J. Cui, X.Y. Chang, L.Y. Zhu, G. Feng, T. Zhou, C.X. Zhang, K.Y. Chong and K. Sun
Recently genome-wide association studies on East Asian populations reported an association between diabetes and several single nucleotide polymorphisms (SNPs) in a 40-kb linkage disequilibrium block in intron 15 of KCNQ1. However, the association between KCNQ1 variants and type 2 diabetes mellitus (T2DM) in Chinese Kazakh popu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027503
- DOI:
- 10.4238/gmr.15027503