Polymorphism
Genetic polymorphism at the KIR gene locus: determination of gene, genotype, and haplotype frequencies in the Xinjiang Han population
Authors: G.-Y. Lin, B. Yu, W.-J. Hu, Y.-Z. Zhang, X.-J. Zuo and Y.-B. Wang
The aim of this study was to explore the genetic polymorphism, genotype, and haplotype characteristics of the KIR locus in the Xinjiang Han population in order to establish a foundation for future analysis of the relationship between KIR genes and disease. KIR genes were detected by sequence-specific primer-polymerase chain reaction in 184 randomly select.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.7
- DOI:
- 10.4238/2015.June.9.7
Association analysis of IGF-I gene expression with growth and reproductive traits in Jinghai yellow chickens
Authors: M.A. Abdalhag, T. Li, L. Duan, T. Zhang, G. Zhang, J. Wang and Y. Wang
The insulin-like growth factor, IGF-I, plays an important role in the development of growth and reproductive traits. Single-strand conformation polymorphism analysis was used to detect and analyze polymorphisms and expression profiles of the IGF-I gene and its association with growth and reproductive traits of Jinghai yellow c.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049205
- DOI:
- 10.4238/gmr15049205
Genetic association between ACTN3 polymorphism and risk of non-acute ankle sprain
Authors: B. Qi, J.Q. Liu and G.L. Liu
In this study, we investigated the association between ACTN3 R577X polymorphism and non-acute ankle sprain by measuring the allele frequency and genotype distribution of ACTN3 in a Chinese Han population. We recruited 100 patients with non-acute ankle sprain and 100 healthy controls with no history of ankle injuries. Mass spec.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048962
- DOI:
- 10.4238/gmr15048962
Matrix metalloproteinase gene polymorphisms and susceptibility to systemic sclerosis
Authors: T.F. Rech, S.B.C. Moraes, M. Bredemeier, J. de Paoli, J.C.T. Brenol, R.M. Xavier, J.A.B. Chies and D. Simon
The major pathological hallmark of the systemic sclerosis (SSc) is skin and internal organ fibrosis, which results from normal tissue architecture alterations and extracellular matrix (ECM) protein deposition. ECM components are degraded by matrix metalloproteinases (MMP). Promoter region polymorphisms in MMP genes may influen.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049077
- DOI:
- 10.4238/gmr15049077
Association between an ACAN gene variable number tandem repeat polymorphism and lumbar disc herniation: a case control study
Authors: N.L.L. Casa, A.J. Casa Junior, A.V. Melo, L.S. Teodoro,G.R. Nascimento, A.F. Sousa, T.C. Flausino, D. Brito, R. Bergamini, L.B. Minasi, A.D. da Cruz, T.C. Vieira and M.P. Curado
We investigated the association between an aggrecan gene (ACAN) polymorphism and lumbar disc herniation (LDH). This was a case-control study with quinquennial age and gender groups. The study comprised 119 men and women aged between 20 and 60 from Goiânia (Brazil). Of these, 39 were allocated to the case group (Ca) and 8.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048867
- DOI:
- 10.4238/gmr15048867
Association between CYP19A1, GSTM1, GSTT1, and GSTP1 genetic polymorphisms and the development of endometriosis in a Chinese population
Authors: Y. Tuo, J.Y. He, W.J. Yan and J. Yang
Endometriosis is a common, complicated, and highly heterogeneous endocrine disease. Many genetic factors could affect the development of endometriosis. We performed a case-control study to evaluate the association between polymorphisms in CYP19A1 rs2899470, GSTM1, GSTT1, and GSTP1 rs1695 and the development of endometriosis in.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048837
- DOI:
- 10.4238/gmr15048837
Association between IL18-607C/A and -137G/C polymorphisms and susceptibility to non-small cell lung cancer in a Chinese population
Authors: W.Y. Gan, H.M. Li, Y.G. Zhang, C.M. Li and Y. Wang
Lung cancer is one of the main causes of cancer-related mortality in males and females worldwide. A pleiotropic effect has been observed in the interleukin 18 gene (IL18); its effects include the activation of natural killer cell cytotoxicity and the promotion of the Th1 immune response through the alteration of the expression.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048822
- DOI:
- 10.4238/gmr15048822
Genomic variability of Pantoea ananatis in maize white spot lesions assessed by AFLP markers
Authors: A.M. Miller, J.E.F. Figueiredo, C.L. Chaves, E.A. Ruas, M.I. Balbi-Pe�±a, N.B. Colauto and L.D. Paccola-Meirelles
Measures to control maize white spot (MWS) caused by Pantoea ananatis are preferentially based on resistant cultivars. A lack of knowledge on the genetic variability of pathogens could interfere with the development and utilization of controlling strategies in this pathosystem. The main goals of this study were to investigate .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049452
- DOI:
- 10.4238/gmr15049452
Association of single-nucleotide polymorphisms, rs2235371 and rs2013162, in the IRF6 gene with non-syndromic cleft palate in northeast China
Authors: W. Xu, W.T. Han, Y.P. Lu, W.H. Feng and M. Dai
The aim of this study was to determine the association between two SNPs (rs2235371 and rs2013162) in the interferon regulatory factor 6 (IRF6) gene and non-syndromic cleft palate (NSCP) in northeast China. We genotyped these two SNPs in 104 NSCP cases, as well as in 178 parents and 300 controls. Case-control and case-parent an.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038210
- DOI:
- 10.4238/gmr.15038210
Association between TXNRD1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a prospective study
Authors: G.Y. Ji, Y. Wang, S.Q. Wu, Q.Q. Liu, J.C. Wu, M.M. Zhang, A.J. Sandford and J.Q. He
Anti-tuberculosis drug-induced hepatotoxicity (ATDH) is a serious adverse reaction to anti-tuberculosis (TB) treatment. Thioredoxin reductase 1 (TXNRD1), encoded by the TXNRD1 gene, is an important enzyme involved in oxidant challenge. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells aga.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038296
- DOI:
- 10.4238/gmr.15038296