Polymorphism
Associations between tumor necrosis factor-�± polymorphisms and susceptibility to pulmonary tuberculosis: meta-analysis
Authors: Y.H. Lee and G.G. Song
The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB) in different ethnic populations. MEDLINE and Embase databases and manual searches were employed to identify articles in which TNF-α polymorphisms were determined in patients with .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.8
- DOI:
- 10.4238/2015.July.31.8
Association between polymorphisms in exons 4 and 10 of the BPI gene and immune indices in Sutai pigs
Authors: Z.C. Wu, Y. Liu, Q.H. Zhao, S.P. Zhu, Y.J. Huo, G.Q. Zhu, S.L. Wuand W.B. Bao
The bactericidal/permeability-increasing protein (BPI) gene has been identified as a candidate gene for disease-resistance breeding. We evaluated whether polymorphisms in exons 4 and 10 of the BPI gene are associated with immune indices [interleukin-2 (IL- 2), IL-4, IL-6, interferon-b (IFN-b), IL-10, and IL-12]. In this study, we identified one mutation (.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.2
- DOI:
- 10.4238/2015.June.8.2
Mn-SOD 47 CC genotype in combination with high tea consumption may prevent complications in Tunisian type-2 diabetes
Authors: H. Abaidi, S. Denden, A. Ghazouani, A. Trim�¨che, C. Snoussi, A. Haj Khelil, J. Ben Chibani and M.H. Hamdaoui
Reactive oxygen species metabolizing enzymes may play an important role in the prevention of type-2 diabetes (T2D) complications. We analyzed the association between Cu/Zn-SOD +35 A/C, Mn-SOD T47C, and CAT -21 A/T gene polymorphisms and complications, in combination with tea consumption in Tunisian T2D. A sample of 366 T2D subjects was enrolled in this st.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.9
- DOI:
- 10.4238/2015.July.31.9
Association of TLR2 and TLR4 non-missense single nucleotide polymorphisms with type 2 diabetes risk in a southern Chinese population: a case-control study
Authors: W.H. Huang, L.H. Nie, L.J. Zhang, L.P. Jing, F. Dong, M. Wang, N. Zhang, Y. Liu, B.H. Zhang, C. Chen, H.S. Lin, X.C. Wei, G. Yang and C.X. Jing
Toll-like receptors (TLRs), the triggers of the innate and adaptive immune responses, are involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Several studies have investigated the effects of genetic polymorphisms in TLR4 and TLR2, but they have yielded limited results. We investigated whether non-missense geneticpolymorphisms in the regulator.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.18
- DOI:
- 10.4238/2015.July.31.18
Common polymorphisms of the microRNA genes (miR-146a and miR-196a-2) and gastric cancer risk: an updated meta-analysis
Authors: Z.F. Chen, L.L. Ma and H.B. Xue
The associations between two common polymorphisms in microRNA genes (miR-146a, dbSNP: rs2910164; miR-196a-2, dbSNP: rs11614913) and gastric cancer risk have frequently been examined; however, the results have often been controversial. This meta-analysis was performed to clarify the association between the two polymorphisms and gastric cancer risk. The lit.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.7
- DOI:
- 10.4238/2015.July.31.7
Association analysis between SNPs in the 5'-flanking region of the chicken GRP78 gene, thermotolerance parameters, and tissue mRNA expression
Authors: L.N. Kong, D.X. Zhang, C.L. Ji, X.Q. Zhang and Q.B. Luo
Glucose-regulated protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum and can be induced by different kinds of environmental and physiological stress. Thus far, the role of the GRP78 gene in thermotolerance in chickens has not been investigated. In the present study, we detected sequence variations in the 5êÃ?Â?Ã?Â?-flanking reg.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.9
- DOI:
- 10.4238/2015.June.8.9
Association between TNFSF4 tagSNPs and myocardial infarction in a Chinese Han population
Authors: J. Cheng, J.-M. Cen, M.-Y. Cai, S. Xu, L. Li, Z.-C. Li, X.-L. Yang, C. Chen, X. Liu and X.-D. Xiong
Tumor necrosis factor superfamily member 4 (TNFSF4) plays an important role in atherosclerosis development. However, the biological significance of TNFSF4 variants on myocardial infarction (MI) pathogenesis remains poorly understood. We investigated the influence of 5 TNFSF4 tagging single nucleotide polymorphisms (rs3861950, rs17346501, rs7518045, rs1234.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.11
- DOI:
- 10.4238/2015.June.8.11
BDNF and DARPP-32 genes are not risk factors for schizophrenia in the Malay population
Authors: H.C. Loh, P.Y. Tang, S.F. Tee, T.J. Chow, Y.C. Cheah and S.S.J. Singh
A number of studies have pointed to the association of BDNF (brain-derived neurotrophic factor) and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) with schizophrenia. The purpose of this study was to determine whether these two genes are involved in the pathogenesis of schizophrenia in the Malay population. Two.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.22.2
- DOI:
- 10.4238/2012.March.22.2
Vitamin D receptor FokI gene polymorphism and tuberculosis susceptibility: a meta-analysis
Authors: Y.P. Sun and Q.S. Cai
Numerous studies have evaluated the association between FokI polymorphisms in the vitamin D receptor (VDR) gene and tuberculosis risk. However, the specific association remains controversial. In this study, we performed a meta-analysis to assess the association between the VDR gene FokI polymorphism and tuberculosis. Published studies from the PubMed and .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.1
- DOI:
- 10.4238/2015.June.9.1
Genetic polymorphisms in extracellular superoxide dismutase Leu53Leu, Arg213Gly, and Ala40Thr and susceptibility to type 2 diabetes mellitus
Authors: Y.M. Yang, X.R. Xie and A.L. Jin
The most common type of endocrine disease is type 2 diabetes mellitus (T2DM); genetic factors contribute to the development to T2DM. In this study, we investigated the role of the Leu53Leu, Arg213Gly, and Ala40Thr polymorphisms in extracellular superoxide dismutase (EC-SOD) gene in the development of T2DM in a Chinese populati.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048418
- DOI:
- 10.4238/gmr15048418