Polymorphism
RT-qPCR assay on the vitamin D receptor gene in type 2 diabetes and hypertension patients in Turkey
Authors: H.C. Vural1 and E. Maltas
RT-qPCR was used to analyze the vitamin D receptor (VDR) gene TaqI polymorphism in 100 Turkish patients with type 2 diabetes mellitus (T2DM) and hypertension compared with 100 healthy subjects, to determine whether VDR could be considered as one of the susceptibility genes for T2DM and hypertension. Genotyping was done with PC.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.14.1
- DOI:
- 10.4238/2012.March.14.1
Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis
Authors: M. Xiao, T. Wang, T. Zhu and F. Wen
Vitamin D-binding protein (DBP), a highly polymorphic serum protein, encoded by GC gene, is important in the development of chronic obstructive pulmonary disease (COPD). This meta-analysis was performed to assess the association between GC polymorphisms (1F, 1S, and 2 alleles) and COPD susceptibility. Published case-control studies were retrieved from the.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.1
Fibroblast growth factor receptor 4 Gly388Arg polymorphism associated with severity of gallstone disease in a Chinese population
Authors: Q. Chen, W.J. Li, Y.Y. Wan, C.D. Yu and W.G. Li
The etiology of gallstone disease is multifactorial; supersaturation of bile with cholesterol is a primary cause for gallstone formation. In previous studies, we found that fibroblast growth factor receptor 4 (FGFR4) plays an important role in maintaining bile acid homeostasis by regulating the expression of cholesterol 7&alph.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.8.3
- DOI:
- 10.4238/2012.March.8.3
Role of TGFB1 polymorphism in the development of metastatic brain tumors in non-small cell lung cancer patients
Authors: H.B. Wang, W.G. Song, H.Q. Liu, F. Fang and Y. Xiao
We conducted a case-control study to investigate the role of 3 single-nucleotide polymorphisms of the gene encoding transforming growth factor-b1 (TGFB1) in the development of metastatic brain tumors in non-small cell lung cancer patients. The polymorphisms in TGFB1 rs4803455, rs1800469, and rs1800470 were evaluated by polymerase chain reaction-restrictio.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.3
Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility
Authors: Z.-Q. Li, X.-P. Hu, , J.-Y. Zhou, X.-D. Xie and J.-M. Zhang
We investigated the role of 7 single nucleotide polymorphisms in the carbonic anhydrase (CA) VI gene (rs2274328, rs17032907, rs11576766, rs2274333, rs10864376, rs3765964, and rs6680186) and the possible association between these polymorphisms and dental caries susceptibility in a Northwestern Chinese population. We collected samples from 164 high caries e.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.16
- DOI:
- 10.4238/2015.June.1.16
IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease
Authors: L. Li, E. Li, L.H. Zhang, L.G. Jian, H.P. Liu and T. Wang
We conducted this case-control study to investigate the genetic role of IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T in the development of coronary artery disease (CAD) in a Chinese population. Polymorphisms IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T were determined by polymerase chain re.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.12
- DOI:
- 10.4238/2015.July.28.12
CYP19 gene polymorphisms and the susceptibility to breast cancer in Xinjiang Uigur women
Authors: L. Yang, X.Y. Wang, Y.T. Li, H.L. Wang, T. Wu, B. Wang, Q. Zhao, D. Jinsihan and L.P. Zhu
In this study, the relationship between CYP19 gene polymorphisms and breast cancer in Xinjiang Uigur women was investigated. A case-control study was designed to compare 112 Uigur breast cancer patients with 139 Uigur healthy controls. Individuals were genotyped for the CYP19 rs10046 polymorphism using polymerase chain reaction restriction fragment length.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.15
- DOI:
- 10.4238/2015.July.28.15
Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis
Authors: X.M. Xie, R. Ke, Y.H. Zhang, G.Z. Wang, Y.T. Zhu, T. Hussian, L. Yang and M.X. Li
Association studies of interleukin-6 (IL-6) -174G>C polymorphism and chronic obstructive pulmonary disease (COPD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. A comprehensive search was performed in the PubMed, Embase, Elsevier, Web of Science databases, Wanfang, and the Chinese National Kn.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.21
- DOI:
- 10.4238/2015.July.28.21
Polymorphisms in different EST-SSR types derived from the Chinese bayberry (Myrica rubra, Myricaceae) transcriptome
Authors: S.Y. Zhang, C. Feng, C.J. Xu, C.Q. Zhu and K.S. Chen
Most plant expressed sequence tag-simple sequence repeats (EST-SSRs) are not polymorphic, and it is important to learn the characteristics of highly polymorphic EST-SSRs. In this study, 357 compound and 5557 non-compound EST-SSRs, identified from the transcriptome of the Chinese bayberry (Myrica rubra ‘Biqi’), were divided into 11 types based .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.21
- DOI:
- 10.4238/2015.June.1.21
Novel SNPs in the growth arrest and DNA damage-inducible protein 45 alpha gene (GADD45A) associated with meat quality traits in Berkshire pigs
Authors: E.S. Cho, K.T. Lee, J.W. Choi, H.J. Jeon, S.W. Lee, Y.M. Cho and T.H. Kim
This study was conducted to evaluate the porcine gene GADD45A (growth arrest and DNA-damage-inducible protein 45 alpha) as a positional candidate controlling quantitative trait loci (QTL) for meat quality traits on chromosome 6 (SSC6). Four exons of the porcine GADD45A gene were defined from cDNA and BAC clone sequences. A total of 4 single nucleotide pol.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.6
- DOI:
- 10.4238/2015.July.31.6